Antibiotic-associated adverse drug events at a Japanese academic hospital

Kokado, Ryohei; Hagiya, Hideharu; Koyama, Toshihiro; Matsui, Eiko; Okuno, Hideo; Morii, Daiichi; Hamaguchi, Shigeto; Yoshida, Hisao; Miwa, Yoshiro; Tomono, Kazunori

doi:10.1016/j.jiac.2018.11.002

Cited by 5 publications

(9 citation statements)

References 12 publications

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“…However, some studies have performed analyses to understand the ADEs as well as create procedures and strategies to avoid antibiotics' side effects. 57,58,64,65 Some of these surveys indicate a high rate (19−60%) of ADEs caused by antibiotic therapy among patients in a hospital environment. 57,58,64,65 In these studies, there is a significant variation in ADEs, and this variation is correlated with the antibiotic classes administered in patients, the treatment period, and medical prescribing errors.…”

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

“…57,58,64,65 Some of these surveys indicate a high rate (19−60%) of ADEs caused by antibiotic therapy among patients in a hospital environment. 57,58,64,65 In these studies, there is a significant variation in ADEs, and this variation is correlated with the antibiotic classes administered in patients, the treatment period, and medical prescribing errors. For instance, in a survey conducted by Kokado et al, 64 among the most frequently recorded ADEs were dermatological manifestations (53.4%), followed by liver dysfunction (9.7%) and gastrointestinal disorders (8.9%).…”

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

“…57,58,64,65 In these studies, there is a significant variation in ADEs, and this variation is correlated with the antibiotic classes administered in patients, the treatment period, and medical prescribing errors. For instance, in a survey conducted by Kokado et al, 64 among the most frequently recorded ADEs were dermatological manifestations (53.4%), followed by liver dysfunction (9.7%) and gastrointestinal disorders (8.9%). Concerning the prescribed antibiotics, the β-lactams presented a higher incidence of ADEs, about 51.3%.…”

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

“…However, other antibiotics, including macrolides, sulfonamides, anti-MRSA, and injectable tetracyclines, also have significantly lower ADE rates. 64 A study by Tamma et al 58 reported that the percentages of antibiotic-associated ADEs was around 20%. Furthermore, these authors estimated that every 10 days of additional antibiotic therapy increased the risk of developing ADEs by 3%.…”

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

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Effects of Antibiotic Treatment on Gut Microbiota and How to Overcome Its Negative Impacts on Human Health

et al. 2020

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The need for new antimicrobial therapies is evident, especially to reduce antimicrobial resistance and minimize deleterious effects on gut microbiota. However, although diverse studies discuss the adverse effects of broad-spectrum antibiotics on the microbiome ecology, targeted interventions that could solve this problem have often been overlooked. The impact of antibiotics on gut microbiota homeostasis is alarming, compromising its microbial community and leading to changes in host health. Recent studies have shown that these impacts can be transient or permanent, causing irreversible damage to gut microbiota. The responses to and changes in the gut microbial community arising from antibiotic treatment are related to its duration, the number of doses, antibiotic class, host age, genetic susceptibility, and lifestyle. In contrast, each individual’s native microbiota can also affect the response to treatment as well as respond differently to antibiotic treatment. In this context, the current challenge is to promote the growth of potentially beneficial microorganisms and to reduce the proportion of microorganisms that cause dysbiosis, thus contributing to an improvement in the patient’s health. An essential requirement for the development of novel antibiotics will be personalized medicinal strategies that recognize a patient’s intestinal and biochemical individuality. Thus, this Review will address a new perspective on antimicrobial therapies through pathogen-selective antibiotics that minimize the impacts on human health due to changes in the gut microbiota from the use of antibiotics.

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Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

Section: ■ the Global Problem Of Conventional Antimicrobial Therapiesmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Antibiotic Treatment on Gut Microbiota and How to Overcome Its Negative Impacts on Human Health

et al. 2020

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“…Antibiotics have also been identified as the most frequent contributor to drug‐associated adverse events that have resulted in emergency department visits associated with moderate to severe allergic reactions 4 . Additional antibiotic‐associated adverse drug events include dermatologic symptoms, liver dysfunction, gastrointestinal symptoms, cardiac dysfunction, and drug fever 5 …”

Section: Introductionmentioning

confidence: 99%

Antibiotic prescribing at a periodontal residency practice in Connecticut

McKenna

Ioannidou

Banach

2021

Journal of Periodontology

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Background Antibiotics are important in the treatment of odontogenic infections and the prevention of infection following dental procedures in high‐risk situations. Little is known about antibiotic prescribing in periodontal practice. This study describes prescribing practices by periodontal faculty and residents in an academic setting in order to identify opportunities to optimize prescribing behaviors. Methods This cross‐sectional study analyzed all antibiotic prescriptions from residents or faculty in an academic periodontal clinic from 2014‐2017. Information was manually extracted from the electronic health record. Antibiotic prescriptions were stratified into three indication categories: pre‐procedural prophylaxis, post‐procedural prophylaxis, and treatment. Results Out of 275 prescriptions analyzed, 266 met inclusion criteria. The most frequent antibiotic indication was post‐procedural prophylaxis (n = 130, 48.87%). Amoxicillin was the most frequently prescribed antibiotic across all groups (n = 236, 88.72%), followed by clindamycin (n = 22, 8.27%). Most patients presented in a non‐emergent setting (n = 200, 75.19%), without pain (n = 210, 78.95%), and had restorative/endodontic‐related clinical findings (n = 55, 20.68%). Among the 35 patients receiving antibiotics for infection treatment, 8 (22.86%) underwent a surgical intervention on the date of antibiotic prescription. Of the 130 patients receiving post‐procedural prophylaxis, 121 (93.08%) received surgical interventions on the day of antibiotic prescription. Conclusions Antibiotics are prescribed in various situations in periodontal practice, most frequently as post‐procedural prophylaxis, an indication for which data is limited. There is an urgent need to study the role of post‐procedural prophylactic antibiotics and understand antibiotic prescribing in the management of periodontal disease in order to optimize prescribing practices.

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