Antibacterial properties of an acrylic resin containing curcumin nanoparticles: An in vitro study

Khamooshi, Pegah; Pourhajibagher, Maryam; Ahmad, Shahzad; Bahador, Abbas; Ahmadi, Badreddin; Arab, Sepideh

doi:10.34172/joddd.2022.032

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…According to their results, none of the curcumin nanoparticle concentrations showed growth inhibition zones for any microorganisms. However, all the concentrations were effective against all four microorganisms in the biofilm inhibition test except 0.5% for L. acidophilus [37].…”

Section: Antimicrobial Resultsmentioning

confidence: 94%

Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

Soleymanijadidi,

Moradi,

Hamedirad

et al. 2023

Bioengineering

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The placement of orthodontic appliances into the oral area can lead to infection, inflammatory and gingival collapse. Using an antimicrobial and anti-inflammatory material in the matrix of orthodontic appliance may help to reduce these issues. This study aimed to assess the release pattern, the antimicrobial action and the flexural strength of self-cured acrylic resins after adding different weight percentages of curcumin nanoparticles (nanocurcumin). In this in-vitro study, 60 acrylic resin samples were divided into five groups (n = 12) based on the weight percentage of curcumin nanoparticles added to the acrylic powder (0 for control, 0.5, 1, 2.5, and 5%). Then, the dissolution apparatus was used for the release assessment of nanocurcumin form the resins. For antimicrobial action assessment, the disk diffusion method was used and a three-point bending test was performed with a speed of 5 mm/min to determine the flexural strength. Data were analyzed using one-way analysis of variance (ANOVA) and Post-Hoc Tukey tests (with p < 0.05 as significant level). The microscopic images showed the homogeny distribution of nanocuricumin in self-cured acrylic resins in varied concentrations. The release pattern showed a two-step release pattern for all concentrations of nanocurcumin. The one-way ANOVA outcomes indicated that adding curcumin nanoparticles to self-cured resin increased the diameter of the inhibition zones for the groups against Streptococcus mutans (S. mutans) significantly (p < 0.0001). Additionally, as the weight percentage of curcumin nanoparticles increased, the flexural strength decreased (p < 0.0001). However, all strength values were higher than the standard value (50 MPa). No significant difference was detected between the control group and the group with 0.5 percent (p = 0.57). Considering the proper release pattern and the potent antimicrobial activity of curcumin nanoparticles, then the preparing self-cured resins containing curcumin nanoparticles can be beneficial for antimicrobial aims without damaging the flexural strength to use in orthodontic removable applications.

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Section: Antimicrobial Resultsmentioning

confidence: 94%

Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

Soleymanijadidi,

Moradi,

Hamedirad

et al. 2023

Bioengineering

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“…Curcumin has been successfully added into acrylic resin in different concentrations as an anti-fungal agent against Candida albicans in many studies. 11,14 Although these studies proved the biological efficacy, addition of any agent in the acrylic resin may bring change in the mechanical properties due to which its use for intraoral function may not be acceptable. As there are limited studies regarding the strength of acrylic resin with curcumin incorporated as an anti-fungal additive, this study was done to evaluate the flexural strength of acrylic resin incorporated with different curcumin concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Among the organic products, a study showed that incorporating 0.5%, 1% and 2% Curcumin into acrylic resin was effective against the Candida albicans, reducing their growth. 11 A denture in an intraoral environment is subjected to a variety of forces during use, which can result in flexural and impact stresses which causes it to break because acrylic resin has less flexural strength. 12 Moreover, any additive to the acrylic resin may impact the mechanical properties reducing their flexural strength.…”

Section: Introductionmentioning

confidence: 99%

Flexural Strength of Heat Cure Denture Base Resin incorporated with Curcumin: An In-Vitro Study

Khanal,

Shrestha,

Joshi

et al. 2023

J. Nep. Prosthodon. Soc.

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Introduction: Acrylic resin when used for fabrication of denture is susceptible for microbial colonization. Many antimicrobial agents have proven effective against the microbial colonization when they were incorporated into the acrylic resin but adding anything into the acrylic resin can alter its mechanical properties resulting into unacceptable intraoral use. This study was done to evaluate ifadding an antimicrobial agent, Curcumin, alters the flexural strength of acrylic agent. Methods: 172 acrylic strips were fabricated. They were divided equally into 4 groups depending upon concentration of curcumin as Control, T1: 1% curcumin, T2: 3% curcumin and T4: 5% curcumin. Flexural strength was tested using 3-point bend test using Universal Testing Machine. Results: There was no significant difference in values of mean flexural strength for control, 1% and 3% curcumin groups. There was significant difference in the mean value between control and 5% curcumin group. Conclusion: 1% and 3% curcumin can be incorporated into acrylic resin without significantly altering its mechanical properties.

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Antibacterial properties of an acrylic resin containing curcumin nanoparticles: An in vitro study

Cited by 2 publications

References 26 publications

Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

Nanocurcumin Release from Self-Cured Acrylic Resins; Effects on Antimicrobial Action and Flexural Strength

Flexural Strength of Heat Cure Denture Base Resin incorporated with Curcumin: An In-Vitro Study

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