ANTIBACTERIALACI'IVITY OF STEROIDSAPONINES OF THE WHITRE FLOWER ONION (ALLIUM LEUCANTHUM CKCI.l)

Phytochemical and Pharmacological Review of Allium Species from Georgia

“…Yucagenin, Agigenin 24 Cytotoxic activity 20 Antifungal activity Antileishmanial activity 25 Antibacterial activity 26 Allium paradoxum Astragalin; 2-Methoxy tyrosol 27 Dioscin related saponins 28 Leishmanicidal activity, 28 Antioxidant activity, 29 Hepatoprotective effect, 30 Antiplasmodial activity, 31 Analgesic activity 32 Nephroprotective effect 33 Allium rotundum…”

“…Glycosides of β-chlorogenine displayed more potent activity than agigenin glycosides. 26 Phytochemical studies of A. paradoxum, particularly its saponin constituents, led to the isolation and identification of a dioscin-related steroidal saponin from the plant's bulbs by Rezaee et al This compound exhibited significant leishmanicidal effects on promastigotes of L. majorat in both 10 and 50 µg/mL concentrations. 28 Further investigation into A. leucanthum by Mskhiladze et al found that the spirostanol fraction was ten times more active against Leishmania amastigotes than human cells.…”