Antibacterial therapy of vulgar acne

Snarskaya, Elena S.; Снарская, Е C

doi:10.25208/0042-4609-2019-95-5-58-67

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Acne vulgaris is characterized by clinical diversity. According to the classification of the American Academy of Dermatovenereology, mild, moderate, severe and very severe degrees of severity of the disease are distinguished [10]. Also, acne is a chronic dermatosis, sometimes developing long-term non-healing wound defects and post-acne skin changes [2].…”

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confidence: 99%

Morphological Efficacy Evaluation of Gel With Carbon Dioxide Extract of Hops in Case of Complicated Wound Infection Acne Vulgaris

Moiseienko¹,

Torianyk²,

G.Ye.³

et al. 2021

Wiad Lek

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The aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops. Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Group 1 consisted of intact animals (n=6). Group 2 was represented by animals (n=6), which had hair epilation on the dorsal surface of the body in an area of 1 сm2, followed by application of 2 ml of placebo gel to this area. Group 3 included animals (n=6), which were epilated on the dorsal surface of the body in an area of 1 сm2 and applied 2 ml of 1 % gel with carbon dioxide extract of hops. Group 4 included rats (n=6), which were epilated on the dorsal surface of the body in an area of 1 сm2 and simulated thermal damage. Group 5 was represented by 10 rats, who were epilated on the dorsal surface of the body in an area of 1 сm2, simulated thermal damage, followed by applying 2 ml of placebo gel to the wound surface. Group 6 included rats (n=10), who underwent measures similar to group 5, followed by application of 2 ml of 1 % gel with carbon dioxide extract of hops to the wound surface. In group 7, there were 6 rats, which were epilated on the dorsal surface of the body in an area of 1 сm2, thermal damage to the skin with underlying soft tissues was simulated, followed by application to the wound surface the reference strains of Staphylococcus aureus, Streptococcus pyogenes, Proteus vulgaris, Propionibacterium acnes, Escherichia coli, Pseudomonas aeruginosa, Malassezia slooffiae, Malassezia pachydermatis, Candida albicans, Candida parapsilosis. In groups 8 and 9, there were 15 rats each, which underwent measures similar to group 7, followed by applying 2 ml of placebo gel on its surface on the next day after infection of the wound in group 8, and in group 9 – 2 ml of 1 % gel with carbon dioxide extract hops. The material for the study was the skin with underlying soft tissues. It was used histological, histochemical, morphometric and statistical methods. Results: This experimentally created gel with carbon dioxide extract of hops activates separation processes of horny masses from the surface of the epidermis, cleaning the pores of the skin; stimulating the proliferative activity of the epidermis, which is located in the marginal sections of the wound or covers the surface of the regenerate; activating the processes of cleansing the wound from necrotic tissue; activating the growth and maturation of granulation tissue with its subsequent transformation into connective tissue. It has anti-inflammatory, bactericidal and antimycotic effects, normalizing skin microbiocenosis. Conclusions: The complex morphological study has showed that gel with carbon dioxide extract of hops is a highly effective drug in treatment of severe and very severe acne vulgaris, characterized by the development of deep and infected wound defects.

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Morphological Efficacy Evaluation of Gel With Carbon Dioxide Extract of Hops in Case of Complicated Wound Infection Acne Vulgaris

Moiseienko¹,

Torianyk²,

G.Ye.³

et al. 2021

Wiad Lek

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“…В заключение приводим результаты исследования Е. С. Снарской по эффективности и безопасности Минолексина ® при лечении акне [15]:…”

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Minocycline in acne system therapy

Самцов

Викторович²

2020

Vestnik dermatologii i venerologii

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Systemic antibiotics in combination with topical retinoids and benzoyl peroxide are first-line drugs for the treatment of moderate to severe acne. The systemic antibiotic Minocycline has a wide spectrum of action against gram + and gram-organisms, including strains resistant to penicillins and cephalosporins. A pronounced bacteriostatic effect is achieved by a high level of lipophilicity, rapid penetration through the lipid layer of bacteria and intensive accumulation in the sebaceous glands. Minolexin is a highly effective and safe medication for the treatment of moderate to severe acne and can be recommended for practical use in outpatient practice.

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Assessment of biofilmforming activity of Fusarium solani isolated from patients’ skin

Валиева

Lisovskaya

Исаева

2021

CMAC

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Objective. To study pathogenic factors (adhesion and biofilm formation) in F. solani isolated from skin of patients Materials and methods. A total of 86 strains of F. solani isolated from the skin of patients with a diagnosis of L30.3 “Infectious dermatitis” were selected. The reference strain F. solani F-819 was used for quality control. Samples were collected using a sterile cotton swab from an area of 5 × 5 cm. The primary incubation was at Saburo media (HiMedia, India). Determination of the adhesion of the strains was carried out in the previously developed model from a nitrocellulose plate. Biofilms were formed using the method by Pierce C. et al. in 96-well flat bottom polystyrene plates. The efficiency of F. solani biofilms was assessed by the optical density of the total biomass (staining with Cristal Violet extract) and exopolysaccharide matrix (staining with Congo Red extract). Results. The studied F. solani strains were divided into two groups: isolates from patients with acute course of the disease (group I, n = 54), and isolates from patients with chronic relapsing disease (group II, n = 32). The adhesion of microconidia of isolates from patients with a chronic form is higher compared to isolates from patients with an acute form (p = 0.013) and the reference strain (p = 0.007). 26 (81.2%) isolates from patients with chronic form of the disease and 19 (35.2%) isolates from patients with acute form had an increased ability to form biofilms. The total biofilm mass was higher in F. solani isolates from the patients with chronic disease than that in isolates from the patients with acute course of the disease, and already matured on the 4th day of incubation. An increase in number of exopolysaccharide matrix was observed in F. solani isolated from patients with chronic disease on the 5th day of incubation, which led to increase in total biofilm mass. Conclusions. This study showed that F. solani can form biofilms. Significant differences in adhesion and biofilm formation between clinical strains of F. solani isolated from patients with various forms of the disease were found.

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Antibacterial therapy of vulgar acne

Cited by 3 publications

References 6 publications

Morphological Efficacy Evaluation of Gel With Carbon Dioxide Extract of Hops in Case of Complicated Wound Infection Acne Vulgaris

Morphological Efficacy Evaluation of Gel With Carbon Dioxide Extract of Hops in Case of Complicated Wound Infection Acne Vulgaris

Minocycline in acne system therapy

Assessment of biofilmforming activity of Fusarium solani isolated from patients’ skin

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