Antibiofilm Potential of Metal Based Nanoparticles: Synthesis and Mode of Action

Abstract

Biofilm refers to a group of microbes colonizing together and often adhered to a surface. The adherence is attributed to secretion of polymeric substances comprising of extracellular DNA, proteins, and polysaccharides thereby limiting the access and inhibitory activity of existing antimicrobial agents. Biofilm are a major cause of acute infections and pose immense clinical threat especially in conditions employing the use of invasive devices thus being a major source of mortality and morbidity. Hence there is a dire need to develop alternative treatment against biofilm-related infections. Advances in nanotechnology has opened new horizons. Nanoparticles derived from various metal present promising candidates to ameliorate biofilms owing to their antioxidant potential.

Synthetic Approaches for Heteroannulated Chromones Fused Various Heterocyclic Systems

“…Chromones (4H-chromen-4-one, 4H-1-benzopyran-4-ones) serve as the basic structural motif of a highly important oxygen-containing heterocyclic systems, which are commonly found in various flavonoids that occur as natural products in the plant world. 1,2 Many chromone derivatives exhibit strong biological activity 3,4 such as antioxidants, [5][6][7] antimicrobial, 7 anti-HIV, 8 anti-inflammatory, 9,10 antitumor, 11 anticancer, 12 antiviral, 13 antiparkinson, 14 and have found applications as privileged structural motifs during the construction of various pharmaceutical molecules. 15,16 Electronic absorption spectra, quantum chemical studies, DFT calculations, and optical properties were investigated for chromone derivatives.…”