Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

A novel Nanocellulose-Gelatin-AS-IV external stent resists EndMT by activating autophagy to prevent restenosis of grafts

“…Hydrogels and NC are biocompatible. Their synthesis requires a washing step to remove potentially harmful cells and tissues [ [70] , [71] , [72] ]. If necessary, UV irradiation and ozone can sterilize hydrogels after preparation to minimize contamination by microorganisms such as bacteria and fungi [ 73 , 74 ].…”

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

“…The pulp cells co-cultured in the scaffolds show improved adhesion, spreading, cell capacity, and three-dimensional configurations [ 161 ]. Da Costa Sousa et al added poly(vinyl alcohol) to produce nanofiber, in which they incorporated the antibiotic and immunomodulatory peptide IDR-1002 [ 162 ]. This scaffold with SCAP was subsequently embedded in tooth fragment and subcutaneously implanted in mice, resulting in pulp-like tissue generation within the scaffold [ 162 ].…”

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

“…Recently, such antimicrobial peptides (IDR-1002) were added to PVA/chitosan nanofibers together with the antimicrobial drug – ciprofloxacin for dental pulp regeneration and revascularization. 86 However, they were not incorporated into the hydrogel counterparts after carrying out the biodegradability tests for the fibers and the hydrogels. A specific fiber group exhibited an optimal time for degradation (21 days) for dental pulp reconstruction.…”