Abstract:Infections
with Pseudomonas aeruginosa are a looming
threat to public health. New treatment strategies are needed to combat
this pathogen, for example, by blocking the production of virulence
factors like pyocyanin. A photoaffinity analogue of an antipyocyanin
compound was developed to interrogate the inhibitor’s molecular
mechanism of action. While we sought to develop antivirulence inhibitors,
the proteomics results suggested that the compounds had antibiotic
adjuvant activity. Unexpectedly, we found that th… Show more
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