Antibacterial Substance From Carica papaya Fruit Extract

Ac, Emeruwa

doi:10.1021/np50020a002

Cited by 134 publications

(72 citation statements)

References 1 publication

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“…Table 14 showed that the Minimum Inhibitory Concentrations (MIC) of the extracts ranged from -0.09 to 1.6. These MIC results correlate with reports that microorganisms vary widely in the degree of their susceptibility (Emeruwa, 1982;El Faraly et al, 1983). Antimicrobial agents with low activity against an organism have high minimum inhibitory concentration while a highly active microbial agent gives low MIC.…”

Section: S/n Clinical Isolatessupporting

confidence: 87%

Antimicrobial Effect of the Leaf Extracts of <i>Moringa oleifera</i> on Some Selected Clinical Bacterial Isolates

Adetitun¹,

Araoye²,

Akinyanju³

et al. 2013

Agrosearch

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Section: S/n Clinical Isolatessupporting

confidence: 87%

Antimicrobial Effect of the Leaf Extracts of <i>Moringa oleifera</i> on Some Selected Clinical Bacterial Isolates

Adetitun¹,

Araoye²,

Akinyanju³

et al. 2013

Agrosearch

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“…They also concluded that antimicrobial activity against both gram-negative and gram-positive bacteria is an indication that the Carica papaya is a potential source for production of a broad-spectrum bactericide. Moreover, Emeruwa (1982) supported that Carica papaya fruit extract had antibacterial activity against both gram-positive and gram-negative bacteria like E. coli and S. aureus. He also suggested that the site of action of the antibacterial was at cell wall since the cell morphology appeared to be changed.…”

Section: Introductionmentioning

confidence: 72%

Bactericidal Effects of Natural Tenderizing Enzymes on Escherichia Coli and Listeria monocytogenes

Eshamah¹,

Han²,

Naas³

et al. 2013

JFR

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The objective of this study was to determine the antimicrobial activity of proteolytic, meat-tenderizing enzymes (papain and bromelain) against E. coli and L. monocytogenes at three different temperatures (5, 25 and 35°C). Two overnight cultures of E. coli JM109 and L. monocytogenes were separately suspended in 1% peptone water and exposed to a proteolytic enzyme (papain or bromelain) at three different temperatures. Bromelain concentrations (4 mg/ml) and (1 mg/ml) tested at 25°C against E. coli and L. monocytogenes, respectively, were the most effective concentrations tested reducing populations by 3.37 and 5.7 log CFU/ml after 48 h, respectively. Papain levels of (0.0625 mg/ml) and (0.5 mg/ml) were the most effective concentration tested at 25°C against E. coli and L. monocytogenes, respectively, reducing populations by 4.94 and 6.58log CFU/ml after 48h, respectively. Interestingly, the lower papain concentration tested (0.0625 mg/ml) was more effective than the higher concentration (0.5 mg/ml) against E. coli at all three temperatures. As expected, the temperature was directly related to enzyme efficacy against both E. coli and L. monocytogenes.

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“…6 Other preparation in the market is papain urea chlorophylline copper complex which acts by inhibiting hemaglutination, inflammatory properties of protein degradation and decreases pain and wound odour. 7 The wound healing property of papaya is attributed to the endolytic plant enzyme papain. 8 Latex from raw papaya fruit is rich in papain.…”

Section: Resultsmentioning

confidence: 99%

Comparative study of papaya dressing versus normal saline dressing in healing of ulcers

et al. 2017

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Background: Chronic non-healing wounds pose a remarkable challenge to health professionals and drain our resources. In recent years, prevalence of diabetic foot ulcers is growing at epidemic proportion in India and worldwide. There are various modalities available for wound debridement. In present study, authors have compared two debridement methods, one which we use regularly in their hospital, wet to dry normal saline dressing and enzymatic debridement with papaya.Methods: This was a randomized, comparative interventional study of 100 patients carried out in Kilpauk Medical College Hospital from August 2013 to August 2014 to compare to efficacy of papaya dressing over normal saline dressing in chronic non-healing wounds.Results: The mean reduction in slough/necrotic tissue in at time of inclusion in study and four week after the study was assessed. In saline dressing, mean reduction was 13.156, standard deviation 3.4558. The mean reduction in slough/necrotic tissue in papaya dressing 10.5, standard deviation 0.7071. There was significant difference in percentage reduction in slough/necrotic tissue within the two groups. Similarly, for the cases with active ulcer, the size assessment at the time of inclusion in the study and three week after was again analysed using student t-test and the mean ulcer size in papaya dressing 2.5062 and standard deviation 1.504. Mean ulcer size in normal saline dressing 2.1564 and standard deviation 1.2961.Conclusions: Present study concluded that favourable and significant ulcer healing rate with improvement and reduction in clinical severity suggests that enzymatic debridement with papaya dressing plays an important role in management of chronic non-healing ulcers.

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Antibacterial Substance From Carica papaya Fruit Extract

Cited by 134 publications

References 1 publication

Antimicrobial Effect of the Leaf Extracts of <i>Moringa oleifera</i> on Some Selected Clinical Bacterial Isolates

Antimicrobial Effect of the Leaf Extracts of <i>Moringa oleifera</i> on Some Selected Clinical Bacterial Isolates

Bactericidal Effects of Natural Tenderizing Enzymes on Escherichia Coli and Listeria monocytogenes

Comparative study of papaya dressing versus normal saline dressing in healing of ulcers

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