Antibacterial Properties of PMMA Functionalized with CuFe2O4/Cu2O/CuO Nanoparticles

Abstract

We have prepared a composite thin coating by incorporation of CuFe2O4/Cu2O/CuO nanoparticles in polymethyl methacrylate (PMMA) matrix by using the solution casting method. The electrical explosion of two twisted wires (EETW) was used to obtain multicomponent CuFe2O4/Cu2O/CuO nanoparticles with an average particle size of 20–70 nm. The microscopic studies showed that the nanoparticles in the composite coatings are evenly distributed. However, nanoparticles are strongly agglomerated as the powder concentration in the coating increases to 5 wt.% and 10 wt.%, as the size of particle agglomerates increases to 50 and 100 μm, respectively. Therefore, nanoparticles were pre-treated with ultrasound when introduced into the PMMA matrix. The thermal stability of the composite coating does not change with the introduction of CuFe2O4/Cu2O/CuO nanoparticles in the amount of 5 wt.%. The inclusion of nanoparticles in the PMMA matrix significantly enhances its antibacterial activity. The addition of 5 wt.% nanoparticles inhibited the growth of E. coli by 100% and the growth of MRSA by 99.94% compared to pure PMMA already after 3 h of exposure of bacteria on the surface of the composites. This research provides an easy-to-manufacture and cost-efficient method for producing a CuFe2O4/Cu2O/CuO/PMMA composite coating with a broad application as an antibacterial material.

Functionalized ferrites for therapeutics and environmental pollution management

“…The inclusion of multicomponent CuFe 2 O 4 / Cu 2 O/CuO NPs in the polymethyl methacrylate (PMMA) matrix was carried out for enhanced antibacterial properties. The NPs-PMMA dispersion in acetone solution cast on a slide resulted in an antibiofilm nanocomposite [58]. Jay et al synthesized CH-functionalized nanostructured NiFe 2 O 4 (n-NiFe 2 O 4 -CH) thin film onto the indium tin oxide (ITO) glass substrate via this simple method [59].…”

New PMMA-Based Hydroxyapatite/ZnFe2O4/ZnO Composite with Antibacterial Performance and Low Toxicity

“…Figure 11 shows the effect of the synthesized samples on the viability of S. aureus, P. aeruginosa and MRSA bacterial strains, as well as C. albicans fungi. The antibacterial activity of the PMMA/NP composites was previously investigated by us in the article [39]. It was found that a mass fraction of nanoparticles in the composite of less than 5% weakly inhibited bacterial growth.…”

Investigating the biocompatibility, flexural strength, and surface roughness of denture base resin containing copper oxide nanoparticles: An in vitro study

“…Considering the abundant resources of Cu and its low cost in comparison to other particles such as Ag, CuO NPs can be used for their antibacterial, antifungal, and mechanical properties in prosthetic dentistry. Recent researchers revealed the antimicrobial effect of PMMA containing CuO NPs [ [22] , [23] , [24] ]. A recent study showed that adding CuFe2O4/Cu2O/CuO nanoparticles in the amount of 5 wt% can significantly enhance the antimicrobial effect of the resin [ 24 ].…”

“…Recent researchers revealed the antimicrobial effect of PMMA containing CuO NPs [ [22] , [23] , [24] ]. A recent study showed that adding CuFe2O4/Cu2O/CuO nanoparticles in the amount of 5 wt% can significantly enhance the antimicrobial effect of the resin [ 24 ].…”

“…However, the use of excessive CuO NPs is limited by their safety and toxicity [ [24] , [25] , [26] ]. The toxicity of NPs depends on different factors such as particle size, shape, concentration, coatings, cell type, and exposure condition and duration, which result in different situations that cannot be easily compared to each other [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ]. Moreover, NPs may penetrate through biological barriers due to their small sizes and reach the internal parts of the body, provoking hazardous cellular damage.…”