Antibacterial, modulatory activity of antibiotics and toxicity from Rhinella jimi (Stevaux, 2002) (Anura: Bufonidae) glandular secretions

Sales, Débora Lima; Morais-Braga, Maria Flaviana Bezerra; Santos, Antônia Thassya Lucas dos; Machado, Antônio Júdson Targino; Filho, João Antonio de Araújo; Dias, Diógenes de Queiroz; Cunha, Francisco Assis Bezerra da; Saraiva, Rogério de Aquino; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Costa, José Galberto Martins da; Ferreira, Felipe Silva; Alves, Rômulo Romeu Nóbrega; Almeida, Waltécio de Oliveira

doi:10.1016/j.biopha.2017.05.098

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…Although plants produce large number of antimicrobial compounds, however, in general plant-derived antimicrobials are less potent compared to antimicrobials isolated from bacteria and fungi (Hemaiswarya et al 2008;Salam and Quave, 2018). Particularly large number of studies revealed that only in rare cases, plant crude extracts had clinically relevant MIC values (less than 100 µg ml À1 for crude extracts and less than 10 µg ml À1 for pure compounds; Cos et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies were performed exploring antibiotic modulatory activities of many plant materials and a number of promising antibiotic and plant extract combinations were found (Olajuyigbe and Afolayan, 2012;Fankam et al 2015Fankam et al , 2017Morais et al 2017;Sales et al 2017;Nayim et al 2018). However, antibiotic modulatory activity of A. eupatoria, H. alpestre, R. obtusifolius and S. officinalis was shown for the first time.…”

Section: Discussionmentioning

confidence: 99%

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Novel approach to combat antibiotic resistance: evaluation of some Armenian herb crude extracts for their antibiotic modulatory and antiviral properties

Ginovyan

Trchоunian

2019

J of Applied Microbiology

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Aims One of the strategies to combat antibiotic resistance can be the use of plant materials in combination with antibiotics, taking into account that phytochemicals can act as antibiotic resistance‐modifying agents. This can give a second life to the traditional antibiotics. The aim was to evaluate antibiotic modulatory effect of crude extracts from Agrimonia eupatoria, Hypericum alpestre, Rumex obtusifolius and Sanguisorba officinalis herbs towards several commercial antibiotics using some Gram‐positive and Gram‐negative bacteria. Methods The antibiotic modulatory activity was tested by determining MICs of antibiotics in the absence and presence of plant crude extracts at subinhibitory concentrations. Antiviral potential of different extracts of tested plant materials was also explored by double overlay plaque assay. Results The tested plant crude extracts exhibited high modulatory activity towards used antibiotics. Particularly, high modulatory activity was observed with extracts of H. alpestre and R. obtusifolius. Many plant‐antibiotic combinations induced the decrease in MICs of antibiotics up to ~fourfold indicating synergy. Moreover, the similar change was observed at both subinhibitory concentrations (MIC/2 and MIC/4) of the same plant crude extract. High anti‐phage activity of plants with the exception of Lilium armenum against T4 phage of Escherichia coli C‐T4 was also shown. Conclusions Plant crude extract or commercial antibiotic combinations significantly increased the efficiency of antibiotics. Tested plant materials with exception of L. armenum have antiviral property. Significance and Impact of the Study For the first time, antibiotic modulatory activity of tested herb extracts was shown, which could have potential in practical applications. Tested plant materials with exception of L. armenum could have prospective, as a source of new antiviral compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Novel approach to combat antibiotic resistance: evaluation of some Armenian herb crude extracts for their antibiotic modulatory and antiviral properties

Ginovyan

Trchоunian

2019

J of Applied Microbiology

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“…The water-soluble secretion of the parotid gland and the methanolic extract of the skin of the Sudanese toad Duttaphrynus melanostictus showed antibiotic activity against Bacillus cereus , Escherichia coli , Klebsiella pneumoniae , Salmonella typhimurium , Staphylococcus aureus , and Staphylococcus epidermidis ; however, no action was found against methicillin-resistant S. aureus [ 33 ]. Sales et al [ 34 ] observed that combining antibiotics of the aminoglycoside and β-lactam groups with the glandular secretion of Rhinella jimi led to a significant reduction in the minimal inhibitory concentration (MIC) value, mainly in strains of E. coli , Pseudomonas aeruginosa , and S. aureus . This indicated that components of the venom of R. jimi have significant pharmaceutical value in combination with available antibiotics.…”

Section: Antimicrobial Activities Of Compounds From Toads’ Cutaneous ...mentioning

confidence: 99%

Antimicrobial Compounds from Skin Secretions of Species That Belong to the Bufonidae Family

Ibarra-Vega

Salazar-Monge

Zatarain-Palacios

et al. 2023

Toxins

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Skin secretions of toads are a complex mixture of molecules. The substances secreted comprise more than 80 different compounds that show diverse pharmacological activities. The compounds secreted through skin pores and parotid glands are of particular interest because they help toads to endure in habitats full of pathogenic microbes, i.e., bacteria, fungi, viruses, and protozoa, due to their content of components such as bufadienolides, alkaloids, and antimicrobial peptides. We carried out an extensive literature review of relevant articles published until November 2022 in ACS Publications, Google Scholar, PubMed, and ScienceDirect. It was centered on research addressing the biological characterization of the compounds identified in the species of genera Atelopus, Bufo, Duttaphrynus, Melanophryniscus, Peltopryne, Phrynoidis, Rhaebo, and Rhinella, with antibacterial, antifungal, antiviral, and antiparasitic activities; as well as studies performed with analogous compounds and skin secretions of toads that also showed these activities. This review shows that the compounds in the secretions of toads could be candidates for new drugs to treat infectious diseases or be used to develop new molecules with better properties from existing ones. Some compounds in this review showed activity against microorganisms of medical interest such as Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Coronavirus varieties, HIV, Trypanosoma cruzi, Leishmania chagasi, Plasmodium falciparum, and against different kinds of fungi that affect plants of economic interest.

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“…Studies with species belonging to the Rhinella genus have identified the presence of different saturated fatty acids, including lauric acid, myristic acid, pentadecanoic acid, stearic acid, palmitic acid and heptadecanoic acid, and of unsaturated fatty acids, including arachidonic acid, linoleic acid, oleic acid and palmitolytic acid, in fixed oils obtained from the body fat of Rhinella jimi frogs (Stevaux 2002) (Sales et al 2015).…”

Section: Zoopharmacognosy and Zoopharmacology In The Caatingamentioning

confidence: 99%

“…Moreover, the study by Sales et al (2017) analyzed secretions obtained from the parotid glands of the aforementioned species and identified the presence of bufotenin, dehydrobufotenin, marinobufagine, telocinobufagine, and bufaline. Similar constituents were also identified in venom extracted from Bufo schneideri Werner, namely, marinobufagine, telocinobufagine and bufaline (Freitas 2003).…”

Section: Zoopharmacognosy and Zoopharmacology In The Caatingamentioning

confidence: 99%

Medicinal plants and animals of an important seasonal dry forest in Brazil

Albuquerque¹,

Brito²,

Nascimento³

et al. 2020

Ethnobio Conserv

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Research performed in recent years indicates that efforts are still needed to understand the advances in the Caatinga, an important dry seasonal forest, and identify its potential for bioprospecting. These efforts are also important for pinpointing the challenges that should be addressed in future research focused on identifying new candidates for pharmacological studies in this complex region. Thus, in this review, we present the main advances of studies on plants and medicinal animals in the Caatinga region and their implications for ethnopharmacology, and we then discuss future challenges to promote the search for candidates with pharmacological potential. Based on an exploration of the available literature, we performed a critical reading of the available evidence to provide a good scenario on the studies in the region. We find that despite the large number of studies available, it is necessary to organize efforts to fill gaps in different areas of knowledge and optimize the search for new natural products.

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Antibacterial, modulatory activity of antibiotics and toxicity from Rhinella jimi (Stevaux, 2002) (Anura: Bufonidae) glandular secretions

Cited by 12 publications

References 45 publications

Novel approach to combat antibiotic resistance: evaluation of some Armenian herb crude extracts for their antibiotic modulatory and antiviral properties

Novel approach to combat antibiotic resistance: evaluation of some Armenian herb crude extracts for their antibiotic modulatory and antiviral properties

Antimicrobial Compounds from Skin Secretions of Species That Belong to the Bufonidae Family

Medicinal plants and animals of an important seasonal dry forest in Brazil

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