Antibacterial properties of synthesized Ag and Ag@SiO<sub>2</sub> core–shell nanoparticles: a comparative study

Acharya, Debashish; Mohanta, Bidhan; Pandey, Piyush; Nasiri, Farnaj

doi:10.1139/cjp-2017-0614

Cited by 11 publications

(6 citation statements)

References 19 publications

(21 reference statements)

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“…However, most of the present therapeutic methods mainly focus on the bactericidal effect, so it is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Compared with previously reported Ag-based antibacterial core-shell NPs, bromfenac sodium were loaded into novel hollow core-shell nanoparticles could be given the anti-inflammatory ability of NPs 36 , 37 .…”

Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

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Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu 2 O-bromfenac sodium nanoparticles (AuAgCu 2 O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu 2 O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag + and Cu + ) by the hollow AuAgCu 2 O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu 2 O-BS NPs was verified both in vitro and in vivo . Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations.

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Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

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“…Acharya et al [ 90 ] demonstrated that Ag@SiO 2 core-shell nanoparticles (~17 nm) had a more substantial antibacterial effect on B. subtilis , S. aureus , Serratia marcescens, and K. pneumoniae than singular Ag NPs (~14 nm) due to controlled and sustainable release of Ag(I). Correspondingly, Gankhuyag et al [ 91 ] and Pal et al [ 92 ] recorded an enhanced bactericidal activity of SiO 2 @AgNPs and Ag-NP hybrid silica films against E. coli cells, respectively.…”

Section: Biological Studiesmentioning

confidence: 99%

Microwave Irradiation vs. Structural, Physicochemical, and Biological Features of Porous Environmentally Active Silver–Silica Nanocomposites

Strach

Dulski²,

Wasilkowski

et al. 2023

IJMS

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Heavy metals and other organic pollutants burden the environment, and their removal or neutralization is still inadequate. The great potential for development in this area includes porous, spherical silica nanostructures with a well-developed active surface and open porosity. In this context, we modified the surface of silica spheres using a microwave field (variable power and exposure time) to increase the metal uptake potential and build stable bioactive Ag2O/Ag2CO3 heterojunctions. The results showed that the power of the microwave field (P = 150 or 700 W) had a more negligible effect on carrier modification than time (t = 60 or 150 s). The surface-activated and silver-loaded silica carrier features like morphology, structure, and chemical composition correlate with microbial and antioxidant enzyme activity. We demonstrated that the increased sphericity of silver nanoparticles enormously increased toxicity against E. coli, B. cereus, and S. epidermidis. Furthermore, such structures negatively affected the antioxidant defense system of E. coli, B. cereus, and S. epidermidis through the induction of oxidative stress, leading to cell death. The most robust effects were found for nanocomposites in which the carrier was treated for an extended period in a microwave field.

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“…Various approaches can be used for filter production, with a common method involving the creation of silver/silica nanoparticle systems for coating air filters. Air filter media coated with AgNPs or AgNPs-coated SiO 2 spheres have shown a strong antiviral effect against bacteriophage MS2, without altering the filtration performances. , Haeng et al used AgNPs-coated nanosilica particles to coat air filters, providing effective virucidal action against MS2 viruses. To avoid the use of liquid in the coating process, studies on dry aerosol coatings have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antiviral Activities of Silver Nanocluster/Silica Composite Coatings Deposited onto Air Filters

Luceri,

Francese,

Perero

et al. 2024

ACS Appl. Mater. Interfaces

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The indoor air quality should be better controlled and improved to avoid numerous health issues. Even if different devices are developed for air filtration, the proliferation of microorganisms under certain conditions must be controlled. For this purpose, a silver nanocluster/silica composite coating was deposited via a cosputtering technique onto fiber glass and polymeric based substrates. The aim of this work is focused on the evaluation of the antibacterial and antiviral effects of the developed coating. The preliminary results of the compositional and morphological tests showed an evenly distributed coating on filters surfaces. Several antibacterial tests were performed, confirming strong effect both in qualitative and quantitative methods, against S. epidermidis and E. coli. To understand if the coating can stop the proliferation of bacteria colonies spread on it, simulation of everyday usage of filters was performed, nebulizing bacteria solution with high colonies concentration and evaluating the inhibition of bacteria growth. Additionally, a deep understanding of the virucidal action and mechanism of Ag nanoclusters of the coating was performed. The effect of the coating both in aqueous medium and in dry methods was evaluated, in comparison with analysis on ions release. The virucidal performances are assessed against the human coronavirus OC43 strain (HCoV-OC43).

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Antibacterial properties of synthesized Ag and Ag@SiO₂ core–shell nanoparticles: a comparative study

Cited by 11 publications

References 19 publications

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Microwave Irradiation vs. Structural, Physicochemical, and Biological Features of Porous Environmentally Active Silver–Silica Nanocomposites

Antibacterial and Antiviral Activities of Silver Nanocluster/Silica Composite Coatings Deposited onto Air Filters

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Antibacterial properties of synthesized Ag and Ag@SiO2 core–shell nanoparticles: a comparative study

Cited by 11 publications

References 19 publications

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Microwave Irradiation vs. Structural, Physicochemical, and Biological Features of Porous Environmentally Active Silver–Silica Nanocomposites

Antibacterial and Antiviral Activities of Silver Nanocluster/Silica Composite Coatings Deposited onto Air Filters

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Antibacterial properties of synthesized Ag and Ag@SiO₂ core–shell nanoparticles: a comparative study