Antibacterial nanopatterned coatings for dental implants

Fontelo, R.; Costa, Diana Soares da; Gomez‐Florit, Manuel; Tiainen, Hanna; Reis, Rui L.; Novoa-Carballal, Ramón; Pashkuleva, Iva

doi:10.1039/d2tb01352e

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…Mainly, various osteoinductive growth factors are used [11,375,388]. Moreover, to decrease the risk of infectious complication development, the application of antibacterial preparations on the implant surface [20,389,390] and introduction of metal particles (antibacterial components such as Cu, Zn, Ag, and Ga) into the implant surface or into the coating composition are widely used [16][17][18][19]117,149,163,164,232,251].…”

Section: Biochemical Techniquesmentioning

confidence: 99%

Dental Implants: Modern Materials and Methods of Their Surface Modification

Sotova,

Yanushevich,

Kriheli

et al. 2023

Materials

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The development of dental implantology is based on the detailed study of the interaction of implants with the surrounding tissues and methods of osteogenesis stimulation around implants, which has been confirmed by the increasing number of scientific publications presenting the results of studies related to both the influence of the chemical composition of dental implant material as well as the method of its surface modification on the key operational characteristics of implants. The main materials for dental implant manufacturing are Ti and its alloys, stainless steels, Zr alloys (including ceramics based on ZrO2), and Ta and its alloys, as well as other materials (ceramics based on Al2O3, Si3N4, etc.). The review presents alloy systems recommended for use in clinical practice and describes their physical–mechanical and biochemical properties. However, when getting into the body, the implants are subjected to various kinds of mechanical influences, which are aggravated by the action of an aggressive biological environment (electrolyte with a lot of Cl− and H+); it can lead to the loss of osteointegration and to the appearance of the symptoms of the general intoxication of the organism because of the metal ions released from the implant surface into the biological tissues of the organism. Since the osteointegration and biocompatibility of implants depend primarily on the properties of their surface layer (it is the implant surface that makes contact with the tissues of the body), the surface modification of dental implants plays an important role, and all methods of surface modification can be divided into mechanical, physical, chemical, and biochemical methods (according to the main effect on the surface). This review discusses several techniques for modifying dental implant surfaces and provides evidence for their usefulness.

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Section: Biochemical Techniquesmentioning

confidence: 99%

Dental Implants: Modern Materials and Methods of Their Surface Modification

Sotova,

Yanushevich,

Kriheli

et al. 2023

Materials

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“…Implant−associated infection can arise at any time, but the first four weeks post implantation are the most vulnerable, as the interface between the implant and the surrounding bone is weak [10]. Therefore, efforts have been focused on designing strategies to impart anti−infective properties to the implant surface to arrest bacterial colonization on the surface [11][12][13][14]. Most of these modifications rely on restricting bacterial adhesion (anti−adhesive), reducing colonization (antibacterial and thus anti−proliferative), or targeting biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

Chemoselective Coatings of GL13K Antimicrobial Peptides for Dental Implants

Mutreja,

Lan,

et al. 2023

Pharmaceutics

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Dental implant−associated infection is a clinical challenge which poses a significant healthcare and socio−economic burden. To overcome this issue, developing antimicrobial surfaces, including antimicrobial peptide coatings, has gained great attention. Different physical and chemical routes have been used to obtain these biofunctional coatings, which in turn might have a direct influence on their bioactivity and functionality. In this study, we present a silane−based, fast, and efficient chemoselective conjugation of antimicrobial peptides (Cys−GL13K) to coat titanium implant surfaces. Comprehensive surface analysis was performed to confirm the surface functionalization of as−prepared and mechanically challenged coatings. The antibacterial potency of the evaluated surfaces was confirmed against both Streptococcus gordonii and Streptococcus mutans, the primary colonizers and pathogens of dental surfaces, as demonstrated by reduced bacteria viability. Additionally, human dental pulp stem cells demonstrated long−term viability when cultured on Cys−GL13K−grafted titanium surfaces. Cell functionality and antimicrobial capability against multi−species need to be studied further; however, our results confirmed that the proposed chemistry for chemoselective peptide anchoring is a valid alternative to traditional site−unspecific anchoring methods and offers opportunities to modify varying biomaterial surfaces to form potent bioactive coatings with multiple functionalities to prevent infection.

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Preparation, Properties, and Bioapplications of Block Copolymer Nanopatterns

Fontelo,

Reis,

Novoa‐Carballal

et al. 2023

Adv Healthcare Materials

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Block copolymer (BCP) self‐assembly has emerged as a feasible method for large‐scale fabrication with remarkable precision – features that are not common for most of the nanofabrication techniques. In this review, we present recent advancements in the molecular design of BCP along with state‐of‐the‐art processing methodologies based on microphase separation alone or its combination with different lithography methods. Furthermore, we explore the bioapplications of the generated nanopatterns in the development of protein arrays, cell‐selective surfaces, and antibacterial coatings. Finally, we outline the current challenges in the field and discuss the potential breakthroughs that can be achieved by adopting BCP approaches already applied in the fabrication electronic devices.This article is protected by copyright. All rights reserved

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Antibacterial nanopatterned coatings for dental implants

Abstract: Dental implants, usually made of titanium, are exposed to hostile oral microflora that facilitates bacterial infections and subsequent inflammation. To mitigate these processes, we coated titanium substrates with block copolymer...

Cited by 4 publications

References 51 publications

Dental Implants: Modern Materials and Methods of Their Surface Modification

Dental Implants: Modern Materials and Methods of Their Surface Modification

Chemoselective Coatings of GL13K Antimicrobial Peptides for Dental Implants

Preparation, Properties, and Bioapplications of Block Copolymer Nanopatterns

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