Antibacterial potentials of pillar[5]arene, pillar[4]arene[1]quinone derivative and their isatin inclusion complexes

JothiNayaki, Sekar; Ravindhiran, Ramya; Srividhya, Sankar; Kiruthika, Jeyavelraman; Krishnamurthy, Ramya; Sivarajan, Karthiga; Arunachalam, M.; Dhandapani, Kavitha

doi:10.1080/10610278.2023.2173072

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…This tunability makes them versatile tools for targeted biofilm mitigation strategies. Pillar[ n ]arene-based inclusion complexes can also serve as drug delivery systems for antimicrobial agents . The controlled release of drugs from the complexes, facilitated by noncovalent interactions, allows for sustained and targeted delivery to biofilm-associated microorganisms.…”

Section: Pillar[n]arene-based Anti-biofilm Agentsmentioning

confidence: 99%

“…48−55 Pillar[n]arenes have been shown to possess inherent antimicrobial properties against a broad range of planktonic bacteria, including both Gram-positive and Gram-negative strains. 51,56 Biocompatibility and safety are the essential aspects of any potential antibiofilm agents for human use. Preliminary investigations suggest pillar[n]arenes and their derivatives as safe and biocompatible agents; hence they exhibit low cytotoxicity and minimal adverse effects.…”

Section: ■ Introductionmentioning

confidence: 99%

“…(2) Pillar[ n ]arene-based inclusion complexes to mitigate biofilms: The second section of this review highlights materials fabricated by forming inclusion complexes with antibiotics and other antibacterial drugs. The intrinsic hydrophobic cavities of pillar[ n ]arenes can encapsulate antibiotics and other antibacterial agents inside their cavities, ,,− which improves the stability and controlled release of these therapeutic agents, leading to more effective antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, one such promising avenue has been the use of pillar[ n ]arenes as anti-biofilm agents. Pillar[ n ]arenes, a class of macrocyclic host molecules with a distinctive pillar-shaped architecture, exhibit remarkable host–guest interactions, enabling them to complex with a diverse range of guest molecules. − Their significant properties stem from their unique structural features, rendering them promising candidates for various applications in supramolecular chemistry. − Modifiable functionalities and unique structural characteristics of pillar[ n ]arenes hold promise for developing materials specifically tailored for biological applications. − Pillar[ n ]arenes have been shown to possess inherent antimicrobial properties against a broad range of planktonic bacteria, including both Gram-positive and Gram-negative strains. , Biocompatibility and safety are the essential aspects of any potential anti-biofilm agents for human use. Preliminary investigations suggest pillar[ n ]arenes and their derivatives as safe and biocompatible agents; hence they exhibit low cytotoxicity and minimal adverse effects. − The unique properties of pillar[ n ]arenes extend beyond their antimicrobial potential, encompassing artificial transmembrane transport capabilities. − Pillar[ n ]arene derivatives possess the capacity to facilitate the transport of specific molecules across cell membranes.…”

Section: Introductionmentioning

confidence: 99%

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Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

Jothi Nayaki,

Roja,

Ravindhiran

et al. 2024

ACS Infect. Dis.

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The global surge in bacterial infections, compounded by the alarming escalation of drug-resistant strains, has evolved into a critical public health crisis. Among the challenges posed, biofilms stand out due to their formidable resistance to conventional antibiotics. This review delves into the burgeoning potential of pillar[n]arenes, distinctive macrocyclic host molecules, as promising anti-biofilm agents. The review is structured into two main sections, each dedicated to exploring distinct facets of pillar[n]arene applications. The first section scrutinizes functionalized pillar[n]arenes with a particular emphasis on cationic derivatives. This analysis reveals their significant efficacy in inhibiting biofilm formation, underscoring the pivotal role of specific chemical attributes in combating microbial communities. The second section of the review shifts its focus to inclusion complexes, elucidating how pillar[n]arenes serve as encapsulation platforms for antibiotics. This encapsulation enhances the stability of antibiotics and enables a controlled release, thereby amplifying their antibacterial activity. The examination of inclusion complexes provides valuable insights into the potential synergy between pillar[n]arenes and traditional antibiotics, offering a novel avenue for overcoming biofilm resistance. This comprehensive review highlights the escalating global threat of bacterial infections and the urgent need for innovative strategies to counteract drugresistant biofilms. The unique properties of pillar[n]arenes, both as functionalized molecules and as inclusion complex hosts, position them as promising candidates in the quest for effective anti-biofilm agents. The exploration of their distinct mechanisms opens new avenues for research and development in the ongoing battle against bacterial infections and biofilm-related health challenges.

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Section: Pillar[n]arene-based Anti-biofilm Agentsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

Jothi Nayaki,

Roja,

Ravindhiran

et al. 2024

ACS Infect. Dis.

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Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals

Bugalia,

Dhayal,

Sachdeva

et al. 2023

J Inorg Organomet Polym

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Role of synthetic coordination chemistry in pharmaceutical science is expeditiously increased due to its sundry relevances in this field. The present review endows the synthesized macrocyclic complexes of transition metal ions containing isatin and its derivatives as ligand precursors, their characterization and their copious pharmaceutical applications. Isatin (1 H -Indole-2,3-dione) is a protean compound (presence of lactam and keto moiety permits to change its molecular framework) that can be obtained from marine animals, plants, and is also found in mammalian tissues and in human fluids as a metabolite of amino acids. It can be used for the synthesis of miscellaneous organic and inorganic complexes and for designing of drugs since it has remarkable utility in pharmaceutical industry due to its wide range of biological and pharmacological activities, for instance anti-microbial, anti-HIV, anti-tubercular, anti-cancer, anti-viral, anti-oxidant, anti-inflammatory, anti-angiogenic, analgesic activity, anti-Parkinson’s disease, anti-convulsant etc. This review provides extensive information about the latest methods for the synthesis of isatin or its substituted derivatives based macrocyclic complexes of transition metals and their plentiful applications in medicinal chemistry. Graphical Abstract

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Bletilla Striata polysaccharides thermosensitive gel for photothermal treatment of bacterial infection

Zeng,

Qian,

Wang

et al. 2023

International Journal of Biological Macromolecules

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Antibacterial potentials of pillar[5]arene, pillar[4]arene[1]quinone derivative and their isatin inclusion complexes

Cited by 4 publications

References 34 publications

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

Pillar[n]arenes in the Fight against Biofilms: Current Developments and Future Perspectives

Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals

Bletilla Striata polysaccharides thermosensitive gel for photothermal treatment of bacterial infection

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