Antibacterial Nanocarbons: Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection (Adv. Funct. Mater. 33/2019)

Yang, Yuliang; Deng, Yiyi; Huang, Jianbo; Fan, Xin; Cheng, Chong; Nie, Chuanxiong; Ma, Lang; Zhao, Weifeng; Zhao, Changsheng

doi:10.1002/adfm.201970225

Cited by 29 publications

(34 citation statements)

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“…As shown in Figure A2, the CCK-8 results revealed that the ZIF-8-ICG prepared in this research was cytocompatible. Subsequently, to further investigate whether the injection of nanoparticles into wound skin will induce cumulative toxicity to animal organs, the histological analyses of the heart, liver, spleen, lung, and kidney was performed on treated mice and healthy mice without bacterial infection [23]. As shown in Figure 8, the H&E stained sections of all samples were similar to the healthy group without apparent abnormities, such as swelling, ulceration, and erosion.…”

Section: Resultsmentioning

confidence: 99%

“…Their spatial confinement of porous structure is beneficial to stabilizing guest molecules, restricting molecules movement, and subsequently avoiding aggregation [21,22]. During the degradation process of MOFs, metal ions such as Ag + and Zn 2+ ions can be liberated and further contribute to damaging bacteria by directly disrupting bacterial membrane and intracellular proteins for chemotherapy [23].…”

Section: Introductionmentioning

confidence: 99%

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Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Zhou

et al. 2019

Pharmaceutics

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Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Zhou

et al. 2019

Pharmaceutics

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“…To trap MOFs in omniphobic hydrogel, wound dressing not only protects MOFs from degradation in physiological fluids, but also prevents the burst release of metal ions that could be toxic 25,27–29. In addition to their bactericidal and anti‐inflammatory properties, the slowly released copper and zinc ions have shown to accelerate wound healing by promoting cell migration, angiogenesis, and collagen deposition 25,28,29,32,33. Benefiting from a microfluidic‐emulsion‐templated method, we successfully encapsulate a model example of MOFs, zeolitic imidazolate framework‐8 (ZIF‐8), in a well‐defined porous polyvinyl alcohol (PVA) hydrogel membrane with exquisite reentrant microstructures 20,21,34,35.…”

Section: Introductionmentioning

confidence: 99%

Omniphobic ZIF‐8@Hydrogel Membrane by Microfluidic‐Emulsion‐Templating Method for Wound Healing

Yao

Zhu

et al. 2020

Adv Funct Materials

150

135

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Bacterial adhesion and colonization can result in chronic non‐healing wounds. Current hydrophilic wound dressings can release antibacterial agents into the wound exudate, but may result in overhydrated wounds, bacterial overgrowth, and even tissue maceration. Hydrophobic dressings are anti‐fouling, though ineffective to encapsulate and release bactericidal agents. Combining the advantages of hydrophilic and hydrophobic dressings seems difficult, until the development of superwettability surfaces offers an opportunity for omniphobic dressings from intrinsic hydrophilic polymers. Herein, omniphobic porous hydrogel wound dressings loaded with a zinc imidazolate framework 8 (ZIF‐8) are fabricated by a microfluidic‐emulsion‐templating method. The fabricated porous hydrogel membrane with its reentrant architecture is repellent to blood and body fluids, though intrinsically hydrophilic. This unique combination not only reduces the adhesion of harmful microbes, but also enables the encapsulation and release of antibacterial ingredients to wounded sites from hydrophilic polymer networks. As such, the omniphobic metal‐organic frameworks (MOFs)@hydrogel porous wound dressing can inhibit bacteria invasion and enable the controlled release of the bactericidal, anti‐inflammatory, and nontoxic zinc ions. Furthermore, in vivo study of infected full‐thickness skin defect models demonstrates that the dressing also accelerates wound closure by promoting angiogenesis and collagen deposition. Therefore, the omniphobic MOFs@hydrogel porous wound dressings are potentially useful for clinical application.

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“…In this work, motivated by their advantages of Zn‐based MOF‐derived nanocarbons, [ 47,52,54,55 ] we have constructed C‐ZnO nanocarbons‐modified fibrous scaffolds for stem cell‐based osteogenic differentiation. Although ZIF‐8 is size‐morphology tunable and could contain multiple metal ions, they are not quite stable, especially in the acidic environment.…”

Section: Introductionmentioning

confidence: 99%

ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation

Xia

Fan

Yang

et al. 2020

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Currently, mesenchymal stem cells (MSCs)-based therapies for bone regeneration and treatments have gained significant attention in clinical research. Though many chemical and physical cues which influence the osteogenic differentiation of MSCs have been explored, scaffolds combining the benefits of Zn 2+ ions and unique nanostructures may become an ideal interface to enhance osteogenic and anti-infective capabilities simultaneously. In this work, motivated by the enormous advantages of Zn-based metal-organic frameworkderived nanocarbons, C-ZnO nanocarbons-modified fibrous scaffolds for stem cell-based osteogenic differentiation are constructed. The modified scaffolds show enhanced expression of alkaline phosphatase, bone sialoprotein, vinculin, and a larger cell spreading area. Meanwhile, the caging of ZnO nanoparticles can allow the slow release of Zn 2+ ions, which not only activate various signaling pathways to guide osteogenic differentiation but also prevent the potential bacterial infection of implantable scaffolds. Overall, this study may provide new insight for designing stem cell-based nanostructured fibrous scaffolds with simultaneously enhanced osteogenic and anti-infective capabilities.

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Antibacterial Nanocarbons: Size‐Transformable Metal–Organic Framework–Derived Nanocarbons for Localized Chemo‐Photothermal Bacterial Ablation and Wound Disinfection (Adv. Funct. Mater. 33/2019)

Cited by 29 publications

References 0 publications

Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Omniphobic ZIF‐8@Hydrogel Membrane by Microfluidic‐Emulsion‐Templating Method for Wound Healing

ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation

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