Antibiotic and antiparasitic residues in surface water of urban rivers in the Red River Delta (Hanoi, Vietnam): concentrations, profiles, source estimation, and risk assessment

Le, Nhu D.; Hoang, Anh; Hoang, Thi Thu Ha; Nguyen, Thi Anh Huong; Duong, Thi Thuy; Pham, Thi Mai Hương; Dat, Nguyen Tien; Hoang, Chung Van; Phung, Thi Xuan Binh; Le, Huu Tuyen; Tran, Cao-Son; Dang, Thu Hien; Tu, Vu Ngoc; Nguyen, Trong-Nghia; Le, Thi Phuong Quynh

doi:10.1007/s11356-020-11329-3

Cited by 27 publications

(14 citation statements)

References 54 publications

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“…19,31,32 . The concentrations of OFL in the surface waters of the northern basin and the inner estuary of the Seine River in Pakistan ranged from 0 to 6 ng/L, and these were roughly similar to those in the surface waters of the Yitong River in Changchun but much lower than those in the Red River in India [33][34][35] .…”

Section: Spatial and Temporal Distribution Characteristics Of Antibio...mentioning

confidence: 73%

Spatial and temporal distribution characteristics of antibiotics and heavy metals in the Yitong River basin and ecological risk assessment

Zhao

Wang

Qian

et al. 2023

Sci Rep

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Due to rapid socioeconomic development, antibiotic pollution and heavy metal pollution are receiving increasing amounts of attention. Both antibiotics and heavy metals in the environment are persistent and toxic, and the interactions between the pollutants create potential long-term hazards for the ecological environment and human health as mixed pollutants. In this study, the surface water of the Yitong River in Changchun was used as the research object, and the hazards associated with antibiotics and heavy metals in the surface water were assessed by analyzing the spatial and temporal distribution characteristics of antibiotics and heavy metals and by using ecological risk assessment and human health risk assessment models. The results showed that ofloxacin (OFL) and norfloxacin (NOR) varied seasonally according to the seasonal climate, with total concentrations ranging from 17.65 to 902.47 ng/L and ND to 260.49 ng/L for OFL and NOR, respectively, and from 8.30 to 120.40 μg/L, 1.52 to 113.41 μg/L and 0.03 to 0.04 μg/L for copper (Cu), zinc (Zn) and cadmium (Cd), respectively. In terms of spatial distribution, the concentration of antibiotics in the urban sections, which had intensive human activities, was higher than that in the suburban sections, while the concentration of heavy metals in the suburban sections, which had intensive agricultural operations, was greater than that in the urban section. Ecological risk evaluation showed that NOR and OFL were present in the water bodies at a high-risk level, Cd was at a low pollution level, and the heavy metal Cd was the primary pollutant associated with health risks toward for adults and children, and it was mainly at a medium risk level. Additionally, both antibiotics and heavy metals posed higher health risks for children than for adults.

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Section: Spatial and Temporal Distribution Characteristics Of Antibio...mentioning

confidence: 73%

Spatial and temporal distribution characteristics of antibiotics and heavy metals in the Yitong River basin and ecological risk assessment

Zhao

Wang

Qian

et al. 2023

Sci Rep

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“…Since the late 1990s, antibacterials have received particular attention due to their detection in surface and coastal waters and concerns about the emergence of antimicrobial resistance. High consumption and low absorption by humans and animals have caused them to be discharged to soil and receiving waters in their different manufacturing, consumption and disposal processes, with or without pretreatment in wastewater treatment plants becoming present in aquatic ecosystems at concentrations at the ng L − 1 range (Bojarski et al, 2020;da Le et al, 2021;Felis et al, 2020;Fernandez et al, 2021;Kovalakova et al, 2020). Although advanced oxidation processes and other treatments such as membrane bioreactors, bioelectrochemical systems and constructed wetlands have proven to be efficient for the removal of these compounds, they are not frequently used (Fernandez et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The antibacterials Ciprofloxacin (CIP), Sulfadiazine (SULF) and Trimethoprim (TRIM) have been chosen in our study due to their consumption and presence (in the range of ng-µg L − 1 ) in different environmental matrices (Chia et al, 2021;da Le et al, 2021;Fernandez et al, 2021;Kovalakova et al, 2020;Li et al, 2020) and negative effects reported in aquatic organisms (Fernandez et al, 2021). CIP and TRIM are used especially in the treatment of urinary tract infections in humans (Dougherty, 2011) and SULF in the mariculture industry and in humans (Li et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata).

Fernandez

Colás-Ruiz²,

Martı́nez-Rodrı́guez³

et al. 2022

Aquatic Toxicology

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“…In this study, seven major pharmaceutical residues in surface water and hospital wastewater, including carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, were analyzed using ultrahigh performance liquid chromatography (UPLC) combined with positive ionization tandem mass spectrometry (MS/MS) in multiple monitoring reaction mode. These compounds were commonly reported as the most popular antibiotics in Vietnam in recent publications [ 22 – 24 ]. Water sample was cleaned up with multimode solid phase extraction (cation exchange and reversed phase mode in the same solid phase extraction cartridge).…”

Section: Introductionmentioning

confidence: 99%

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater

Bui

Phung-Thi

et al. 2021

Journal of Analytical Methods in Chemistry

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In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. The method includes enrichment and clean-up steps by solid phase extraction using mix-mode cation exchange, followed by identification and quantification using an ultrahigh-performance liquid chromatography and tandem mass spectrometry and employing electrospray ionization (UPLC-ESI-MS/MS). Seven target compounds were separated on the reversed phase column and detected in multiple reaction monitoring (MRM) mode within 6 minutes. The present study also optimized the operating parameters of the mass spectrometer to achieve the highest analytical signals for all target compounds. All characteristic parameters of the analytical method were investigated, including linearity range, limit of detection, limit of quantification, precision, and accuracy. The important parameter in UPLC-ESI-MS/MS, matrix effect, was assessed and implemented via preextraction and postextraction spiking experiments. The overall recoveries of all target compounds were in the ranges from 55% to 109% and 56 % to 115% for surface water and hospital wastewater, respectively. Detection limits for surface water and hospital wastewater were 0.005–0.015 µg L−1 and 0.014–0.123 µg L−1, respectively. The sensitivity of the developed method was allowed for determination of target compounds at trace level in environmental water samples. The in-house validation of the developed method was performed by spiking experiment in both the surface water and hospital wastewater matrix. The method was then applied to analyze several surface water and hospital wastewater samples taken from West Lake and some hospitals in Vietnam, where the level of these pharmaceutical product residues was still missed. Sulfamethoxazole was present at a high detection frequency in both surface water (33% of analyzed samples) and hospital wastewater (81% of analyzed samples) samples.

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Antibiotic and antiparasitic residues in surface water of urban rivers in the Red River Delta (Hanoi, Vietnam): concentrations, profiles, source estimation, and risk assessment

Cited by 27 publications

References 54 publications

Spatial and temporal distribution characteristics of antibiotics and heavy metals in the Yitong River basin and ecological risk assessment

Spatial and temporal distribution characteristics of antibiotics and heavy metals in the Yitong River basin and ecological risk assessment

The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata).

Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater

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