Antibacterial properties of water-soluble gold(I) N-heterocyclic carbene complexes

In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates

“…Phosphanegold ( sulfanylcarboxylates [65], and carbenes [66] indicates further research investigating the antibacterial activity of gold compounds is warranted.…”

Recent Advances in Gold(I) Complexes Based Biological Applications

“…Water solubility has been considered of main interest in the development of both Au(I) NHC complexes as therapeutic agents [30]. Silbestri et al prepared a variety of water-soluble Au(I) NHC complexes and investigated their antibacterial properties [30].…”

“…Silbestri et al prepared a variety of water-soluble Au(I) NHC complexes and investigated their antibacterial properties [30]. The antibacterial results by agar diffusion and broth macrodilution methods evince the antimicrobial ability of these complexes against both Gram-and Gram+ bacterial strains.…”

N -Heterocyclic Carbene Metal Complexes as Bio-Organometallic Antimicrobial and Anticancer Drugs

“…ruckeri 500 - [134] 83 P. aeruginosa 500 - [134] 83 E. coli 500 11.20 ± 0.20 mm [134] 83 S. aureus 500 9.70 ± 2.50 mm [134] 83 E. faecalis 500 11.60 ± 0.60 mm [134] 83 M. luteus 500 25.60 ± 0.60 mm [134] 84 Y. ruckeri 500 12.0 ± 3.20 mm [134] 84 P. aeruginosa 500 8.25 ± 1.05 mm [134] 84 E. coli 500 8.65 ± 0.25 mm [134] 84 S. aureus 500 8.60 ± 1.40 mm [134] 84 E. faecalis 500 7.95 ± 0.75 mm [134] 84 M. luteus 500 14.75 ± 2.75 mm [134] 85 Y. ruckeri 500 - [134] 85 P. aeruginosa 500 7.50 ± 0.30 mm [134] 85 E. coli 500 - [134] 85 S. aureus 500 8.60 ± 0.40 mm [134] 85 E. faecalis 500 - [134] 85 M. luteus 500 11.73 ± 0.73 mm [134] 86 Y. ruckeri 500 - [134] 86 P. aeruginosa 500 - [134] 86 E. coli 500 - [134] 86 S. aureus 500 8.3 ± 1.1 mm [134] 86 E. faecalis 500 - [134] 86 M. luteus 500 8.55 ± 1.35 mm [134] Key term Apoptosis: Form of cell death in which a programmed sequence of events leads to the elimination of cells without the release of harmful substances into the surrounding area. though they have considerable structural differences, these two NHC-gold complexes demonstrated similarly effective anticancer activity toward A2780 human ovarian carcinoma cells.…”

“…In the near future, this finding would be definitely helpful in the clinical prospects of developing gold(I)-NHC complexes into useful anticancer metallopharmaceuticals. The anti- 97a R 1 = CH(CH 3 ) 2 , R 2 = H 97b R 1 = CH(CH 3 ) 2 , R 2 = CH 3 97c R 1 = CH(CH 3 ) 2 , R 2 = OCH 3 97d R 1 = CH(CH 3 ) 2 , R 2 = COOCH 3 97e R 1 = CH(CH 3 ) 2 , R 2 = CN 97f R 1 = H R 2 = H 97g R 1 = CH 3 R 2 = CH 3 97h R 1 = OCH 3 R 2 = CH 3 97i R 1 = Cl R 2 = OCH 3 (85) and (1,3-bis[2,6-diisopropyl-4-sodiumsulfonatophenyl] imidazol-2-ylidene)gold(I) chloride (86) was reported from Silbestri et al [134] (Figure 9). All the complexes were assessed by agar diffusion and broth macrodilution methods against Gram-positive S. aureus, E. faecalis and Micrococcus luteus and the Gram-negative bacteria Yersinia ruckeri, P. aeruginosa and E. coli.…”