Antibacterial Metal Oxide Nanoparticles: Challenges in Interpreting the Literature

Kadiyala, Usha; Kotov, Nicholas A.; VanEpps, J. Scott

doi:10.2174/1381612824666180219130659

Cited by 110 publications

(71 citation statements)

References 65 publications

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“…Metal oxides NPs are among one of the most explored and studied family of NPs and are known to effectively inhibit the growth of a wide range of sensitive and resistant Gram-positive and -negative bacteria, emerging as hopeful candidates to challenge antimicrobial resistance (Raghunath and Perumal, 2017 ; Reshma et al, 2017 ; Kadiyala et al, 2018 ). Iron oxide (Fe 3 O 4 ), Zinc oxide (ZnO), and Copper oxide (CuO) possess antimicrobial properties and can be applied in clinical care (Sinha et al, 2011 ).…”

Section: Metal Oxidesmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.

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Section: Metal Oxidesmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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“…Interestingly, in the present investigation the activity was found against both Gram +ve and Gram −ve pathogens with highest percentage of activity were found against Gram −ve pathogens. Based on the scientific evidence available, it can be confirmed that nanoparticles are reported to be effective antibacterial agents against wide range of test pathogens [38]. The use of nanoparticles can offer best suited alternatives as they can have multiple modes of actions [39].…”

Section: Discussionmentioning

confidence: 99%

Phyto-nano-hybrids of Ag-CuO particles for antibacterial activity against drug-resistant pathogens

Baker

Olga

Tatiana

et al. 2020

Journal of Genetic Engineering and Biotechnology

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Background The present study reports the antibacterial potential of phyto-nano-hybrid particles Ag-CuO (silver-copper oxide) against drug-resistant pathogens isolated from a Russian hospital in Krasnoyarsk, Siberia. The synthesis of nano-hybrid was achieved by phytogenic source by using leaves of Murraya koenigii. The nano-hybrid particles were well characterized using hyphenated techniques and results of the antibacterial assay was tabulated. Results The UV-visible spectra displayed absorption at 420 nm with the shoulder peak at 355 nm indicating the hybridization. The FTIR analysis revealed the presence of phenol, amine, methyl, carbohydrate and aromatic as major functional groups. The XRD analysis revealed the presence of Bragg’s intensities at 2 theta angle depicting the crystalline nature of Ag-CuO nano-hybrid. The TEM analysis displayed the polydispered properties of Ag-CuO nano-hybrid with the size in the range of 60–80 nm exhibiting different shapes ranging from spherical, rod and oval. The antibacterial activity of Ag-CuO nano-hybrid was tested against multidrug-resistant pathogens that resulted in highest activity against P. aeruginosa strain with an inhibition zone of 14 mm in diameter. The MIC concentrations ranged from 0.3125 to 2.5 μg/ml and broth dilution assay displayed dose-dependent properties of Ag-CuO nano-hybrid particles. Conclusion The obtained results are interesting to report the preliminary insight to develop biocompatible hybrid particles to combat drug-resistant pathogens. The developed nano-hybrid particles displayed activity against all the test pathogens investigated against both Gram-positive and Gram-negative bacteria. Thus, the study forms preliminary investigation to report nano-hybrid particles as broad spectrum antibacterial agents.

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“…More importantly, their large surface area provides great opportunity for functionalization. 103 In the modification process using imaging probes such as indocyanine green, the metal oxide nanoparticles are expected to perform fluorescence and photoacoustic imaging modalities that are more attractive than clinically used MRI and nuclear imaging in the price, safety, and operational simplicity. 104,105 Further elaborately finetuning, metal oxide nanoparticles can be readily tailored with bacteria-targeted ligands, implementing a precise signal readout for bacteria detection and imaging.…”

Section: Bacterial Diagnosis Of Metal Oxide Nanoparticlesmentioning

confidence: 99%

Leveraging metal oxide nanoparticles for bacteria tracing and eradicating

Ren

Zhang

et al. 2020

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Rapid emergence of antibiotic resistance facilitates the development of a number of novel‐acting alternatives. Among these emerging approaches, metal oxide nanoparticles receive great attention due to their distinctive performance in antimicrobial stewardship. These nanoparticles can not only target the cell wall, membrane, and cytoplasmic contents to disrupt cellular homeostasis, but can also generate reactive oxygen species highly cytotoxic for virtually all microorganisms without resistance concern. By taking advantage of inherent imaging characteristics and facile surface functionalization with specific imaging moieties, the metal oxide nanoparticles show great promise in the bacterial tracing and eradicating. In this review, we examine a critical analysis of antimicrobial mechanisms, physicochemical characteristics, and modification strategies for metal oxide nanoparticles. The diagnosis of metal oxide nanoparticles for bacterial infections, coupled with their potential for bacterial theranostics, has been highlighted. We anticipate that this review will provide new insights on design and development of advanced metal oxide nanoparticles to manage bacterial infections, particularly those caused by multidrug‐resistant species.

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Antibacterial Metal Oxide Nanoparticles: Challenges in Interpreting the Literature

Cited by 110 publications

References 65 publications

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Phyto-nano-hybrids of Ag-CuO particles for antibacterial activity against drug-resistant pathogens

Leveraging metal oxide nanoparticles for bacteria tracing and eradicating

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