Antibacterial property of Ag nanoparticle-impregnated N-doped titania films under visible light

Wong, Ming‐Show; Chen, Chun-Wei; Hsieh, Chia‐Chun; Hung, S.; Sun, Der-Shan; Chang, Hsin-Hou

doi:10.1038/srep11978

Cited by 54 publications

(40 citation statements)

References 48 publications

(75 reference statements)

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“…A standard ELISA protocol was conducted5566 using a microplate reader as previously described676869. The circulating levels of sP-sel, IL-1β and TNF-α of experimental mice were determined by mouse sP-Selectin/CD62P, IL-1β and TNF-α ELISA kits (R&D Systems and BioLegend, San Diego, CA)5669; calculations were made by comparing the specific sP-sel, IL-1β and TNF-α values with standard curves of titrated P-sel, IL-1β and TNF-α, respectively.…”

Section: Methodsmentioning

confidence: 99%

Soluble P-selectin rescues viper venom–induced mortality through anti-inflammatory properties and PSGL-1 pathway-mediated correction of hemostasis

Sun

Chang

2016

Sci Rep

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Venomous snakebites are lethal and occur frequently worldwide each year, and receiving the antivenom antibody is currently the most effective treatment. However, the specific antivenom might be unavailable in remote areas. Snakebites by Viperidae usually lead to hemorrhage and mortality if untreated. In the present study, challenges of rattlesnake (Crotalus atrox) venom markedly increased the circulating soluble P-selectin (sP-sel) level, but not P-selectin (P-sel, Selp−/−) mutants, in wild-type mice. Because sP-sel enhances coagulation through the P-selectin ligand 1 (PSGL-1, Selplg) pathway to produce tissue factor–positive microparticles, we hypothesized that increasing the plasma sP-sel level can be a self-rescue response in hosts against snake venom–mediated suppression of the coagulation system. Confirming our hypothesis, our results indicated that compared with wild-type mice, Selp−/− and Selplg−/− mice were more sensitive to rattlesnake venom. Additionally, administration of recombinant sP-sel could effectively reduce the mortality rate of mice challenged with venoms from three other Viperidae snakes. The antivenom property of sP-sel is associated with improved coagulation activity in vivo. Our data suggest that the elevation of endogenous sP-sel level is a self-protective response against venom-suppressed coagulation. The administration of recombinant sP-sel may be developed as a new strategy to treat Viperidae snakebites.

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Section: Methodsmentioning

confidence: 99%

Soluble P-selectin rescues viper venom–induced mortality through anti-inflammatory properties and PSGL-1 pathway-mediated correction of hemostasis

Sun

Chang

2016

Sci Rep

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“…The basic principle involves causing irreversible damage in pathogenic cells by activating metal NPs or polymer-based systems using external energy sources, such as visible light [214], temperature [215], near-infrared (NIR) radiation [216], or high frequency alternating magnetic fields (AMF) [217]. Gold, iron oxide, and graphene NPs have been utilized as photothermal agents that absorb NIR light and convert this into heat energy.…”

Section: Nanotechnology Based Strategies For Biofilm Control and Tmentioning

confidence: 99%

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

Ramasamy

Lee

2016

BioMed Research International

204

126

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Bacterial colonization in the form of biofilms on surfaces causes persistent infections and is an issue of considerable concern to healthcare providers. There is an urgent need for novel antimicrobial or antibiofilm surfaces and biomedical devices that provide protection against biofilm formation and planktonic pathogens, including antibiotic resistant strains. In this context, recent developments in the material science and engineering fields and steady progress in the nanotechnology field have created opportunities to design new biomaterials and surfaces with anti-infective, antifouling, bactericidal, and antibiofilm properties. Here we review a number of the recently developed nanotechnology-based biomaterials and explain underlying strategies used to make antibiofilm surfaces.

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“…A concentration dependence was established for the bacterial deactivation with Ag content in TiO thin films with a quantity of 1, 3, 5 and 7 μg/ml Bahadur et al (2016). Wong et al (2015) reported increasing the visible-light response and durability of silver nanoparticles impregnated in TiO :(N) thin films against pathogens like E. coli, Streptococcus pyogenes, S. aureus and Acinetobacter baumanii.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of thin films TiO2 doped with Ag and Cu on Gracilicutes and Firmicutes bacteria

Stoyanova¹,

Ivanova²,

Angelov³

et al. 2017

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This article aims to explore the antibacterial activity of thin films of TiO doped with Ag and Cu using two types of Gram-negative and Gram-positive test bacteria with clinical significance (Gracilicutes and Firmcutes bacteria). The thin films (thickness of about 60 nm) were deposited on glass substrates by radio frequency magnetron co-sputtering (r.f. power of 50 W) of TiO target with Ag and Cu pieces on its surface in an Ar atmosphere (0.8 Pa) without heating during the deposition. The total surface area of the Ag was 60 mm and that of the Cu was 100 mm . Bacillus cereus, Staphylococcus epidermidis, Salmonella enterica, Escherichia coli and Pseudomonas sp. were used as test strains. The antibacterial actvity of the films was evaluated by the classical Koch's method and optical density measurements. The bactericidal effect was established at different time points between 30 min and 90 min for Pseudomonas sp. and S. enterica. The Firmicutes bacteria B. cereus and S. epidermidis were killed at the 4 and 8 hour of the treatment, respectively. The effect on E. coli was bacteriostatic until the 10 hour. The results were confirmed by assessment of the bacterial dehydrogenase activity. The studied thin films of TiO co-doped with Ag and Cu have a potential for application as antibacterial coatings.

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Antibacterial property of Ag nanoparticle-impregnated N-doped titania films under visible light

Cited by 54 publications

References 48 publications

Soluble P-selectin rescues viper venom–induced mortality through anti-inflammatory properties and PSGL-1 pathway-mediated correction of hemostasis

Soluble P-selectin rescues viper venom–induced mortality through anti-inflammatory properties and PSGL-1 pathway-mediated correction of hemostasis

Recent Nanotechnology Approaches for Prevention and Treatment of Biofilm-Associated Infections on Medical Devices

Antibacterial activity of thin films TiO2 doped with Ag and Cu on Gracilicutes and Firmicutes bacteria

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