Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole

Fang, Longxiang; Chen, Xi; Shan, Xiangbao; Qiu, Liping; Fan, Limin; Meng, Shunlong; Song, Chao

doi:10.1007/s11356-021-15253-y

Cited by 13 publications

(2 citation statements)

References 42 publications

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“…Moustafa et al [71] found a normal hepatic portion in Bacillusstrainprovided Nile tilapia, and this correlates with our fndings. Sulfamethoxazole is a fat-soluble antibiotic, and it increases triglycerides in fsh liver, which causes fatty liver [79]. Diferent treatment units in the current study also followed and remained consistent with the previous research.…”

Section: Discussionsupporting

confidence: 89%

Effects of Probiotics, Prebiotics, and Synbiotics as an Alternative to Antibiotics on Growth and Blood Profile of Nile Tilapia (Oreochromis niloticus)

Munni

Akther

Ahmed

et al. 2023

Aquaculture Research

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The purpose of this study is to compare the effects of probiotics, prebiotics, and their synergism against antibiotics on the growth performance and hematology of Nile tilapia (Oreochromis niloticus). The study was designed by using five treatments over 75 days in which TCon (control), TAnt (antibiotics: Cotrim vet), TPro (commercial probiotics: pond care), TPre (prebiotics: spirulina), and TSyn (synbiotic: probiotic and prebiotic) were used. All the treatments showed significant ( P < 0.05) improvements in growth and feed utilization parameters. The highest mean final growth was found in TSyn (13.79 ± 0.11) and then in TPre (13.61 ± 0.02), TPro (13.22 ± 0.12), TAnt (10.04 ± 0.7), and TCon (8.89 ± 0.19). Weight gain and specific growth rate were significantly ( P < 0.05) different between treatments. The food conversion ratio varied significantly ( P < 0.05) across treatments and the lowest value was observed in TPro (1.13 ± 0.021). The protein efficiency ratio (PER) was significantly ( P < 0.05) different between treatments and the highest value was in TPro (3.1 ± 0.05). The survival rate was not significantly ( P < 0.05) different between treatments. The highest white blood cell (WBC) counts were found in TSyn (12.63 ± 0.11) followed by TPre (12.6 ± 0.2), TPro (12.32 ± 0.12), TCon (12.16 ± 0.105), and TAnt (11.03 ± 0.46). The values of red blood cells and platelets were not statistically significant ( P < 0.05) among the different treatments. However, all treatments showed normal hepatocyte structure in liver tissue histology, and intense hepatic lipid vacuoles in TSyn indicated improved growth. The higher growth performance and feed utilization values were observed in probiotics, prebiotics, and their synergism units compared to antibiotic treatment. Therefore, probiotics, prebiotics, and their synergism can be used as an alternative to antibiotics in tilapia aquaculture.

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Section: Discussionsupporting

confidence: 89%

Effects of Probiotics, Prebiotics, and Synbiotics as an Alternative to Antibiotics on Growth and Blood Profile of Nile Tilapia (Oreochromis niloticus)

Munni

Akther

Ahmed

et al. 2023

Aquaculture Research

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“…To solve the problems generated by pathogens, antimicrobials and antiparasitics have been used as preventive and corrective measures ( Cao et al, 2022 ), but they have a consequent negative impact in the medium and long term on the environment. The antibiotics administration in high doses or throughout long periods has a severe affectation on microbial communities in both the fish and the environment, as well as triggering antibiotic resistance which can even worsen pathogen control ( Budiati et al, 2013 ; Fang et al, 2021 ); thus, such strategies could be a double-edged sword with immediate benefits with mid- or long-term negative consequences.…”

Section: Introductionmentioning

confidence: 99%

Microbiota plasticity in tilapia gut revealed by meta-analysis evaluating the effect of probiotics, prebiotics, and biofloc

Martinez-Porchas,

Preciado-Álvarez,

Vargas-Albores

et al. 2023

PeerJ

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Tilapia species are among the most cultivated fish worldwide due to their biological advantages but face several challenges, including environmental impact and disease outbreaks. Feed additives, such as probiotics, prebiotics, and other microorganisms, have emerged as strategies to protect against pathogens and promote immune system activation and other host responses, with consequent reductions in antibiotic use. Because these additives also influence tilapia’s gut microbiota and positively affect the tilapia culture, we assume it is a flexible annex organ capable of being subject to significant modifications without affecting the biological performance of the host. Therefore, we evaluated the effect of probiotics and other additives ingested by tilapia on its gut microbiota through a meta-analysis of several bioprojects studying the tilapia gut microbiota exposed to feed additives (probiotic, prebiotic, biofloc). A total of 221 tilapia gut microbiota samples from 14 bioprojects were evaluated. Alpha and beta diversity metrics showed no differentiation patterns in relation to the control group, either comparing additives as a group or individually. Results also revealed a control group with a wide dispersion pattern even when these fish did not receive additives. After concatenating the information, the tilapia gut core microbiota was represented by four enriched phyla including Proteobacteria (31%), Fusobacteria (23%), Actinobacteria (19%), and Firmicutes (16%), and seven minor phyla Planctomycetes (1%), Chlamydiae (1%), Chloroflexi (1%), Cyanobacteria (1%), Spirochaetes (1%), Deinococcus Thermus (1%), and Verrucomicrobia (1%). Finally, results suggest that the tilapia gut microbiota is a dynamic microbial community that can plastically respond to feed additives exposure with the potential to influence its taxonomic profile allowing a considerable optimal range of variation, probably guaranteeing its physiological function under different circumstances.

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The effects of a mixture of antibiotics on the intestinal microbiota and hepatic lipid deposition in hybrid grouper fed bile acids diet

Shi

et al. 2022

Aquaculture Reports

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Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole

Cited by 13 publications

References 42 publications

Effects of Probiotics, Prebiotics, and Synbiotics as an Alternative to Antibiotics on Growth and Blood Profile of Nile Tilapia (Oreochromis niloticus)

Effects of Probiotics, Prebiotics, and Synbiotics as an Alternative to Antibiotics on Growth and Blood Profile of Nile Tilapia (Oreochromis niloticus)

Microbiota plasticity in tilapia gut revealed by meta-analysis evaluating the effect of probiotics, prebiotics, and biofloc

The effects of a mixture of antibiotics on the intestinal microbiota and hepatic lipid deposition in hybrid grouper fed bile acids diet

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