Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria

Song, Lianyu; Hu, Xin; Ren, Xiaomin; Liu, Jing; Liu, Xiaoye

doi:10.3389/fphar.2022.873374

Cited by 24 publications

(23 citation statements)

References 93 publications

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“…These compounds have various bioactivities, such as antioxidation, antibiosis, an estrogen-like effect, and the prevention and treatment of cardiovascular diseases [ 6 , 31 , 32 ]. After some of them were discovered to have the potency to enhance the antibacterial effect of some antibiotics and/or even reverse the AMR [ 6 , 7 ], their antibacterial activities have been increasingly receiving close attention [ 8 , 9 , 10 , 11 , 12 ]. However, the antimicrobial activities of most flavonoids remain unknown after being discovered.…”

Section: Discussionmentioning

confidence: 99%

“…However, some plant metabolites with moderate antimicrobial activities [ 5 ], being nontoxic to the human body, can enhance the antibacterial activity of some antibiotics, and even reverse the AMR [ 6 , 7 ]. Among them, plant flavonoids have received close attention [ 8 , 9 , 10 , 11 , 12 ]. Some of their structure–activity relationships against bacteria were summarized in various degrees [ 7 , 8 , 13 , 14 ], together with some sporadic ones [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Quantitative Relationship and Mechanism of Plant Flavonoids to Gram-Positive Bacteria

et al. 2022

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Antimicrobial resistance (AMR) poses a serious threat to human health, and new antimicrobial agents are desperately needed. Plant flavonoids are increasingly being paid attention to for their antibacterial activities, for the enhancing of the antibacterial activity of antimicrobials, and for the reversing of AMR. To obtain more scientific and reliable equations, another two regression equations, between the minimum inhibitory concentration (MIC) (y) and the lipophilicity parameter ACD/LogP or LogD7.40 (x), were established once again, based on the reported data. Using statistical methods, the best one of the four regression equations, including the two previously reported, with regard to the antimicrobial quantitative relationship of plant flavonoids to Gram-positive bacteria, is y = −0.1285 x6 + 0.7944 x5 + 51.785 x4 − 947.64 x3 + 6638.7 x2 − 21,273 x + 26,087; here, x is the LogP value. From this equation, the MICs of most plant flavonoids to Gram-positive bacteria can be calculated, and the minimum MIC was predicted as approximately 0.9644 μM and was probably from 0.24 to 0.96 μM. This more reliable equation further proved that the lipophilicity is a key factor of plant flavonoids against Gram-positive bacteria; this was further confirmed by the more intuitive evidence subsequently provided. Based on the antibacterial mechanism proposed in our previous work, these also confirmed the antibacterial mechanism: the cell membrane is the major site of plant flavonoids acting on the Gram-positive bacteria, and this involves the damage of the phospholipid bilayers. The above will greatly accelerate the discovery and application of plant flavonoids with remarkable antibacterial activity and the thorough research on their antimicrobial mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Quantitative Relationship and Mechanism of Plant Flavonoids to Gram-Positive Bacteria

et al. 2022

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“…Besides, actinomycetes and marine natural products were also vital sources ( Hou, et al, 2019 ; Jagannathan, et al, 2021 ; Zhu, et al, 2014 ). The notable active components were flavonoids ( Song, et al, 2022 ), alkaloids and phenolics ( Suganya, et al, 2022 ). Essential oil ( Badescu, et al, 2022 ), polyphenols ( Jubair, et al, 2021 ), and berberine ( Yu, et al, 2005 ) were also included in the co-occurrence keywords.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of natural products against MDR bacteria: A scientometric visualization analysis

Zhou

Cao²,

Peng³

2022

Front. Pharmacol.

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Objective: A growing number of studies have demonstrated the antimicrobial activity of natural products against multidrug-resistant bacteria. This study aimed to apply scientometric method to explore the current status and future trends in this field.Methods: All relevant original articles and reviews for the period 1997–2021 were retrieved from the Web of Science Core Collection database. VOSviewer, a scientometric software, and an online bibliometric analysis platform were used to conduct visualization study.Results: A total of 1,267 papers were included, including 1,005 original articles and 262 reviews. The United States and India made the largest contribution in this field. The University of Dschang from Cameroon produced the most publications. Coutinho HDM, Kuete V, and Gibbons S were key researchers, as they published a great many articles and were co-cited in numerous publications. Frontiers in Microbiology and Antimicrobial Agents and Chemotherapy were the most influential journals with the highest number of publications and co-citations, respectively. “Medicinal plants”, “methicillin-resistant Staphylococcus aureus”, “biofilm”, “minimum inhibitory concentration”, and “efflux pumps” were the most frequently used keywords, so these terms are presumed to be the current hot topics. All the included keywords could be roughly divided into four major themes, of which the theme of “natural product development approach” had attracted much attention in recent years. Furthermore, “Pseudomonas aeruginosa”, “nanoparticles”, “green synthesis”, “antimicrobial peptides”, “antibiofilm”, “biosynthetic gene clusters”, and “molecular dynamics simulation” had the latest average appearance year, indicating that these topics may become the research hot spots in the coming years.Conclusion: This study performed a scientometric analysis of the antibacterial activity of natural products against multidrug-resistant bacteria from a holistic perspective. It is hoped to provide novel and useful data for scientific research, and help researchers to explore this field more intuitively and effectively.

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“…In addition to inhibiting bacterial activity through direct inhibition, flavonoids have been shown to exert synergistic effects with antibiotics, such as inhibiting the expression of β-lactamases that produce antibiotic resistance in bacteria ( 82 ). To inhibit drug resistant bacteria, flavonoids can serve as inhibitors of bacterial efflux pumps and virulence factors, for example, quercetin strongly reduces extracellular matrix targeting to disrupt E. coli colonic biofilms, whereas apigenin restores antibiotic susceptibility to drug-resistant bacteria and limits the spread of drug-resistant bacteria by activating the host innate immune system ( 83 ). Also, flavonoids have antibacterial effects in slightly alkaline conditions.…”

Section: Effect Of Flavonoids To Promote Scar-free Regenerationmentioning

confidence: 99%

The potential of functionalized dressing releasing flavonoids facilitates scar-free healing

et al. 2022

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Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kinase, and yes-related transcriptional regulators at infancy or the oral mucosa is thought to be the reason of scarless regenerative capacity after tissue defects. Currently, tissue engineering products for defect repair frequently overlook the management of postoperative scars, and inhibitors of important genes alone have negative consequences for the organism. Natural flavonoids have hemostatic, anti-inflammatory, antioxidant, and antibacterial properties, which promote wound healing and have anti-scar properties by interfering with the transmission of key signaling pathways involved in scar formation. The combination of flavonoid-rich drug dressings provides a platform for clinical translation of compounds that aid in drug disintegration, prolonged release, and targeted delivery. Therefore, we present a review of the mechanisms and effects of flavonoids in promoting scar-free regeneration and the application of flavonoid-laden dressings.

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Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria

Cited by 24 publications

References 93 publications

Antimicrobial Quantitative Relationship and Mechanism of Plant Flavonoids to Gram-Positive Bacteria

Antimicrobial Quantitative Relationship and Mechanism of Plant Flavonoids to Gram-Positive Bacteria

Antimicrobial activity of natural products against MDR bacteria: A scientometric visualization analysis

The potential of functionalized dressing releasing flavonoids facilitates scar-free healing

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