Antibacterial resistance: Current problems and possible solutions

Sharma, Rashmi; Sharma, C. L.; Kapoor, Bharat

doi:10.4103/0019-5359.15091

Cited by 97 publications

(79 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since facilities for microbiological studies at the first contact physician/surgeon are usually not available in district hospitals/smaller cities in India, indiscriminate antimicrobial therapy (i.e. without establishing the aetiology of the infection) eradicates susceptible Gram-positive cocci and, as a result, selects resistant Gram-positive cocci and Gram-negative bacilli, as well [23,24] .…”

Section: Discussionmentioning

confidence: 99%

Changing microbiological profile of pathogenic bacteria in diabetic foot infections: time for a rethink on which empirical therapy to choose?

et al. 2010

View full text Add to dashboard Cite

Aims/hypothesis We studied the bacterial aetiology and antibiotic sensitivity pattern of diabetic foot ulcers in India. Methods Records of 447 hospitalised patients between 1991 and 2008 were retrospectively analysed between two time periods (before and after 1999) to compare bacterial aetiology and antimicrobial sensitivity patterns. The first three consecutive cultures from the same wound during treatment were evaluated. Results Of 1,632 cultures, 66% were polymicrobial, 23% monomicrobial and 11% sterile. In the monomicrobial group, 14% (n=228) of cultures were Gram-negative, whereas 9% (n=147) were Gram-positive. The most common pathogens in the first culture were Pseudomonas aeruginosa (20.1%), Staphylococcus aureus (17.2%) and Escherichia coli (16.3%). Results for the third cultures showed persistence of P. aeruginosa (15.3%) and E. coli (14.2%). Gramnegative isolates dominated over Gram-positive ones (25.3% vs 15.1%, p<0.05). Antibiotic sensitivity patterns before and after 1999 were: piperacillin-tazobactam 74% vs 66% (p<0.005), imipenem 77% vs 85% (NS), cefoperazone-sulbactam 47% vs 44% (p<0.005), amikacin 62% vs 78% (NS), ceftriaxone 41% vs 36% (p<0.005), amoxicillinclavulanate 51% vs 43% (p<0.05) and clindamycin 43% vs 36% (p<0.005), respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Changing microbiological profile of pathogenic bacteria in diabetic foot infections: time for a rethink on which empirical therapy to choose?

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Apenas metade dos isolados foram sensíveis à neomicina e à estreptomicina. O fraco desempenho desses fármacos pode ser creditado ao seu uso intensivo em medicina veterinária, muitas vezes de forma abusiva, indiscriminada e sem respaldo em testes de sensibilidade (Sharma et al, 2005), o que aumenta a pressão de seleção para linhagens bacterianas multirresistentes a antimicrobianos, inclusive de uso humano, como é o caso da ciprofloxacina (Andriole, 2005). Como consequência, há problemas de saúde pública relacionados ao surgimento de animais reservatórios de cepas multirresistentes para seres humanos contactantes.…”

Section: Resultsunclassified

Septicemia decorrente de pododermatites em canários de cor (Serinus canarius)

Borsa

Sanches

Oliveira

2013

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

RESUMORelataram-se um surto de pododermatite e quadro septicêmico em aves de um canaril comercial. Quarenta e quatro canários de cor foram escolhidos de forma aleatória, sem distinção de sexo, idade ou cor, os quais vieram a óbito naturalmente, após terem sido afetados pela pododermatite, sem que tivessem se submetido a tratamento prévio. As aves mortas foram encaminhadas para o exame necroscópico, onde amostras de tecidos das áreas afetadas foram colhidas para exames microbiológico, micológico e histológico. Todas as aves necropsiadas apresentavam pododermatite, com inflamação em um ou mais dedos, de aspecto nodular, com ou sem presença de úlceras ou necrose. Staphylococcus aureus plasma coagulase positivo foi isolado dos pés e do fígado de todas as aves. Foi observado que todas as linhagens isoladas foram resistentes aos antimicrobianos da classe das penicilinas (penicilina G e ampicilina) e parcialmente sensíveis ou resistentes à ciprofloxacina. Apenas metade dos isolados foram sensíveis à neomicina e à estreptomicina. Problemas de saúde pública podem estar relacionados ao surgimento de animais reservatórios de cepas multirresistentes para seres humanos contactantes, como neste caso. (Blasina, 2011), há três grupos de classificação para os canários: os de cor, os de porte e os de canto. Os Recebido em 9 de setembro de 2011 Aceito em 4 de setembro de 2012 E-mail: driborsa@gmail.com mais populares são os canários de cor, em razão da facilidade de reprodução e da riqueza de plumagens. Embora haja a exigência de rigorosos padrões de manejo e sanidade para a criação dessas aves, diversos criadores têm enfrentado taxas elevadas de mortalidade em seus plantéis, atribuídas a doenças que outrora não eram consideradas comuns na canaricultura.

show abstract

“…22,26 The resistance exhibited by E.coli to aminoglycosides varies. In this study, 19% gentamicin resistance in non-ESBL producing and 1% resistant in ESBL producing E.coli was observed but 37.5% resistance to gentamicin was reported in another study.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of antibiotics against a major uropathogen- Escherichia coli and its biofilm assay by phenotypic methods

2016

View full text Add to dashboard Cite

INTRODUCTIONUrinary tract infection (UTI), an inflammatory disease occurs due to high multiplication of pathogenic microbes in the urinary system, altering the perfect function of urinary tract and kidney. The bacterial UTI is the second most serious health problem and causing morbidity. 1About 50% -80% of population endures UTI in their lifetime; 20% -50% will have recrudescent infections. 2Globally 150 million people are UTI diagnosed each year and $6 billion high expenditure in all age groups. This infection focuses towards young, sexually active women than men, though the prevalence in elderly men and women are similar. A study conducted in US has estimated that around 40% -50% of healthy adult women will experience this infection. 3Escherichia coli commensal of the colon via symbiotic relationship causes intestinal infection opportunisticaly and a common cause of extra intestinal infection as UTI accounting for up to 80% of community acquired UTI's making it to consider as a major uropathogen. E.coli has ABSTRACT Background: Urinary tract infection (UTI), an inflammatory disease occurs to a high multiplication of pathogenic microbes in the urinary system. Escherichia coli, a major uropathogen accounting for up to 80% UTI. Activity of antibiotics against E.coli is decreasing due to enzymatic, genetic and various other factors resulting in multidrug resistance. Biofilm is a great threat as it interferes antibiotic therapy, undergoes gene transformation, making the bacteria more virulent. Objectives of the study were to isolate the E. coli from the urine sample of symptomatic UTI patients, to study the effectiveness of antibiotics against E.coli by antibiotic susceptibility pattern, ESBL detection and to biofilm phenotype assay by four different methods. Methods: A total of 400 urine samples from symptomatic UTI patients, October 2015 to March 2016 and processed. E.coli was isolated and antibiotic susceptibility was done as per CLSI guidelines. Biofilm detection by a) Congo red agar (CRA), b) Modified Congo red agar (MCRA), c) Tube adherence assay, d) Microtitre plate method. Results: A total of 100 E. coli (69%) was obtained from 400 samples, 49% were ESBL producers and 84% shows multi drug resistant. Biofilm positive isolates shows 70% positivity by CRA, 91% by MCRA, 57% in tube adherence assay and 99% via microtitre plate method. Conclusions: Resistance to antibiotics ladder is increasing and it's necessary to take actions to reduce its hindrance in the future. Advanced studies in biofilm will help to prevent the more virulence without any critical complications in therapy.

show abstract

Antibacterial resistance: Current problems and possible solutions

Cited by 97 publications

References 2 publications

Changing microbiological profile of pathogenic bacteria in diabetic foot infections: time for a rethink on which empirical therapy to choose?

Changing microbiological profile of pathogenic bacteria in diabetic foot infections: time for a rethink on which empirical therapy to choose?

Septicemia decorrente de pododermatites em canários de cor (Serinus canarius)

The effectiveness of antibiotics against a major uropathogen- Escherichia coli and its biofilm assay by phenotypic methods

Contact Info

Product

Resources

About