Antibacterial Thymol Derivatives Isolated from Centipeda minima

He, Liang; Bao, Fukai; Dong, Xiaoping; Tan, Rui; Zhang, Caijun; Lü, Qing; Cheng, Yong‐Xian

doi:10.3390/12081606

Cited by 57 publications

(32 citation statements)

References 18 publications

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“…Interestingly, this genus has been used as substitutes for oregano, which also contains thymol as commented before (Tucker & DeBaggio, ). Alternatively, the species Centipeda minima (Asteraceae), commonly used in Chinese folk medicine, is rich in derivatives of thymol (Liang et al, ). Therefore, all the essential oils of these species can be used as natural sources of thymol and standardized for further uses.…”

Section: Resultsmentioning

confidence: 99%

Thymol, thyme, and other plant sources: Health and potential uses

Salehi

Mishra

Shukla

et al. 2018

Phytotherapy Research

351

207

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Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. This plant, native to Mediterranean regions, is commonly used as a culinary herb and also with a long history of use for different medicinal purposes. Nowadays, thymol and thyme present a wide range of functional possibilities in pharmacy, food, and cosmetic industry. The interest in the formulation of pharmaceuticals, nutraceuticals, and cosmeceuticals based on thymol is due to several studies that have evaluated the potential therapeutic uses of this compound for the treatment of disorders affecting the respiratory, nervous, and cardiovascular systems. Moreover, this compound also exhibits antimicrobial, antioxidant, anticarcinogenesis, anti-inflammatory, and antispasmodic activities, as well as a potential as a growth enhancer and immunomodulator. In the present review, these bioactivities have been covered because some of them can contribute to explain the ethnopharmacology of thymol and its main source, T. vulgaris. Other important aspects about thymol are discussed: its toxicity and bioavailability, metabolism, and distribution in animals and humans.

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Section: Resultsmentioning

confidence: 99%

Thymol, thyme, and other plant sources: Health and potential uses

Salehi

Mishra

Shukla

et al. 2018

Phytotherapy Research

351

207

View full text Add to dashboard Cite

show abstract

“…In some Inula, Doronicum and Pulicaria species, thymyl derivatives rather than sesquiterpenoids are the major root constituents. [20][21][22][23] A review by Talavera-Aleman and collaborators 24 estimated that only 10% of known functionalized thymyl derivatives have been employed in biological testing, showing vast array of diverse activities, such as antimicrobial 4,5,22,[25][26][27] (several papers reporting inhibitory activity against plants' pathogenic fungi 22,26 ), antioxidant, 28 antinociceptive, 29 anti-parasitic (antileishmanial), 30,31 antiprotozoal, 32 insecticidal 33 and piscicidal 34 activity. The usefulness of thymyl derivatives as transdermal drug delivery enhancers has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial Activity and in silico Studies on Thymol Esters

Lazarević

Kolarević

Stojanović

et al. 2017

ACSi

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Derivatisation of parent structure in terpenoids often results in enhancement of biological activity of newly obtained compounds. Thymol, a naturally occurring phenol biosynthesized through the terpene pathway, is a well known biocide with strong antimicrobial attributes and diverse therapeutic activities. We have aimed our study on a single modification of phenolic functionality in thymol in order to obtain a small focused library of twenty thymyl esters, ten of which were new compounds. All compounds were involved in in vitro antimicrobial testing. Another important aspect of current study was implementation of in silico calculation of physico-chemical, pharmacokinetic and toxicological properties, which could be helpful by giving an additional guidance in further research.

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“…[20] The silanes 4 were additionally functionalized to form chiral five-membered silyl rings (6) without loss of enantioselectivity using iridium-catalyzed intramolecular dehydrogenation. [21] We determined the absolute configuration of hydrosilylation products by X-ray analysis of the compounds 6 b and 6 v. [22] The phenol derivatives with chiral motifs at the ortho-position are also core structures and useful precursors [23] for bioactive natural products, [24] and 7 b was obtained in 86 % yield by oxidative hydrolysis [20] of the cyclic silane 6 b. Chiral 3-substituted 2,3dihydrobenzofurans [25] are precursors for the anticancer active (À)-thespesone [26] or single-stranded abiotic metallofoldamers. [27] (S)-(+)-3-Methyl dihydrobenzofuran (8 b) was obtained through an intramolecular Mitsunobu reaction [20] of 7 b in 62 % yield (the product was highly volatile).…”

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confidence: 99%