Antibiotic Abuse Induced Histopathological and Neurobehavioral Disorders in Mice

Helaly, Ahmed Mohamed; El-Attar, Yomna Ahmed; Khalil, Mahmoud; Ghorab, Doaa Shams El-Din Ahmed; EL-Mansoury, Adel

doi:10.2174/1574886314666190612130921

Cited by 17 publications

(15 citation statements)

References 41 publications

(29 reference statements)

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“…The present study aimed to investigate the psychological influence of GM on the central nervous system after the streptomycin treatment of mice. Antibiotics have been used to treat or prevent bacterial infections, but sometimes they cause severe life-threatening side effects that increase the economic burden and mortality of the global population [ 48 , 49 ]. The main problem with antibiotics is that they do not fight against specific harmful bacteria, but instead, kill a variety of other beneficial microorganisms in the gut.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Escherichia coli Ameliorates Antibiotic-Associated Anxiety Responses in Mice

Park

Nagappan

et al. 2021

Nutrients

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Despite the beneficial actions of antibiotics against bacterial infections, the use of antibiotics is a crucial etiological factor influencing microbial dysbiosis-associated adverse outcomes in human health. Based on the assumption that gut microbial dysbiosis can provoke behavioral or psychological disorders, the present study evaluated anxiety-linked behavioral changes in a mouse model of streptomycin-induced dysbiosis. Measuring anxiety-like behavior using the light–dark box and elevated plus maze tests indicated that streptomycin treatment caused acute anxiety in mice. As an intervention for dysbiosis-associated distress, the probiotic strain Escherichia coli Nissle 1917 (EcN) was evaluated for its effects on streptomycin-induced behavioral changes in mice. EcN supplementation persistently ameliorated anxiety responses in mice with streptomycin-induced dysbiosis. As an outcome of anxiety, body weight changes were marginally affected by antibiotic treatment. However, mice supplemented with EcN displayed acute retardation of body weight gain, since EcN is known to reduce food intake and increase energy expenditure. Taken together, EcN treatment prominently counteracted streptomycin-induced anxiety in mice, with the metabolically beneficial retardation of body weight gain. The present model simulates psychological disorders in antibiotic users. As a promising intervention, EcN treatment can facilitate psychological relief under conditions of dysbiotic stress by blocking the pathologic gut–brain circuit.

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Section: Discussionmentioning

confidence: 99%

Probiotic Escherichia coli Ameliorates Antibiotic-Associated Anxiety Responses in Mice

Park

Nagappan

et al. 2021

Nutrients

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“…Disturbance of gut microbiots by antibiotics in an early age tends to alter neurodevelopment which may lead to functional bowel disorders later in life (Caputi et al, 2017). Another study also found that amoxicillin abuse caused gut microbiota dysbiosis and histopathological and neurobehavioral alterations in adult mice, which may explain the rising trend of neuropsychiatric diseases in antibiotics abusing countries (Helaly et al, 2019). Comparing the studies and findings, we find that antibiotic exposure leads to neurotoxicity in fetuses with a low dosage while antibiotic abuse in adults may also induce nerve injury, urging for prudent usage of antibiotics.…”

Section: Antibioticsmentioning

confidence: 96%

Connecting the dots: targeting gut microbiota in drug toxicity

Luo¹,

Zhou²

2020

Preprint

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Gut microbiota has been demonstrated to have a vast influence on human health in recent decades and its role in initiating, aggravating, or ameliorating diseases is emerging. Therapeutic strategies have therefore increasingly developed by targeting gut microbial modulation. Recently, its contribution to heterogeneous toxicological responses is also gaining attention, especially in drug-induced toxicity. Oral drugs interact directly with gut microbiota within the gastrointestinal tract and a number of them elicit toxicity mediated by intestinal microbiota. Present studies focus more on the unidirectional influence of how xenobiotics disturb intestinal microbial composition and function and consequently induce altered homeostasis. However, interactions between gut microbiota and xenobiotics are bidirectional and the impact of gut microbiota on xenobiotics especially on drugs should not be neglected. Thus, in this review, we intend to focus on how gut microbiota modulates drug toxicity by highlighting gut microbiota, microbial enzyme, and metabolites to proffer references for seeking common countermeasures in coping with drug toxicity by targeting gut microbiota. Moreover, we give a hypothesis that drugs capable of inducing gut dysbiosis tend to more or less impact the gut-connected organs as evidenced by the drug-induced hepatic encephalopathy, indicating an underlying link among the gut, liver, brain, and other possible organs in drug-induced toxicity.

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“…Apparently, bacteria develop multiple mechanisms of resistance against almost all the available antibiotics (Davies and Davies 2010 ; Munita and Arias 2016 ). The neurotoxic effect result from abuse of antibiotics works by both local and more prominent systemic mechanisms (Helaly et al 2019 ).…”

Section: Antibiotic Abusementioning

confidence: 99%

“…These abnormalities are called dysbiosis and can lead to autoimmune disorders, gastrointestinal disorders, allergies, infections, arthritis, asthma, cancer and obesity (Cardetti et al 2020 ). Abusing antibiotics by taking in excess modifies the gut microbiota and this is studied to be associated with the development of neurological and psychiatric disorders (Helaly et al 2019 ). In a bid to cut down the use of antibiotics amid the controlling of abuse of antibiotics and resistance, antimicrobial peptides (AMPs) in combination with some conventional antibiotics are promising (Liu et al 2020a , b ; Pang et al 2019 ).…”

Section: Antibiotic Abusementioning

confidence: 99%

The varying effects of antibiotics on gut microbiota

et al. 2021

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Antibiotics are lifesaving therapeutic drugs that have been used by human for decades. They are used both in the fight against bacterial pathogens for both human and for animal feeding. However, of recent, their effects on the gut microbial compositions and diversities have attracted much attention. Existing literature have established the dysbiosis (reduced diversity) in the gut microbiota in association with antibiotic and antibiotic drug doses. In the light of spelling out the varying effects of antibiotic use on gut microbiota, this review aimed at given an account on the degree of gut microbial alteration caused by common antibiotics. While some common antibiotics are found to destroy the common phyla, other debilitating effects were observed. The effects can be attributed to the mode of mechanism, the class of antibiotic, the degree of resistance of the antibiotic used, the dosage used during the treatment, the route of administration, the pharmacokinetic and pharmacodynamics properties and the spectrum of the antibiotic agent. Health status, stress or the type of diet an individual feeds on could be a great proportion as confounding factors. While it is understood that only the bacterial communities are explored in the quest to establishing the role of gut in health, other gut microbial species are somehow contributing to the dysbiosis status of the gut microbiota. Until now, long term natural fluctuations like diseases outbreaks and mutations of the strain might as well rendered alteration to the gut independent of antibiotic treatments.

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Antibiotic Abuse Induced Histopathological and Neurobehavioral Disorders in Mice

Cited by 17 publications

References 41 publications

Probiotic Escherichia coli Ameliorates Antibiotic-Associated Anxiety Responses in Mice

Probiotic Escherichia coli Ameliorates Antibiotic-Associated Anxiety Responses in Mice

Connecting the dots: targeting gut microbiota in drug toxicity

The varying effects of antibiotics on gut microbiota

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