Antibacterial metals and alloys for potential biomedical implants

Zhang, Erlin; Zhao, Xiaotong; Hu, Jiali; Wang, Ruoxian; Fu, Shuangcheng; Qin, Gaowu

doi:10.1016/j.bioactmat.2021.01.030

Cited by 297 publications

(162 citation statements)

References 394 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…To retain its original properties, the alloy is also imparted with continuous antibacterial properties, which is a novel method to prevent and treat IAI. The specific mechanism of the antibacterial action of alloys is complicated (Zhang et al, 2021a), and to date, four potential antibacterial mechanisms have been proposed. First, when the intermetallic phase precipitated on the alloy surface comes into contact with bacteria, contact killing can destroy the outer bacterial membrane, prevent bacterial adhesion, and inhibit biofilm formation.…”

Section: Antibacterial Mechanisms Of Alloysmentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Implants are widely used in orthopedic surgery and are gaining attention of late. However, their use is restricted by implant-associated infections (IAI), which represent one of the most serious and dangerous complications of implant surgeries. Various strategies have been developed to prevent and treat IAI, among which the closest to clinical translation is designing metal materials with antibacterial functions by alloying methods based on existing materials, including titanium, cobalt, tantalum, and biodegradable metals. This review first discusses the complex interaction between bacteria, host cells, and materials in IAI and the mechanisms underlying the antibacterial effects of biomedical metals and alloys. Then, their applications for the prevention and treatment of IAI are highlighted. Finally, new insights into their clinical translation are provided. This review also provides suggestions for further development of antibacterial metals and alloys.

show abstract

Section: Antibacterial Mechanisms Of Alloysmentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…In recent years, emerging nanozymes have become a new generation of antibiotics due to their broad-spectrum antibacterial activity, low toxicity, and no drug resistance [ 5 , 6 ]. Generally, nanozymes with peroxidase-like activity specifically catalyze the conversion of hydrogen peroxide (H 2 O 2 ) into highly toxic reactive oxygen species (ROS), such as hydroxyl radicals (•OH), to attack the bacterial membranes of weakly acidic infection sites [ 7 , 8 ]. Previous studies have shown that ROS is an important factor for the immune system to perform antibacterial effects, where ROS can kill bacteria by destroying their cell membranes, DNA, proteins, etc.…”

Section: Introductionmentioning

confidence: 99%

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Wang

Shi

Zha

et al. 2021

Bioactive Materials

208

171

View full text Add to dashboard Cite

Nanozymes have become a new generation of antibiotics with exciting broad-spectrum antibacterial properties and negligible biological toxicity. However, their inherent low catalytic activity limits their antibacterial properties. Herein, Cu single-atom sites/N doped porous carbon (Cu SASs/NPC) is successfully constructed for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolysis (PEAP) strategy. Cu SASs/NPC have stronger peroxidase-like catalytic activity, glutathione (GSH)-depleting function, and photothermal property compared with non-Cu-doped NPC, indicating that Cu doping significantly improves the catalytic performance of nanozymes. Cu SASs/NPC can effectively induce peroxidase-like activity in the presence of H 2 O 2 , thereby generating a large amount of hydroxyl radicals (•OH), which have a certain killing effect on bacteria and make bacteria more susceptible to temperature. The introduction of near-infrared (NIR) light can generate hyperthermia to fight bacteria, and enhance the peroxidase-like catalytic activity, thereby generating additional •OH to destroy bacteria. Interestingly, Cu SASs/NPC can act as GSH peroxidase (GSH-Px)-like nanozymes, which can deplete GSH in bacteria, thereby significantly improving the sterilization effect. PTT-catalytic synergistic antibacterial strategy produces almost 100% antibacterial efficiency against Escherichia coli ( E. coli ) and methicillin-resistant Staphylococcus aureus ( MRSA ). In vivo experiments show a better PTT-catalytic synergistic therapeutic performance on MRSA-infected mouse wounds. Overall, our work highlights the wide antibacterial and anti-infective bio-applications of Cu single-atom-containing catalysts.

show abstract

“…Since the majority of implant-related infections are associated with biofilm formation on the implant surface, several strategies have been investigated to reduce bacterial adhesion on titanium surfaces. Among them, the localized release of antibiotics, organic or inorganic antibacterial agents, such as metal ions or nanoparticles, can be cited [9][10][11][12]. Finally, topographical modifications should be synergistically designed to be suitable for both the optimization of tissue integration and infection passive prevention, such as through surface nanotextures [13][14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

et al. 2021

View full text Add to dashboard Cite

Nano- and micro-structuring of implantable materials constitute a promising approach to introduce mechanical contact guidance effect, drive cells colonization, as well as to prevent bacteria adhesion and biofilm aggregation, through antifouling topography. Accordingly, this paper aims to extend the application of e-beam surface texturing and nano-structuring to the beta titanium alloys, which are of great interest for biomedical implants because of the low Young modulus and the reduction of the stress shielding effect. The paper shows that surface texturing on the micro-scale (micro-grooves) is functional to a contact guidance effect on gingival fibroblasts. Moreover, nano-structuring, derived from the e-beam surface treatment, is effective to prevent microfouling. In fact, human fibroblasts were cultivated directly onto grooved specimens showing to sense the surface micro-structure thus spreading following the grooves’ orientation. Moreover, Staphylococcus aureus colonies adhesion was prevented by the nano-topographies in comparison to the mirror-polished control, thus demonstrating promising antifouling properties. Furthermore, the research goes into detail to understand the mechanism of microfouling prevention due to nano-topography and microstructure.

show abstract

Antibacterial metals and alloys for potential biomedical implants

Cited by 297 publications

References 394 publications

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Copper single-atom catalysts with photothermal performance and enhanced nanozyme activity for bacteria‐infected wound therapy

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

Contact Info

Product

Resources

About