Antibacterial, pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing

Rivera, Laura Ramos; Cochis, Andrea; Biser, Sarah; Canciani, Elena; Ferraris, Sara; Rimondini, Lia; Boccaccını, Aldo R.

doi:10.1016/j.bioactmat.2020.11.001

Cited by 65 publications

(40 citation statements)

References 50 publications

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“…Pure copper except for good conductive and thermally conductive properties, also have antibacterial and catalytic effects [134,135]. In the study of Wang et al [136], alternately deposited nickel-copper coatings were produced to provide both excellent wear resistance and antimicrobial properties.…”

Section: Prospect and Challenge Of 3d Printing In Pure Coppermentioning

confidence: 99%

A Review on Additive Manufacturing of Pure Copper

Jiang

Zhang

et al. 2021

Coatings

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With the development of the aerospace and automotive industries, high heat exchange efficiency is a challenge facing the development of various industries. Pure copper has excellent mechanical and physical properties, especially high thermal conductivity and electrical conductivity. These excellent properties make pure copper the material of choice for the manufacture of heat exchangers and other electrical components. However, the traditional processing method is difficult to achieve the production of pure copper complex parts, so the production of pure copper parts through additive manufacturing has become a problem that must be overcome in industrial development. In this article, we not only reviewed the current status of research on the structural design and preparation of complex pure copper parts by researchers using selective laser melting (SLM), selective electron beam melting (SEBM) and binder jetting (BJ) in recent years, but also reviewed the forming, physical properties and mechanical aspects of pure copper parts prepared by different additive manufacturing methods. Finally, the development trend of additive manufacturing of pure copper parts is also prospected.

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Section: Prospect and Challenge Of 3d Printing In Pure Coppermentioning

confidence: 99%

A Review on Additive Manufacturing of Pure Copper

Jiang

Zhang

et al. 2021

Coatings

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“…Cu-MBGN are primarily synthesized for biomedical applications, particularly osteogenic regeneration [ 24 ]. Application of Cu-MBGN caused a reduction in bacterial viability of Staphylococcus aureus , Escherichia coli , and Staphylococcus epidermidis [ 19 , 27 , 28 ] as well as hydroxyapatite formation upon exposure to simulated body fluid [ 19 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Copper-Doped Mesoporous Bioactive Glass Nanospheres in Experimental Dental Composites: Chemical and Mechanical Characterization

et al. 2021

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Experimental dental resin composites incorporating copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were designed to impart antibacterial and remineralizing properties. The study evaluated the influence of Cu-MBGN on the mechanical properties and photopolymerization of resin composites. Cu-MBGN were synthesized using a microemulsion-assisted sol–gel method. Increasing amounts of Cu-MBGN (0, 1, 5, and 10 wt %) were added to the organic polymer matrix with inert glass micro- and nanofillers while maintaining a constant resin/filler ratio. Six tests were performed: X-ray diffraction, scanning electron microscopy, flexural strength (FS), flexural modulus (FM), Vickers microhardness (MH), and degree of conversion (DC). FS and MH of Cu-MBGN composites with silica fillers showed no deterioration with aging, with statistically similar results at 1 and 28 days. FM was not influenced by the addition of Cu-MBGN but was reduced for all tested materials after 28 days. The specimens with 1 and 5% Cu-MBGN had the highest FS, FM, MH, and DC values at 28 days, while controls with 45S5 bioactive glass had the lowest FM, FS, and MH. DC was high for all materials (83.7–93.0%). Cu-MBGN composites with silica have a potential for clinical implementation due to high DC and good mechanical properties with adequate resistance to aging.

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“…As such, no harmful content of Cu was assessed as of 2 wt.pct in a coating [ 46 ]. Moreover, there are several reports of introducing antibacterial properties together with increasing bioactivity and biocompatibility for Cu-incorporated HAp [ 51 ], Cu-doped polymer–ceramic coating [ 52 ], and Cu-implemented anodic coatings [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy

et al. 2021

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Titanium implants are commonly used because of several advantages, but their surface modification is necessary to enhance bioactivity. Recently, their surface coatings were developed to induce local antibacterial properties. The aim of this research was to investigate and compare mechanical properties of three coatings: multi-wall carbon nanotubes (MWCNTs), bi-layer composed of an inner MWCNTs layer and an outer TiO2 layer, and dispersion coatings comprised of simultaneously deposited MWCNTs and nanoCu, each electrophoretically deposited on the Ti13Nb13Zr alloy. Optical microscopy, scanning electron microscopy, X-ray electron diffraction spectroscopy, and nanoindentation technique were applied to study topography, chemical composition, hardness, plastic and elastic properties. The results demonstrate that the addition of nanocopper or titanium dioxide to MWCNTs coating increases hardness, lowers Young’s modulus, improves plastic and elastic properties, wear resistance under deflection, and plastic deformation resistance. The results can be attributed to different properties, structure and geometry of applied particles, various deposition techniques, and the possible appearance of porous structures. These innovative coatings of simultaneously high strength and elasticity are promising to apply for deposition on long-term titanium implants.

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Antibacterial, pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing

Cited by 65 publications

References 50 publications

A Review on Additive Manufacturing of Pure Copper

A Review on Additive Manufacturing of Pure Copper

Incorporation of Copper-Doped Mesoporous Bioactive Glass Nanospheres in Experimental Dental Composites: Chemical and Mechanical Characterization

Mechanical Behavior of Bi-Layer and Dispersion Coatings Composed of Several Nanostructures on Ti13Nb13Zr Alloy

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