Antibacterial, SOD mimic and nuclease activities of copper(II) complexes containing ofloxacin and neutral bidentate ligands

Abstract

Drug-based mixed-ligand copper(II) complexes of type [Cu(OFL)(

A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile

“…Furthermore, recent findings have shown that complexes of copper(II) and 5-NP act synergistically with ofloxacin, decreasing bacterial MICs to this fluoroquinolone in Gram-negative but not Gram-positive species [13]. To investigate the activity dependence of the nitro-substituted daughter molecule on chelation, various concentrations of separate metal solutions were added to growth media as described and the OD 600 was measured to determine increased MICs of 5-NP in the presence of these compounds.…”

In vitro DNA and BSA-binding, cell imaging and anticancer activity against human carcinoma cell lines of mixed ligand copper(II) complexes

“…The planner heterocyclic molecule of 1,10-phenanthroline-5,6-dione is a kind of polypyridyl ligands, which plays an important role both chemists and biochemists. Copper(II) complexes of phen-dione have shown mainly antibacterial activity against diverse microorganisms [15] nuclease activity [16], good affinity in DNA binding [17] and anticancer activity against human cancer cells [18].…”