Antibiotic consumption and resistance: Data from Europe and Germany

Meyer, Elisabeth; Gastmeier, Petra; Deja, Maria; Schwab, Frank J.

doi:10.1016/j.ijmm.2013.04.004

Cited by 147 publications

(101 citation statements)

References 25 publications

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“…Another concern is related to the contamination of water and environment with chemical residues. The persistence of antimicrobials in manure and the use of old litter in soil fertilization permits the leakage of drugs into wells and surface water (Phuong Hua et al 2011;Meyer et al 2013;Milic et al 2013;Awad et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Consumption of antibacterial molecules in broiler production in Morocco

Rahmatallah

Rhaffouli

Amine

et al. 2018

Veterinary Medicine & Sci

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Monitoring the use of antibacterial agents in food-producing animals is crucial in order to reduce antimicrobial resistance, selection and dissemination of resistant bacterial strains, and drug residues in the animal food products. The broiler production sector is considered a great consumer of antibacterials and incriminated in the rise of antimicrobial resistance level in zoonotic bacterial pathogens such as Escherichia coli, Salmonella and Campylobacter. Following recommendations from the OIE and WHO, a survey was conducted about the use and consumption of several antibacterial agents in Moroccan broiler flocks. More than 5 million broilers were randomly surveyed at the prescriber level, that is, via the veterinary clinics involved in their health management. The results showed that 93% of the flocks received at least one antibacterial treatment of minimum 3 days duration. Enrofloxacin, colistin and trimethoprim/sulphonamides were the most used antibacterials followed by oxytetracycline, florfenicol and amoxicillin. Oxytetracycline, enrofloxacin and colistin were overdosed in most of the administration, while amoxicillin and the combination of trimethoprim/sulphonamides were under-dosed. The total amount of antibacterial consumed in the survey was 63.48 mg/kg and the Animal Level of Exposure to Antimicrobials (ALEA) was 94.45%. The reasons for this frequent use were related mainly to the poor quality of broiler production management. Chicks and animal feed provided to producers were of variable quality. Management of rearing stock density was often poor and biosecurity inadequate, and broilers were challenged by a high prevalence of infectious diseases.

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Section: Introductionmentioning

confidence: 99%

Consumption of antibacterial molecules in broiler production in Morocco

Rahmatallah

Rhaffouli

Amine

et al. 2018

Veterinary Medicine & Sci

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“…1 The over-and misuse of antibiotics can promote the selection of resistant pathogens and allow their emergence and dissemination. 2 The most efficient mechanism of resistance to beta-lactam antibiotics is enzyme production. 3 The isolation of beta-lactamase-producing strains has rapidly increased due to intra-and inter-species genetic transmission.…”

Section: Introductionmentioning

confidence: 99%

Saliva, supragingival biofilm and root canals can harbor gene associated with resistance to lactamic agents

et al. 2015

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This study aimed to determine the presence of Prevotella strains and genes associated with resistance to lactamics in different oral niches from patients with/without primary endodontic infections. Saliva (S) and supragingival biofilm (SB) were collected from three patient groups: Group I -no endodontic infection (n = 15); Group II -acute endodontic infection (n = 12); and Group III -chronic endodontic infection (n = 15). Root canal (RC) samples were collected from Groups II and III. The presence of P. intermedia, P nigrescens, P. tannerae and cfxA/cfxA2 gene was assessed by PCR. The cfxA/cfxA2 gene was not detected in all environments within the same patient. The cfxA/cfxA2 gene was present in 23.81% of S samples, 28.57% of SB samples, and 7.41% of RC samples. Prevotella species were detected in 53.97%, 47.62% and 34.56% of the S, SB, and RC samples, respectively. P. intermedia had a high frequency in saliva samples from Group 3. Saliva samples from Group 1 had higher detection rates of P. nigrescens than did Groups 2 and 3. Patients without endodontic disease had high frequencies of P. nigrescens in the SB samples. The presence or absence of spontaneous symptoms was not related to the detection rates for resistance genes in the RC samples. Saliva, supragingival biofilm and root canals can harbor resistant bacteria. The presence of symptomatology did not increase the presence of the cfxA/cfxA2 gene in the supragingival biofilm and inside root canals.

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“…Escherichia coli, con un fenotipo sugestivo de BLEE de 16 % por su resistencia a cefalosporinas de tercera generación y a FEP, presentó un comportamiento semejante a lo reportado en las unidades de cuidados intensivos de los países europeos (28); por el contrario, el estudio SENTRY, realizado en cuatro países latinoamericanos, Figura 2. Tendencias en la frecuencia de las bacterias multirresistentes.…”

Section: Resultsunclassified

Evolución de la resistencia antimicrobiana de bacilos Gram negativos en unidades de cuidados intensivos en Colombia

et al. 2013

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el Grupo de Resistencia Bacteriana Nosocomial en Colombia: análisis e interpretación de la epidemiología molecular de los aislamientos. María Virginia Villegas: dirección científica, interpretación de los datos. Todos los autores participaron en la escritura y aprobación final del manuscrito. ARTÍCULO ORIGINAL Biomédica 2014;34(Supl. Conclusiones. Se observó un incremento en la tendencia de los microorganismos hacia la multirresistencia y una amplia distribución de las carbapenemasas. La articulación de la biología molecular con los sistemas de vigilancia permitió integrar el análisis del fenotipo con los mecanismos de resistencia involucrados en las bacterias estudiadas. Este análisis permitirá la elaboración de guías para el uso adecuado de antimicrobianos y contribuirá a la contención de estas bacterias multirresistentes en Colombia.Palabras clave: bacterias Gram negativas, farmacorresistencia bacteriana, vigilancia epidemiológica, Colombia.

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Antibiotic consumption and resistance: Data from Europe and Germany

Cited by 147 publications

References 25 publications

Consumption of antibacterial molecules in broiler production in Morocco

Consumption of antibacterial molecules in broiler production in Morocco

Saliva, supragingival biofilm and root canals can harbor gene associated with resistance to lactamic agents

Evolución de la resistencia antimicrobiana de bacilos Gram negativos en unidades de cuidados intensivos en Colombia

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