Antibacterial, Synergistic and β-lactamase Inhibitory Activity of Oroxylem indicum: An In vitro and Molecular Interaction Study

Abstract

Aims:The study was aimed to evaluate the antibacterial, synergistic and β-lactamase inhibitory potential of O. indicum against ampicillin resistant and Extended Spectrum βlactamase (ESBL) producing bacterial strains. Methods: Bacterial strains were screened for ampicillin resistance and ESBL production by disk diffusion method and modified double disc synergy test respectively. Antibacterial and synergistic activities of O. indicum methanol extract and ethyl acetate sub fraction of methanol extract were explored by agar well diffusion method and Checkerboard method

Synergistic action of 6-gingerol as an adjuvant to colistin for susceptibility enhancement in multidrug-resistant Klebsiella pneumoniae isolates

“…29,30 Several edible natural products and food ingredients have been recently found to augment the antibacterial efficacy of nitrofurantoin and clindamycin. 32…”

“…29,30 Several edible natural products and food ingredients have been recently found to augment the antibacterial efficacy of nitrofurantoin and clindamycin. 32 Herein, we screened phytocompounds of Z. officinale using molecular docking techniques. Based on its pharmacological properties, we identied 6-gingerol as the most promising drug candidate to target the AcrB efflux pump protein.…”