Antibiotic as Ligand. Coordinating Behavior of the Cephalexin Towards Zn(II) and Cd(II) Ions

Lozano, Mario Altamirano

doi:10.1016/0162-0134(87)80004-1

Cited by 25 publications

(5 citation statements)

References 6 publications

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“…In some systems (Cu–GA–G, Cu–GA–GG, Cu–GA–GGG, Ni–GA–G, and Cu–FA–G), Δ log K are negative. These negative values may be the result of the high stability of their binary complexes, reduction in the coordination sites of the metal ions, steric hindrance, and electrostatic effect. − For the FA-GG and FA-GGG systems, Δ log K values have a similar tendency as their corresponding binary complexes. It may occur due to the competition between ligands since FA, GG, and GGG show almost similar chelating abilities toward metal ions.…”

Section: Resultsmentioning

confidence: 99%

Cu(II), Co(II), and Ni(II)–Antioxidative Phenolate–Glycine Peptide Systems: An Insight into Its Equilibrium Solution Study

et al. 2012

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The stability of complex formation between divalent transition metal ions, phenolates and glycine peptides was studied at 298.15 K in aqueous solution with an ionic strength of 0.15 mol•dm −3 NaNO 3 . HYPERQUAD 2008, a program based on nonlinear least-squares curve fitting, was used to determine the stability constants of the complexes formed from the pH-potentiometric data. The trends in stability constants of the complexes and the contribution of deprotonated or undeptotonated amide peptide in the stability constant were discussed. From the stability constants that obtained, the representative species distribution diagrams of copper complexes were provided by the HYSS 2009 program. In addition, structures of the formed complexes were predicted by using the Gaussian 09 program. The Gibbs free energies of these complexes were also evaluated in the simulation.

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Section: Resultsmentioning

confidence: 99%

Cu(II), Co(II), and Ni(II)–Antioxidative Phenolate–Glycine Peptide Systems: An Insight into Its Equilibrium Solution Study

et al. 2012

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“…The phenylglycine-type β-lactams have greater complex-forming affinity to cations of p - and d -elements, than cations of s - and f -elements . Although the reports on the metal-complex structures of β-lactams are diverse and even sometimes contradictory, many studies provide evidence of metal coordination via the primary amine group and the amide group on the side chain, just as the metal-dipeptide anion complex. − …”

Section: Introductionmentioning

confidence: 99%

Multiple Roles of Cu(II) in Catalyzing Hydrolysis and Oxidation of β-Lactam Antibiotics

Chen

Sun

Zhang

et al. 2016

Environ. Sci. Technol.

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The widely used β-lactam antibiotics such as penicillins and cephalosporins are known to be susceptible to Cu-catalyzed hydrolysis at their four-membered β-lactam ring. However, this study elucidates that Cu can in fact play multiple roles in promoting the hydrolysis and/or oxidation of β-lactam antibiotics under environmental aquatic conditions (pH 5.0-9.0 and 22 °C), depending on β-lactams' structural characteristics and solution pH. Most significantly, the β-lactam antibiotics that contain a phenylglycine primary amine group on the side chain can undergo direct oxidation by Cu via this functional group. On the other hand, the β-lactam ring of penicillins is susceptible to Cu-catalyzed hydrolysis, followed by oxidation of the hydrolysis product by Cu. In contrast, the β-lactam ring of cephalosporins is susceptible to Cu-catalyzed hydrolysis only. Solution pH influences the Cu-promoted transformation by affecting the β-lactam and Cu complexation through protonation/deprotonation of critical organic functional groups. When Cu acts as an oxidant to promote the transformation of β-lactam antibiotics to yield Cu, the overall role of Cu appears catalytic if the reaction occurs under ambient atmospheric condition, due to quick oxidation of Cu by oxygen to regenerate Cu. Compared to earlier literature that largely assumed only the hydrolytic catalyst role of Cu in promoting degradation of β-lactam antibiotics, the oxidative roles of Cu identified by this study mark important contributions to a more accurate mechanistic understanding.

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“…Phase Ratio: it was found 5ml of aqueous layer and 2ml of organic layer is enough to get higher Absorbance for complex as in figure (8), after that it was decrease as we increase the volume of organic layer.…”

Section: Figure(7): the Effect Of Fe III Concentration On Complex For...mentioning

confidence: 90%

Determination of Cefalexin by Direct (UV- Vis) Spectrophotometer and Indirect(Flame Atomic Absorption) Technique

Mohammad¹

2017

IJPS

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A new method for the determination of the drug cefalexin in some Pharmaceuticals using (UV-Vis) and indirect Flame Atomic Absorption Spectrophotometer (FAAS) , Fe III should forms a chelating complex with cefalexin (CEX â€“Fe III) at pH (1-8) and the best pH for the formation of (CEX â€“Fe III) chelating complex was (2) .The complex extracted with Methanol and Dimethy-Sulphoxide .The mole-ratio method has been used to determine the structure of chelate (CEX - Fe III) and found to be 2:1 LM ( Ligand : Metal.) . Keywords : Cefalexin , chelating complex.

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Antibiotic as Ligand. Coordinating Behavior of the Cephalexin Towards Zn(II) and Cd(II) Ions

Cited by 25 publications

References 6 publications

Cu(II), Co(II), and Ni(II)–Antioxidative Phenolate–Glycine Peptide Systems: An Insight into Its Equilibrium Solution Study

Cu(II), Co(II), and Ni(II)–Antioxidative Phenolate–Glycine Peptide Systems: An Insight into Its Equilibrium Solution Study

Multiple Roles of Cu(II) in Catalyzing Hydrolysis and Oxidation of β-Lactam Antibiotics

Determination of Cefalexin by Direct (UV- Vis) Spectrophotometer and Indirect(Flame Atomic Absorption) Technique

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