Antibacterial Potential of Microwave-Assisted Extraction Prepared Hydrolates from Different Salvia Species

Űrgeová, Eva; Uvackova, Lubica; Vaneková, Miroslava; Maliar, Tibor

doi:10.3390/plants12061325

Cited by 5 publications

(4 citation statements)

References 50 publications

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“…Regarding the comparison of data from the literature on the antioxidant activity researched by DPPH and ABTS tests of the same plant species and their hydrolates obtained by steam distillation as in our study, SM (Serbia), LO (Bulgaria, France), MO (Bulgaria), MP (Bulgaria), RO (France), SS (Slovak Republic), and LI and OV (Romania) hydrolates [38,56,63,65] are in the range of agreement with our results (Table 2). However, TV could not be appropriately compared with other TV hydrolates due to the different formats used in the studies [62,66,67] except for the excellent data agreement present for TV hydrolates from Romania [56].…”

Section: Antioxidative Properties Total Phenolics and Reducing Sugar ...mentioning

confidence: 95%

Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts

Smiljanić,

Prodić,

Trifunovic

et al. 2023

Antioxidants

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As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we have tested nine hydrolates from the Lamiaceae family with skin fibroblasts that are responsible for extracellular collagenous matrix builds. Thyme, oregano, and winter savoury hydrolates showed several times higher total phenolics, which correlated strongly with their radical scavenging and antioxidative capacity; there was no correlation between their viability profiles and the reducing sugar levels. No proteins/peptides were detected. All hydrolates appeared safe for prolonged skin exposure except for 10-fold diluted lavender, which showed cytotoxicity (~20%), as well as rosemary and lavandin (~10%) using viability, DNA synthesis, and cell count testing. Clary sage, oregano, lemon balm, and thyme hydrolates (10-fold diluted) increased fibroblast viability and/or proliferation by 10–30% compared with the control, while their viability remained unaffected by Mentha and winter savoury. In line with the STITCH database, increased viability could be attributed to thymol presence in oregano and thyme hydrolates in lemon balm, which is most likely attributable to neral and geranial. The proliferative effect of clary sage could be supported by alpha-terpineol, not linalool. The major volatile organic compounds (VOCs) associated with cytotoxic effects on fibroblasts were borneol, 1,8-cineole, and terpinene-4-ol. Further research with pure compounds is warranted to confirm the roles of VOCs in the observed effects that are relevant to cosmetic and wound healing aspects.

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Section: Antioxidative Properties Total Phenolics and Reducing Sugar ...mentioning

confidence: 95%

Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts

Smiljanić,

Prodić,

Trifunovic

et al. 2023

Antioxidants

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“…Furthermore, C. hystrix EO, has demonstrated inhibitory effect against various bacteria such as Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, and Proteus vulgaris [38]. The observed inhibitory effects of Citrus EOs against these bacteria are attributed to specific volatile components such as Dlimonene and isopulegol, which are believed to contribute significantly to their antimicrobial properties [39,40].…”

Section: Discussionmentioning

confidence: 99%

Chemometric Analysis of GC-MS Chemical Profiles and Biological Activities of Three Citrus Essential Oils in Indonesia

Nuryandani,

Novitasari,

Abdurrahman

et al. 2024

Preprint

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Citrus species essential oils (EOs) are significant sources of bioactive compounds and demonstrate diverse therapeutic effects. However, limited documentation exists regarding the phytochemicals associated with their biological activities. This study aims to assess the antioxidant activity, plant inhibitory properties, and brine shrimp cytotoxic effects of EOs derived from three Citrus species: C. sinensis, C. limon, and C. hystrix. Utilizing chemometric analysis and gas chromatography-mass spectrometry (GC-MS) fingerprints, the volatile components contributing to antioxidant activity were elucidated. The peels of the Citrus samples were hydro-distillated to obtain EOs, and subsequently subjected to antioxidant, plant inhibitory, and brine shrimp cytotoxic assays. The results indicated that C. limon EO exhibited the highest antioxidant activity, while C. hystrix and C. sinensis EOs demonstrated pronounced inhibitory effects against Aetrmia salina and Lactuca sativa, respectively. GC-MS analysis facilitated the identification of key compounds in each EO. Principal component analysis (PCA) and hierarchy cluster analysis (HCA) effectively categorized Citrus EOs based on their antioxidant properties, highlighting the proximity of C. limon and C. sinensis. Among the identified compounds, D-limonene, α-Terpineol, Caryophyllene, (+)-3-Carene, β-Pinene, (-)-Spathulenol, trans-p-Mentha-1(7),8-dien-2-ol, and trans-Verbenol were the most discriminating compounds affected the antioxidant activity of C.limon and C. sinensis EOs.

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“…Studies showed that Salvia sp. plants contain numerous flavonoids like apigenin 7-glucoside, 8-di-C-glucosyl apigenin, luteolin 7-glucoside, luteolin 7-diglucoside, and phenolic acids, which possess antioxidant and anti-inflammatory activities [171].…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

Zhumaliyeva,

Zhussupova,

Zhusupova

et al. 2023

Biomedicines

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The study of medicinal plants is important, as they are the natural reserve of potent biologically active compounds. With wide use in traditional medicine and the inclusion of several species (as parts and as a whole plant) in pharmacopeia, species from the genus Salvia L. are known for the broad spectrum of their biological activities. Studies suggest that these plants possess antioxidant, anti-inflammatory, antinociceptive, anticancer, antimicrobial, antidiabetic, antiangiogenic, hepatoprotective, cognitive and memory-enhancing effects. Phenolic acids, terpenoids and flavonoids are important phytochemicals, which are primarily responsible for the medicinal activity of Salvia L. This review collects and summarizes currently available data on the pharmacological properties of sage, outlining its principal physiologically active components, and it explores the molecular mechanism of their biological activity. Particular attention was given to the species commonly found in Kazakhstan, especially to Salvia trautvetteri Regel, which is native to this country.

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Antibacterial Potential of Microwave-Assisted Extraction Prepared Hydrolates from Different Salvia Species

Cited by 5 publications

References 50 publications

Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts

Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts

Chemometric Analysis of GC-MS Chemical Profiles and Biological Activities of Three Citrus Essential Oils in Indonesia

Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity

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