Antibacterial PLA Fibers Containing Thiazolium Groups as Wound Dressing Materials

Echeverría, Coro; Muñoz‐Bonilla, Alexandra; Cuervo-Rodríguez, Rocío; López, Daniel; Fernández‐García, Marta

doi:10.1021/acsabm.9b00923

Cited by 27 publications

(27 citation statements)

References 28 publications

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“…To do so, we process PLA through electrospinning coupled to a rotatory drum collector, capable of forming polymer fibers with diameters ranging from micrometer to nanometer scales with high surface-to-volume ratio, flexibility, tunable porosity [ 26 , 27 ] and, moreover, able to induce fiber alignment [ 28 , 29 ]. The resultant fibers can be used in a variety of applications, ranging from sensors, drug-delivery systems, tissue regeneration, among others [ 30 , 31 , 32 , 33 , 34 , 35 ]. In the case of PLA, certain electrospinning conditions and set-ups, such as the coupling of rotatory cylinder (drum) as fiber collector, contribute to the stretching of the polymer while collecting the fibers in the drum.…”

Section: Introductionmentioning

confidence: 99%

Development of Highly Crystalline Polylactic Acid with β-Crystalline Phase from the Induced Alignment of Electrospun Fibers

et al. 2021

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Polylactic acid (PLA) is one of the known synthetic polymers with potential piezoelectric activity but this property is directly related to both the crystalline structure and crystalline degree. Depending on the process conditions, PLA can crystallize in three different forms: α-, β-, and γ- form, with β-crystalline phase being the piezoelectric one. To obtain this crystalline structure, transformation of α to β is required. To do so, the strategies followed so far consisted in annealing or/and stretching of previously obtained PLA in the form of films or fibers, that is, additional post-processing steps. In this work, we are able to obtain PLA fibers with high macromolecular alignment, as demonstrated by SEM, and in the β polymorph, as detected by X-ray diffraction (XRD) without the requirement of post-processing. For that, PLA fibers were prepared by using an electrospinning coupled to a drum collector. This set up and the optimization of the parameters (voltage flow-rate, and drum collector speed) induced molecular stretching giving rise to uniaxially oriented and highly aligned fibers.

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Section: Introductionmentioning

confidence: 99%

Development of Highly Crystalline Polylactic Acid with β-Crystalline Phase from the Induced Alignment of Electrospun Fibers

et al. 2021

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“…A variety of polymers has been prepared including homopolymers, statistical and block copolymers synthesized by conventional or controlled radical polymerization [28][29][30][31][32]. Then, some statistical and block copolymers have been also used as additives in polymer blends to obtain films, coatings or fibers [33][34][35][36]. However, their structuration as hydrogels has not been yet tested.…”

Section: Introductionmentioning

confidence: 99%

Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior

et al. 2020

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Several hydrogels based on 2-hydroxyethyl methacrylate and a methacrylic monomer containing a thiazole group in its lateral chain have been prepared by thermal polymerization at 60 °C in water solution varying the chemical composition of the gels. The posterior quaternization of the thiazole groups with methyl iodine has rendered positively charged hydrogels with potential antimicrobial activity. This modification has been structurally characterized by infrared spectroscopy, whereas the thermal stability of all hydrogels has been studied by thermal degradation in inert atmosphere. The swelling behavior in distilled water and the rheology of the different hydrogels have been analyzed as a function of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) monomer content as well as its methylation. Finally, the active character of hydrogels against Gram-positive and Gram-negative bacteria and fungi has been evaluated, revealing excellent antimicrobial activity against all tested microorganisms. The methylated hydrogels could be used as potential materials for wound healing or contact lens applications.

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“…One of the main disadvantages of the electrospinning for the industrial sector is its low productivity 146 . Electrospun PLA fibers were reported as medical devices, 147–149,151 agricultural films, 146 nanofibrous membrane for filtration, 150 etc.…”

Section: Methods For Pla Processingmentioning

confidence: 99%

“…Modification of a PLA matrix to prevent growth or reduce adhesion of microorganisms is a highly desired objective 151 . For the preparation of PLA material that exhibits antioxidant, antimicrobial, or wound healing activity addition of TiO 2 , sodium metabisulfite (NaM), collagen, essential oils, and thymol to PLA was reported 5,6,11,109,117,169,177 .…”

Section: Effect Of Process Variables On Pla‐based Materialsmentioning

confidence: 99%

Tailoring of advanced poly(lactic acid)‐based materials: A review

Milovanović

Pajnik

Lukić

2021

J of Applied Polymer Sci

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Poly(lactic acid) (PLA) stands out as the most promising biodegradable alternative to conventional petrochemical‐based polymers for manufacturing of high‐performance materials applied in medicine, pharmacy, food, textile, and electronic industry. This review was aimed to present the conventional and up‐to‐date technologies for PLA processing including melt blending and molding, hot melt extrusion, 3D printing, foaming, impregnation, thermally induced phase separation, nano‐ and microparticles preparation, wet and dry spinning processes. In addition, the effect of the processing parameters and polymer characteristics on the properties of the final material was elaborated. Diverse possibilities to tailor properties of PLA‐based materials by variation in polymer characteristics and concentration, solvent selection, drying method, processing pressure and temperature, incorporation of bioactive components, and so on were highlighted. The examples of the relations between processing methods, parameters, and end‐product properties are given for a better understanding of all aspects that need to be perceived for fabrication of PLA‐based materials with required performances.

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Antibacterial PLA Fibers Containing Thiazolium Groups as Wound Dressing Materials

Cited by 27 publications

References 28 publications

Development of Highly Crystalline Polylactic Acid with β-Crystalline Phase from the Induced Alignment of Electrospun Fibers

Development of Highly Crystalline Polylactic Acid with β-Crystalline Phase from the Induced Alignment of Electrospun Fibers

Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior

Tailoring of advanced poly(lactic acid)‐based materials: A review

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