Antibacterial Potential of Northeastern Portugal Wild Plant Extracts and Respective Phenolic Compounds

Abstract

The present work aims to assess the antibacterial potential of phenolic extracts, recovered from plants obtained on the North East of Portugal, and of their phenolic compounds (ellagic, caffeic, and gallic acids, quercetin, kaempferol, and rutin), against bacteria commonly found on skin infections. The disk diffusion and the susceptibility assays were used to identify the most active extracts and phenolic compounds. The effect of selected phenolic compounds on animal cells was assessed by determination of cellular metabolic activity. Gallic acid had a higher activity, against gram-positive (S. epidermidis and S. aureus) and gram-negative bacteria (K. pneumoniae) at lower concentrations, than the other compounds. The caffeic acid, also, showed good antibacterial activity against the 3 bacteria used. The gallic acid was effective against the 3 bacteria without causing harm to the animal cells. Gallic and caffeic acid showed a promising applicability as antibacterial agents for the treatment of infected wounds.

Caffeic Acid Loading Wound Dressing: Physicochemical and Biological Characterization

“…This method has been often use for in vitro cytotoxicity evaluation of polymeric materials, and correlates the mitochondrial status with cell proliferation [2]. The caffeic acid effect on 3T3 fibroblasts was Caffeic acid loading wound dressing: physicochemical & biological characterization Research Article described as dose-dependent, being safe for concentrations under 7mM [32]. Gel-HPβ allows only 40% of the cells to survive as a reflection of its higher ability to deliver caffeic acid (120 mM after 48 h).…”

The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans

“…Kaempferol (KAE), one of the active flavonoids, widely exists in many fruits and plants with broad-spectrum antioxidant, anti-inflammatory and anticancer properties (Rajendran et al 2014). As demonstrated previously, KAE and its derivatives (especially kaempferol rhamnoside) have been considered to possess satisfactory antibacterial and antifungal capabilities (Kataoka et al 2001;Tatsimo et al 2012;Martino et al 2014;Pinho et al 2014). Recently, KAE was reported to present synergistic antifungal activities with histone deacetylase (HDAC) inhibitor against C. tropicalis in spite of its mild activity against C. albicans (Rajasekharan et al 2014).…”

Cotton‐hydrogel composite for improved wound healing: Antimicrobial activity and anti‐inflammatory evaluation—Part 2

“…The presence of microorganism on the wound bed may delay the healing process, giving rise to chronic wounds. Gallic acid is a simple phenolic acid with good applicability as antibacterial agent against bacteria, commonly isolated from infected wounds . It was, already used, with success to add antimicrobial properties to hydrogels networks .…”