Antibacterial nano cerium oxide/chitosan/cellulose acetate composite films as potential wound dressing

Kalaycıoğlu, Zeynep; Kahya, Nilay; Adımcılar, Veselina; Kaygusuz, Hakan; Torlak, Emrah; Akın-Evingür, Gülşen; Erim, F. Bedia

doi:10.1016/j.eurpolymj.2020.109777

Cited by 80 publications

(53 citation statements)

References 29 publications

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“…This observation corroborates the hypothesis about additional intermolecular interactions, the CeO 2 nanoparticles acting as links. A similar reduction in the degree of swelling in water was observed in nanocomposite films consisting of a mixture of chitosan with cellulose acetate filled with CeO 2 nanoparticles [ 43 ].…”

Section: Resultssupporting

confidence: 55%

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

et al. 2021

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A technique for the fabrication of bacterial cellulose-based films with CeO2 nanofiller has been developed. The structural and morphological characteristics of the materials have been studied, their thermal and mechanical properties in dry and swollen states having been determined. The preparation methodology makes it possible to obtain composites with a uniform distribution of nanoparticles. The catalytic effect of ceria, regarding the thermal oxidative destruction of cellulose, has been confirmed by TGA and DTA methods. An increase in CeO2 content led to an increase in the elastic modulus (a 1.27-fold increase caused by the introduction of 5 wt.% of the nanofiller into the polymer) and strength of the films. This effect is explained by the formation of additional links between polymer macro-chains via the nanoparticles’ surface. The materials fabricated were characterized by a limited ability to swell in water. Swelling caused a 20- to 30-fold reduction in the stiffness of the material, the mechanical properties of the films in a swollen state remaining germane to their practical use. The application of the composite films in cell engineering as substrates for the stem cells’ proliferation has been studied. The increase in CeO2 content in the films enhanced the proliferative activity of embryonic mouse stem cells. The cells cultured on the scaffold containing 5 wt.% of ceria demonstrated increased cell survival and migration activity. An analysis of gene expression confirmed improved cultivation conditions on CeO2-containing scaffolds.

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Section: Resultssupporting

confidence: 55%

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

et al. 2021

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“…The most widely used natural film-forming biopolymers are α- (starch, dextran) or β- (cellulose) polyglucans and anionic polysaccharides (pectin, alginate), proteins (gelatin, elastin, collagen) and cationic chitosan derivatives. In order to improve the antibacterial, thermal and mechanical properties of the polymer composite material, Kalaycioğlu et al loaded a chitosan/cellulose acetate film with nanosized cerium oxide [ 64 ]. The physical properties and antibacterial characteristics of the films obtained showed promise as a wound dressing material.…”

Section: Wound Dressings and Other Topical Applications For Ceria-mentioning

confidence: 99%

“…Polyvinyl alcohol/chitosan hydrogel supplemented with 0.5% of CeNPs showed good antibacterial activity after just 12 h (against methicillin-resistant Staphylococcus aureus ) and healthy human dermal fibroblast viabilities up to five days (more than 90%) compared to the control group [ 62 ]. Chitosan and cellulose acetate polymer composites filled with CeNPs as potential wound dressing materials have also demonstrated good antibacterial characteristics [ 64 ]. Fei et al developed ceria-functionalized gelatin polycaprolactone nanofiber (PCLNPNF) matrices using electrospun methods; the antibacterial property of the PCLNPNF showed remarkable activity against both gram-positive ( S. aureus ), and gram-negative ( P. aeruginosa ), bacteria.…”

Section: Ceria-containing Antibacterial and Antiviral Multifunctiomentioning

confidence: 99%

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

et al. 2021

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The development of advanced composite biomaterials combining the versatility and biodegradability of polymers and the unique characteristics of metal oxide nanoparticles unveils new horizons in emerging biomedical applications, including tissue regeneration, drug delivery and gene therapy, theranostics and medical imaging. Nanocrystalline cerium(IV) oxide, or nanoceria, stands out from a crowd of other metal oxides as being a truly unique material, showing great potential in biomedicine due to its low systemic toxicity and numerous beneficial effects on living systems. The combination of nanoceria with new generations of biomedical polymers, such as PolyHEMA (poly(2-hydroxyethyl methacrylate)-based hydrogels, electrospun nanofibrous polycaprolactone or natural-based chitosan or cellulose, helps to expand the prospective area of applications by facilitating their bioavailability and averting potential negative effects. This review describes recent advances in biomedical polymeric material practices, highlights up-to-the-minute cerium oxide nanoparticle applications, as well as polymer-nanoceria composites, and aims to address the question: how can nanoceria enhance the biomedical potential of modern polymeric materials?

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“…As polymeric constructs provide suitable soft-tissue replacements, CNP-incorporated nanofibers, films, and hydrogels were developed and used for managing infectious wounds [ 36 , 94 , 95 ]. More recently, chitosan and cellulose acetate composite films containing CNPs (0.1% (w/v) and 1% (w/v)) were prepared as potential wound dressings [ 96 ]. The inhibitory effects of the CNP-containing films against Staphylococcus aureus ( S. aureus ) and E. coli bacteria proved their antibacterial activity; increasing CNP amounts in the films resulted in considerable antibacterial activity.…”

Section: Nanoceria: Biological Superiorities For Soft-tissue Healimentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Antibacterial nano cerium oxide/chitosan/cellulose acetate composite films as potential wound dressing

Cited by 80 publications

References 29 publications

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

CeO2 Nanoparticle-Containing Polymers for Biomedical Applications: A Review

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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