Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

Tchangoue, Yvan Anderson Ngandjui; Tchamgoue, Joseph; Lunga, Paul Keilah; Knepper, Janosch; Păltinean, Ramona; Ibrom, Kerstin; Crișan, Gianina; Kouam, Siméon F.; Ali, Muhammad; Schulz, Stefan

doi:10.1016/j.fitote.2020.104527

Cited by 6 publications

(9 citation statements)

References 33 publications

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“…In addition, ten new chromene derivatives, malloapeltas C-H (12)(13)(14)(15)(16)(31)(32) and one known compound, malloapelta B (26) were isolated from the leaves of M. apelta. All compounds were evaluated for cytotoxic activity using cell counting kit-8 (CCK-8) assay against ovarian cancer cell line (TOV-21G).…”

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

“…In 2013, Harinantenaina et al isolated three phloroglucinols, mallotophenone (112), mallotojaponin B (126), and mallotojaponin C (140) from the leaves of M.oppositifolius, and evaluated cytotoxic activity on human ovarian cancer (A2780) cell line. Compounds 112, 126, and 140 showed significant cytotoxic activity against the A2780 human ovarian cancer cell line (IC 50 6.3±0.4, 1.10±0.05, and 1.3±0.1 µM, respectively) [15,51]. Recently, five prenylflavonoids, 6-prenylnaringenin (52), 7-O-methyl-6-prenylnaringenin (53), 4′-O-methyl-6prenylnaringenin (54), 7-O-methyl-8-prenylnaringenin (55), and 8-prenylnaringenin (59) obtained from M. conspurcatus exhibited cervical cancer (HeLa) cells with IC 50 values ranging from 10.08 to 60.16 µM [29].…”

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

“…In 2018, eight compounds, 3,4,8,9,10-pentahydroxydibenzo[b,d]pyran-6-one (15), gallic acid (141), methyl gallate (142), corilagin (170), repandinin B (183), mallophenol A (149), (+)lyoniresinol-3α-O-α-L-rhamnopyranoside (196), and (Z)-3-hexenyl-β-D-glucopyranoside (324) were isolated from the active fractions of M. furetianus. Compounds 149, 196, and 324 revealed potent anti-steatosis activities in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05, 0.0005 and 0.0005 µg/mL, respectively, which were much lower than the positive control, fibrate (72.4 µg/mL).…”

Section: Antioxidant and Hepatoprotective Activitiesmentioning

confidence: 99%

“…In 2020, acronyculatin S (110), acronyculatin T (210), mallotojaponin C (140), and bergenin (155) were reported from the leaves of M. oppositifolius and showed inhibitory activity against the bacterial strains E. coli, S. aureus, S. typhi, P. aeruginosa with MIC values ranging from 3.125 to 50 µg/mL [15].…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

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Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Anh

Park

Trang³

et al. 2022

Vietnam J. Sci. Technol.

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Ethnopharmacological relevance: The genus Mallotus (Euphorbiaceae family) includes 124 accepted names and distributes in tropical and sub-tropical regions. Some Mallotus species are used in traditional medicines for the treatment of chronic hepatitis, enteritis stomach, disorders, cholelithiasis, anti-cancer, gastric, and duodenal ulcers. Aim of the study: According to the Scifinder database, this is the first review study that focuses on the phytochemistry and pharmacology of Mallotus genus (17 Mallotus species) to understand the link between the traditional medicinal uses, phytochemistry, and bioactivities. Thus, they provides a scientific fundamental for further research in the phytochemical and pharmacological activities of their species. Materials and methods: Information about the Mallotus genus was collected using various databases, such as Web of Science, SciFinder, PubMed, Sci-hub, Google Scholar, Wiley, Elsevier, ACS publications, and SpringerLink between 1978 and 2021. Plant names were validated by “The Plant List” (www.theplantlist.org). Results: Up to now, total 325 compounds were reported from Mallotus species, including phloroglucinols, steroids, coumarins, benzopyrans, flavonoids, chalcones, galics, and bergenins. The extracts and phytochemical constituents of the Mallotus genus are a rich source of biologically active, including anti-cancer, anti-inflammatory, immunoregulatory, antioxidant, antibacterial, antifungal, anti-virus, and other activities. Conclusions: The review indicated that the Mallotus genus is a promising source of biological activities compounds, special anti-cancer chromanes. The results of this review confirm the great potential of Mallotus species. Thus, it will be helpful for further research in the phytochemistry and pharmacology of the Mallotus genus.

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Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

Section: Cytotoxic and Antitumor Activitiesmentioning

confidence: 99%

Section: Antioxidant and Hepatoprotective Activitiesmentioning

confidence: 99%

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

See 2 more Smart Citations

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Anh

Park

Trang³

et al. 2022

Vietnam J. Sci. Technol.

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“…Amongst these drugs, 74% were isolated from medicinal plants during phytochemical studies [ 9 ]. Thus, in our previous studies some phloroglucinols, including mallotojaponin B, were isolated from Mallotus oppositifolius and shown to possess interesting antibacterial activities [ 10 ]. Since combinatory therapy is one of the approaches in designing a new drug, the combination of natural compounds between them or with available antibiotics would be an appropriate means to fight against multi-resistant bacteria [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Potentiation effect of mallotojaponin B on chloramphenicol and mode of action of combinations against Methicillin-resistant Staphylococcus aureus

et al. 2023

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Staphylococcus aureus, the causative agent of many infectious diseases has developed resistance to many antibiotics, even chloramphenicol which was the essential antibiotic recommended for the treatment of bacterial infection. Thus, other alternatives to fight against S. aureus infections are necessary; and combinatory therapy of antibiotics with natural compounds is one of the approaches. This study evaluated the activity of the combination of mallotojaponin B and chloramphenicol against Methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial activities were evaluated by broth microdilution and the checkerboard methods. Modes of action as time-kill kinetic, Nucleotide leakage, inhibition and eradication of biofilm, and loss of salt tolerance were evaluated. Cytotoxicity was evaluated on Vero and Raw cell lines. Mallotojaponin B showed good activity against MRSA with a MIC value of 12.5 μg/mL. MRSA showed high resistance to chloramphenicol (MIC = 250 μg/mL). The combination produced a synergistic effect with a mean FICI of 0.393. This combination was bactericidal, inducing nucleotide leakage, inhibiting biofilm formation, and eradicating biofilm formed by MRSA. The synergic combination was non-cytotoxic to Vero and Raw cell lines. Thus, the combination of mallotojaponin B and chloramphenicol could be a potential alternative to design a new drug against MRSA infections.

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Searching for new agents against Enterobacteriaceae from nature: approaches, potential plant species, isolated compounds, and their respective properties

Masota,

Zehe,

Vogg

et al. 2023

Phytochem Rev

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The rising trend of antibiotic-resistant infections around the world and the low antimicrobials development pipeline volume are necessitating continued efforts in the search for novel treatment options. The prominent success from fungi and bacteria as sources of antibiotics has long motivated widespread efforts in the search for antibacterial compounds from other natural sources including plants. This review aimed at appraising the approaches and outcomes from studies commissioned to evaluate the antibacterial activities of crude plant extracts and phytochemicals. Notably, the existing traditional practices provided the greatest motivation in screening for antibacterial properties of plants, whereby the need to validate ethnomedically reported potentials formed a crucial objective. Moreover, choices of experimental techniques to address different objectives were largely dependent on the prevailing access to resources, facilities, and technical skills. The lack of streamlined guidelines dedicated to testing of crude plant extracts have resulted into broad methodological variations and lack of a standardized classification system for antibacterial activities exhibited by plant extracts. Furthermore, libraries of 128 extracts from different plant species and 122 phytochemicals substantially active against the Escherichia coli and Klebsiella pneumoniae were assembled. This enabled the elucidation of existing patterns between the Minimum Inhibitory Concentrations (MICs) and studied plant families, plant tissues, extractants, phytochemical classes, as well as the rules of drug-likeness, penetration and accumulation. The insights provided in this review will potentially impart the ongoing efforts with improved experimental designs, inspire ideas for further studies and contribute to successful hunting for new antibacterial chemical scaffolds via in silico approaches. Graphical abstract

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Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

Cited by 6 publications

References 33 publications

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Genus mallotus (euphorbiaceae): a review on traditional medicinal use, phytochemistry and biological activities

Potentiation effect of mallotojaponin B on chloramphenicol and mode of action of combinations against Methicillin-resistant Staphylococcus aureus

Searching for new agents against Enterobacteriaceae from nature: approaches, potential plant species, isolated compounds, and their respective properties

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