Antibacterial non-woven nanofibers of curcumin acrylate oligomers

Abstract

Two new (meth)acrylate monomers, namely, 4-((1E,6E)-7-(4 0 -hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6dienyl)-2-methoxyphenyl acrylate or curcumin monoacrylate (CmA) and 4-((1E,6E)-7-(4 0 -hydroxy-3methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)-2-methoxyphenyl methacrylate or curcumin monomethacrylate (CmMA), are synthesized by reacting (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione (curcumin) with acryloyl chloride and methacryloyl chloride, respectively. The respective derivatives are polymerized by free radical polymerization using an initiator, 2,2-azobisisobutyrontrile (AIBN), to obtain the oligomer of curcumin monoacrylate (OCM) and the oligomer of curcumin monomethacrylate (OCMA). The oligomers are characterized by FTIR, 1 H NMR and UV-vis spectroscopy. The molecular weights of the oligomers are determined by GPC to range between 2000 and 5500 Da. The melting temperature (T m ) and degradation temperature of the respective oligomers are evaluated by thermal analysis. The melting temperature of the oligomers ranged from 195 to 197 1C. Antibacterial studies are evaluated against Staphylococcus aureus, in which the minimum inhibitory concentration (MIC) of OCA1 is 27 mg mL À1 . The blends of the individual oligomers with poly(lactic acid) are electrospun to obtain the respective non-woven nanofiber mats. Nanofibers are formed, with the diameter ranging from 400 to 750 nm, and the nanofiber mats are porous. Because the nanofiber mats are antibacterial and highly porous, they may have potential application as a wound dressing material for tissue regeneration.

Bacterial Biofilm Formation Using PCL/Curcumin Electrospun Fibers and Its Potential Use for Biotechnological Applications

“…The aim of incorporating a natural bactericidal component like CUR [70] into the inert polymeric nanofibers of PCL is to stimulate the bacterial biofilm by provoking cellular stress in the tested bacteria [6].…”

Curcumin Acrylation for Biological and Environmental Applications

“…These materials improve the stability of curcumin for controlled release and also increase its bioavailability through enhanced solubility. Curcumin acrylation has since been used to make antibacterial nanofibers and chemical sensing materials and as a drug carrier in the form of curcumin microspheres. − Curcumin has also been explored recently for its radical scavenging potential and its capacity to inhibit toxicity of dioxin and dioxin-like molecules such as polychlorinated biphenyl (PCB) and for its potential use in environmental remediation. − The acrylation approach has similarly been used for other phenolic molecules such as apigenin and quercetin; − the identification methods discussed in this paper can be extended for these molecules and other phenols, such as myricetin and catechin. , …”

Biomimetic hydroxyapatite/poly xylitol sebacic adibate/vitamin K nanocomposite for enhancing bone regeneration

“…Few studies have presented that a topographic substrate is able to mimic an in vivo microenvironment selfpossessed of channels, pores, and ridges to support physically prompted cells at a nanoscale level [21,22]. Polyesters are generally favoured among eco-friendly polymers for both drug delivery and rejuvenative drugs due to their countless compensation, in exacting, their hydrolytic cleavage in the hydrophilic environment in vivo [23][24][25]. The dicarboxylic acids worn in this exertion were sebacic acid, adipic acids that have been exposed to be cytocompatible [26,27].…”