“…Studies in chemical ecology show that opisthobranchs sequester secondary metabolites from prey, accumulate, concentrate, and distribute them in their tissues, and use them for their own defense (Carte and Faulkner, 1983;Paul et al, 1990;Becerro et al, 2001Becerro et al, , 2003. This strategy of sequestration, concentration, modification, and distribution of metabolites from the prey into the body of the predator is found widely in nudibranchs (Cimino and Ghiselin, 1999 and references therein), sacoglossans (Cimino and Ghiselin, 1998;Becerro et al, 2001), notaspideans (Teeyapant et al, 1993;Ebel et al, 1999;Becerro et al, 2003), and sea hares (Johnson and Willows, 1999). D. granulosa is a chemically defended sponge that produces a number of polybrominated diphenyl ethers (Becerro and Paul, 2004).…”