Antibacterial properties of modified biodegradable PHB non-woven fabric

Slepička, Petr; Malá, Zuzana; Rimpelová, Silvie; Švorčı́k, Václav

doi:10.1016/j.msec.2016.04.052

Cited by 51 publications

(31 citation statements)

References 13 publications

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“…The photographs of E. coli and S. epidermidis colony forming units on the samples: control sample, plasma modified sample with the power of 8 W and time 240 s (PHB 240 s/8 W), and then plasma modified sample consequently: (i) immersed to Au/PEG/H 2 O solution (PHB PM/AuPEG); (ii) immersed to Ag/PEG/H 2 O solution (PHB PM/AgPEG) or sputtered with silver of the effective thickness of 3 nm determined by gravimetry (PHB PM/Ag, 3 nm) [121]. …”

Section: Figurementioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.

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Section: Figurementioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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“…When immersing into Au solution, PHB inhibited the growth of S. epidermidis significantly. The implementation of Ag nanoparticles further improved the antibacterial efficiency of PHB for E. coli …”

Section: Preparation Of Antimicrobial Surfacementioning

confidence: 99%

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

Liu

Zhang

et al. 2017

Macro Materials & Eng

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Biomaterials for in vivo application should induce positive interaction with various histocytes and inhibit bacteria inflection as well. Cells and/or bacteria response to the extracellular environment is therefore the basic principle to design the biomaterials surface in order to induce the specific biomaterial–biological interaction. Polyhydroxyalkanoate (PHAs) are of growing interests because of their natural origin, biodegradability, biocompatibility, and thermoplasticity; however, quite inert and intrinsic hydrophobic characteristics have hindered their extensive usage in medical applications. Surface modification of PHAs tailors the chemistry, wettability, and topography without altering the bulk properties, and introduces specific proteins/peptides and/or antibacterial agents to mediate cell–matrix interactions. This review describes the recent developments on the surface modification of PHAs to construct cell compatible and antibacterial surfaces.

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“…Poly[( R )‐3‐hydroxybutyrate] (P3HB) belongs to the family of hydrophobic biodegradable polyesters also known as polyhydroxyalkanoates which can be biologically synthesized by different bacteria or extracted from genetically modified plants . This is a renewable and sustainable process compared to synthetic polymers which are derived from petroleum.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, P4HB is a hydrophobic resorbable polyester produced from bacteria that was approved by the United States Food and Drug Administration since 2007 and is used in a variety of medical applications such as sutures, hernia repair, plastic, and reconstructive surgery. P4HB is a biodegradable polyester which undergoes a bulk hydrolysis process to produce 4‐hydroxybutyrate (4HB) which is a natural constituent of the human body and can be found in the brain, heart, liver, lungs, muscles, and kidney . It is reported that the half‐life of 4HB is around 35 min and is thus metabolized quickly and removed from the body via the Krebs cycle .…”

Section: Introductionmentioning

confidence: 99%

New Poly[(R )-3-hydroxybutyrate-co -4-hydroxybutyrate] (P3HB4HB)-Based Thermogels

Wee

Liow

Liu

et al. 2017

Macromol. Chem. Phys.

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Poly[(R)‐3‐hydroxybutyrate] (P3HB) is a potential candidate for biomaterials due to its biocompatibility and biodegradability. However, P3HB needs to have tunable hydrophobicity, modification through chemical functionalization and the right hydrolytic stability to increase their potential for water‐based biomedical applications such as using them as in situ forming gels for drug delivery. This work focuses on using a copolymer, poly[(R)‐3‐hydroxybutyrate‐co‐4‐hydroxybutyrate] (P3HB4HB) in a thermogelling multiblock system with polypropylene glycol and polyethylene glycol to study the effect of the hydrophobic P3HB4HB on gelation properties, degradation, and drug release rates with reference to P3HB. Thermogels containing P3HB4HB segments show lower critical micellization concentration values in a range from 3 × 10−4 to 1.08 × 10−3 g mL−1 and lower critical gelation concentration values ranging from 2 to 6 wt% than that of gels containing P3HB. Furthermore, gels containing P3HB4HB degrade at a slower rate than the gels containing P3HB. Drug release studies of 5 µg mL−1 of doxorubicin show that gels containing P3HB4HB exhibit sustained release although the release rates are faster than gels containing P3HB. However, this can be modified by varying the concentration of the gels used. Process optimization of purifying the starting material is one important factor before the synthesis of these biomaterials.

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Antibacterial properties of modified biodegradable PHB non-woven fabric

Cited by 51 publications

References 13 publications

Surface Modification of Polymer Substrates for Biomedical Applications

Surface Modification of Polymer Substrates for Biomedical Applications

Surface Modification of Polyhydroxyalkanoates toward Enhancing Cell Compatibility and Antibacterial Activity

New Poly[(R )-3-hydroxybutyrate-co -4-hydroxybutyrate] (P3HB4HB)-Based Thermogels

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