Antibacterial properties of metal and metalloid ions in chronic periodontitis and peri-implantitis therapy

Goudouri, Ourania-Menti; Kontonasaki, Eleana; Lohbauer, Ulrich; Boccaccını, Aldo R.

doi:10.1016/j.actbio.2014.03.028

Cited by 93 publications

(70 citation statements)

References 224 publications

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“…10,11 Additionally, Zn ions show antibacterial effects, being therefore beneficial for the inhibition of infection. 12 Zinc-containing BG have shown enhanced calcified matrix deposition and ALP activity compared with BG without zinc. 13 Moreover, Zn-containing BG scaffolds were shown to exhibit antibacterial activity while retaining biocompatibility with human osteoblast-like cells (HOS).…”

Section: Introductionmentioning

confidence: 99%

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

et al. 2016

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a Zinc (Zn)-containing materials have osteogenic and antibacterial activities while bioactive glass nanoparticles (BGN) show bone-bonding ability, as well as osteoconductive and osteoinductive properties. Zn-containing BGN are therefore considered to be promising materials for various biomedical applications, particularly in bone regeneration. In this study, we report a convenient method to prepare Zn-containing BGN by coating ZnO quantum dots (QDs) on BGN via electrostatic interactions. The synthesized ZnO-BGN nanocomposite particles are spherical and highly dispersed, and exhibit a unique fluorescence behavior under UV excitation, emitting three wavelengths in the violet, blue and green range.ZnO-BGN showed apatite-forming ability upon immersion in simulated body fluid, but their apatite formation was delayed compared to BGN. Interestingly, ZnO-BGN showed a rapid release of Zn ions at pH 4 but a far slower release at pH 7.4. ZnO-BGN also exhibited antibacterial effects on both Gram-positive and Gram-negative bacteria at the concentrations of 1, 0.1, and 0.01 mg mL , but ZnO-BGN inhibited the relative proliferation of hMSC compared to BGN and the control according to the MTT assay. Notably ZnO-BGN improved the osteogenic differentiation of hMSC as indicated by the determination of the alkaline phosphatase activity. In conclusion, coating quantum dots on BGN is a promising strategy to produce Zn-containing BGN. The synthesized ZnO-BGN are potential materials for bone regeneration, considering their apatite-forming ability, unique ion-release behavior, effective antibacterial activity, non-cytotoxicity, and osteogenic potential.

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Section: Introductionmentioning

confidence: 99%

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

et al. 2016

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“…+ ions enter the bacterial cells either through ion channels or due to the detachment of the cytoplasm membrane [9,11].Onceinside,theycomplexwithnucleobasesofDNAand RNAleadingtoDNAcondensationandlossofreplicationability [6,9,12].…”

Section: Agmentioning

confidence: 99%

“…, Mg 2+ and Cl − depletion in serum [2][3][4].Hence,animprovementwastriedby combining AgNO 3 with a sulpha drug to obtain silver sulphadiazine [2]. Many other ionicAg drugs emerged,butAg-sulfadiazineremainedthemostwidelyused,althoughitdelaysthewound healing process [2,5].FurtherdevelopmentwenttosystemsforcontrolleddeliveryofAg + ions,Ag-containingwounddressings,cathetersandantibacterialcoatings [6,7]whichflooded the market recently [8].…”

Section: Silver (I) (Ag + )mentioning

confidence: 99%

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Inorganic Nanoparticles: Innovative Tools for Antimicrobial Agents

Kurtjak¹,

Aničić²,

Vukomanovicć³

2017

Antibacterial Agents

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Resistance of bacteria to antibiotics is an urgent problem of humanity, which leads to a lack of therapy for serious bacterial infections. Development of new antibiotics has almost ceased in the last decades-even when a new antibiotic is launched, very soon the resistance of bacteria appears. There is a long list of applications where antimicrobial protection is required to achieve effective treatment. However, if we use the same antibiotics for all these applications, we will remain caught in the "vicious circle" of constant discovery of new synthetic antibiotics and very fast development of their resistantspecies.Therefore,weneedtofindalternativestrategiesthatwillberoutinely usedforsomespecificconditions(wounds,implants,etc.).Thus,wewillkeeptheactivity ofantibioticsandsavethemforacuteconditions(pneumonia,meningitis,etc.).Anoption for designing alternative antimicrobial strategies is to go back to the antimicrobials that were used before the discovery of antibiotics, i.e., inorganic antimicrobial agents includ-

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“…The primary mechanisms behind the antibacterial activity are metal-ion effects and photo-catalysis. 36,37 The chemical structure of Ag bestows strong catalytic ability; in addition, Ag has a high reduction potential, thus it can produce atomic oxygen in its surrounding environment. Atomic oxygen is a strong oxidizing agent, which is ideal for sterilization purposes.…”

mentioning

confidence: 99%

Accelerated fabrication of antibacterial and osteoinductive electrospun fibrous scaffolds via electrochemical deposition

Wang

Gao

et al. 2018

RSC Adv.

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Electrospun fibrous scaffolds have attracted much research interest due to their many applications in orthopedics and other relevant fields. However, poor surface bioactivity of the polymer scaffold body significantly limits the implementation of many potential applications, and an effective solution remains a great challenge for researchers. Herein, a highly efficient method, namely pulsed electrochemical deposition (ED) with co-electrospinning nano-Ag dopant, to fabricate poly(L-lactic acid) (PLLA)/nano-Ag composite fibers is presented. The resulting product demonstrated excellent antibacterial properties, as well as strong capabilities in facilitating the precipitation of calcium phosphate crystals at fiber surfaces and in promoting osteogenic differentiation. In the process of ED, the conductivity of the fibers was observed to increase due to the nano-Ag dopant. Upon applying pulse signals when charging, water electrolysis occurred in micro-reactive regions of anodic fibers, forming OH À , an alkaline environment that allowed the supersaturation of calcium phosphate. When discharging, the calcium phosphate in the solution diffused rapidly and reduced the concentration polarization, reforming a homogeneous electrolyte. The realization of efficient bioactive coatings at fiber surfaces was achieved in a highly efficient manner by repeating the above charging and discharging processes. Therefore, ED can be adopted to simplify and accelerate the fabrication process of an osteogenetic and antibacterial electrospun fibrous scaffold.

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Antibacterial properties of metal and metalloid ions in chronic periodontitis and peri-implantitis therapy

Cited by 93 publications

References 224 publications

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

ZnO quantum dots modified bioactive glass nanoparticles with pH-sensitive release of Zn ions, fluorescence, antibacterial and osteogenic properties

Inorganic Nanoparticles: Innovative Tools for Antimicrobial Agents

Accelerated fabrication of antibacterial and osteoinductive electrospun fibrous scaffolds via electrochemical deposition

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