Antibacterial resin-based composite containing chlorhexidine for dental applications

Boaro, Letícia Cristina Cidreira; Campos, Luiza M. P.; Varca, Gustavo H.C.; Santos, Tiago C. dos; Marques, Pamela Adeline; Sugii, Mari Miura; Saldanha, Nathalia Ramaldes; Cogo‐Müller, Karina; Brandt, William Cunha; Braga, Roberto Ruggiero; Parra, D.F.

doi:10.1016/j.dental.2019.03.004

Cited by 59 publications

(62 citation statements)

References 44 publications

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“…They concluded that impregnation of ZnO@m-SiO 2 and silanized SiO 2 showed excellent mechanical properties with antimicrobial activity. Letícia Cristina Cidreira Boaro et al [107] developed dental composite with Montmorillonite (MMT) and CHX, which showed significant antibacterial activity against S. mutans, P. gingivalis and S. Aureus without compromising mechanical properties. In a few studies [108,109], to achieve long term effect of antibacterial properties, immobilized bactericide filler were successfully incorporated.…”

Section: Characteristics Of Dental Materialsmentioning

confidence: 99%

Resin based restorative dental materials: characteristics and future perspectives

Pratap

Gupta

Bhardwaj

et al. 2019

Japanese Dental Science Review

214

169

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This review article compiles the characteristics of resin based dental composites and an effort is made to point out their future perspectives. Recent research studies along with few earlier articles were studied to compile the synthesis schemes of commonly used monomers, their characteristics in terms of their physical, mechanical and polymerization process with selectivity towards the input parameters of polymerization process. This review covers surface modification processes of various filler particles using silanes, wear behaviour, antimicrobial behaviour along with its testing procedures to develop the fundamental knowledge of various characteristics of resin based composites. In the end of this review, possible areas of further interests are pointed out on the basis of literature review on resin based dental materials.

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Section: Characteristics Of Dental Materialsmentioning

confidence: 99%

Resin based restorative dental materials: characteristics and future perspectives

Pratap

Gupta

Bhardwaj

et al. 2019

Japanese Dental Science Review

214

169

View full text Add to dashboard Cite

show abstract

“…Zinc oxide [9,12,13], titanium dioxide [14,15], calcium phosphate [16,17], gold, and silver [18,19] are the most popular examples of the first group. The latter group is represented by antibiotics [20], chlorhexidine [9,21,22], furanone, ursolic acid, benzalkonium chloride, triclosan, and methacryloyloxydodecyl pyridinium bromide [9]; however, toxic responses of tissues adjacent to the reconstructions modified with these substances are often reported [12][13][14][15][16][17][18][19][20][21][22]. chloride, triclosan, and methacryloyloxydodecyl pyridinium bromide [9]; however, toxic responses of tissues adjacent to the reconstructions modified with these substances are often reported [12][13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Mechanical Properties of Bis-GMA/TEGDMA Dental Composite Resins Enriched with Quaternary Ammonium Polyethylenimine Nanoparticles

2021

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Modification of dental monomer compositions with antimicrobial agents must not cause deterioration of the structure, physicochemical, or mechanical properties of the resulting polymers. In this study, 0.5, 1, and 2 wt.% quaternary ammonium polyethylenimine nanoparticles (QA-PEI-NPs) were obtained and admixed with a Bis-GMA/TEGDMA (60:40) composition. Formulations were then photocured and tested for their degree of conversion (DC), polymerization shrinkage (S), glass transition temperature (Tg), water sorption (WS), solubility (SL), water contact angle (WCA), flexural modulus (E), flexural strength (σ), hardness (HB), and impact resistance (an). We found that the DC, S, Tg, WS, E, and HB were not negatively affected by the addition of QA-PEI-NPs. Changes in these values rarely reached statistical significance. On the other hand, the SL increased upon increasing the QA-PEI-NPs concentration, whereas σ and an decreased. These results were usually statistically significant. The WCA values increased slightly, but they remained within the range corresponding to hydrophilic surfaces. To conclude, the addition of 1 wt.% QA-PEI-NPs is suitable for applications in dental materials, as it ensures sufficient physicochemical and mechanical properties.

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“…The presence of bacteria with pathogenic potential in the margin of the prosthesis can initiate an inflammatory response in gingival tissue [6]. Several attempts have been made to decrease the bacterial adherence and plaque accumulation on the PMMA-based restorations by adding an antibacterial agent to the composition [7,8,9,10]. Chlorhexidine (CHX) is a widely used antimicrobial agent in dentistry due to its broad spectrum of antibacterial effects [11].…”

Section: Introductionmentioning

confidence: 99%

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Mai

Kim

Hyun

et al. 2019

JCM

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Chlorhexidine (CHX) has been incorporated into the composition of polymethyl methacrylate (PMMA) dental restorations to enhance their antimicrobial performance. However, the controlled delivery of CHX remains a challenge. Although previous findings with pure silica or polymer coatings demonstrated the resistance to bacterial adhesion, they did not provide antibacterial activity beyond the coated surface. Polydimethylsiloxane (PDMS) and mesoporous silica nanoparticles (MSNs) are widely used in biomedical science as a transfer medium in drug delivery systems. Here, the MSNs are used to encapsulate CHX, and the combination is added to PDMS. A thin coating film is formed on the PMMA, using oxygen plasma and thermal treatment. The liquid chromatography analysis shows that the coating film has high encapsulation efficiency and loading capacity, with a slow and stable release rate of CHX. The cytotoxicity tests also show that the coating does not affect the proinflammatory cytokines, cellular mitotic activity, or apoptotic cell death. The ability of the coating to release CHX indicates that the coating may even be effective against bacteria that are not directly in contact with the surface. This antibacterial protective film is expected to be a novel method to inhibit bacterial activity distal to the coated surfaces of PMMA restorations.

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Antibacterial resin-based composite containing chlorhexidine for dental applications

Cited by 59 publications

References 44 publications

Resin based restorative dental materials: characteristics and future perspectives

Resin based restorative dental materials: characteristics and future perspectives

Physicochemical and Mechanical Properties of Bis-GMA/TEGDMA Dental Composite Resins Enriched with Quaternary Ammonium Polyethylenimine Nanoparticles

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

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