Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107

Song, Qi; Li, Xiaoming; Hu, Xue-Yi; Chi, Liang; Li, Honglei; Wang, Bin‐Gui

doi:10.1016/j.phytol.2019.09.004

Cited by 12 publications

(5 citation statements)

References 12 publications

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“…Besides, it was able to inhibit drug-resistant malaria parasite Plasmodium falciparum with single-digit IC 50 value without obvious cytotoxicity against mammalian cell line. Aminobenzoic peptides 66 and 67 were obtained from Ascidian-derived endophytic fungus Aspergillus clavatus AS-107, demonstrating good anti-bacterial activities against P. aeruginosa with MIC values of 32.7 and 8.8 μg/mL, respectively [ 74 ].…”

Section: Emerging Mnps As Promising Antibiotics For Inhibiting ...mentioning

confidence: 99%

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

Maimaitiming

Zhou

et al. 2022

Marine Drugs

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Pseudomonas aeruginosa, one of the most intractable Gram-negative bacteria, has become a public health threat due to its outer polysaccharide layer, efflux transporter system, and high level of biofilm formation, all of which contribute to multi-drug resistance. Even though it is a pathogen of the highest concern, the status of the antibiotic development pipeline is unsatisfactory. In this review, we summarize marine natural products (MNPs) isolated from marine plants, animals, and microorganisms which possess unique structures and promising antibiotic activities against P. aeruginosa. In the last decade, nearly 80 such MNPs, ranging from polyketides to alkaloids, peptides, and terpenoids, have been discovered. Representative compounds exhibited impressive in vitro anti-P. aeruginosa activities with MIC values in the single-digit nanomolar range and in vivo efficacy in infectious mouse models. For some of the compounds, the preliminary structure-activity-relationship (SAR) and anti-bacterial mechanisms of selected compounds were introduced. Compounds that can disrupt biofilm formation or membrane integrity displayed potent inhibition of multi-resistant clinical P. aeruginosa isolates and could be considered as lead compounds for future development. Challenges on how to translate hits into useful candidates for clinical development are also proposed and discussed.

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Section: Emerging Mnps As Promising Antibiotics For Inhibiting ...mentioning

confidence: 99%

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

Maimaitiming

Zhou

et al. 2022

Marine Drugs

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“…Moreover, cyclodepsipeptide was isolated from the ascidian-derived fungus Aspergillus clavatus AS-107. This compound showed potent antimicrobial activity against P. aeruginosa , with a MIC value of 8.8 µM [ 117 ].…”

Section: Marine Natural Products Against P Aeruginosamentioning

confidence: 99%

Exploring Oceans for Curative Compounds: Potential New Antimicrobial and Anti-Virulence Molecules against Pseudomonas aeruginosa

et al. 2022

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Although several antibiotics are already widely used against a large number of pathogens, the discovery of new antimicrobial compounds with new mechanisms of action is critical today in order to overcome the spreading of antimicrobial resistance among pathogen bacteria. In this regard, marine organisms represent a potential source of a wide diversity of unique secondary metabolites produced as an adaptation strategy to survive in competitive and hostile environments. Among the multidrug-resistant Gram-negative bacteria, Pseudomonas aeruginosa is undoubtedly one of the most important species due to its high intrinsic resistance to different classes of antibiotics on the market and its ability to cause serious therapeutic problems. In the present review, we first discuss the general mechanisms involved in the antibiotic resistance of P. aeruginosa. Subsequently, we list the marine molecules identified up until now showing activity against P. aeruginosa, dividing them according to whether they act as antimicrobial or anti-virulence compounds.

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“…The clavatoic acid derivative (125) exhibited definite bacterial inhibitory activity against M. luteus with an MIC value of 38.1 μM. 55 An indoloditerpene, (3 R ,9 S ,12 R ,13 S ,17 S ,18 S )-2-carbonyl-3-hydroxylemeniveol (126) was isolated from a marine-derived fungus Aspergillus versicolor ZZ761. This indoloditerpene showed antimicrobial activities against Escherichia coli with a MIC value of 20.6 μM.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Recent updates on the bioactive compounds of the marine-derived genusAspergillus

et al. 2021

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Antibacterial metabolites from Ascidian-derived fungus Aspergillus clavatus AS-107

Cited by 12 publications

References 12 publications

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa

Exploring Oceans for Curative Compounds: Potential New Antimicrobial and Anti-Virulence Molecules against Pseudomonas aeruginosa

Recent updates on the bioactive compounds of the marine-derived genusAspergillus

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