Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials

Liu, Jianghua; Wu, Di; Zhu, Niu; Wu, Yongning; Li, Guoliang

doi:10.1016/j.tifs.2021.01.012

Cited by 142 publications

(72 citation statements)

References 154 publications

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“…Bacteria are classified into two groups based on the structure of their cell walls: gram-negative and gram-positive. Gram-negative bacteria have a thinner peptidoglycan layer than gram-positive bacteria because they have a unique outer membrane [ 6 ]. In this work, a gram-negative and a gram-positive bacterium were studied.…”

Section: Introductionmentioning

confidence: 99%

Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties

et al. 2022

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In this study, Cuprous Oxide (Cu2O), known for its mechanism against bacteria, was used as filler to induce biocidal properties on a common commercial resin stereolithography (SLA) 3D printing resin. The aim was to develop nanocomposites suitable for the SLA process with a low-cost process that mimic host defense peptides (HDPs). Such materials have a huge economic and societal influence on the global technological war on illness and exploiting 3D printing characteristics is an additional asset for these materials. Their mechanical performance was also investigated with tensile, flexural, Charpy’s impact, and Vickers microhardness tests. Morphological analysis was performed through scanning electron microscopy (SEM), atomic force microscopy (AFM), and energy-dispersive X-ray spectroscopy (EDS) analysis, while the thermal behavior was studied through Thermogravimetric Analysis (TGA). The antibacterial activity of the fabricated nanocomposites was investigated using a screening agar well diffusion method, for a gram-negative and a gram-positive bacterium. Three-dimensional printed nanocomposites exhibited antibacterial performance in all loadings studied, while their mechanical enhancement was approximately 20% even at low filler loadings, revealing a multi-functional performance and a potential of Cuprous Oxide implementation in SLA resin matrices for engineering and medical applications.

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Section: Introductionmentioning

confidence: 99%

Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties

et al. 2022

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“…As early as 1985, Matsunaga et al, discovered that TiO 2 had a certain photocatalytic sterilization performance under ultraviolet irradiation [ 4 ]. Since then, research on photocatalytic sterilization materials and their sterilization mechanism has been widely reported [ 5 , 6 , 7 ]. In single-phase crystals, the separation rate of the electron-hole is slow and the recombination is easy, which seriously reduces the actual efficiency of the photocatalyst.…”

Section: Introductionmentioning

confidence: 99%

Novel MOF-Based Photocatalyst AgBr/AgCl@ZIF-8 with Enhanced Photocatalytic Degradation and Antibacterial Properties

et al. 2022

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A novel visible light-driven AgBr/AgCl@ZIF-8 catalyst was synthesized by a simple and rapid method. The composition and structure of the photocatalyst were characterized by XRD, SEM, UV-DRS, and XPS. It could be observed that the 2-methylimidazole zinc salt (ZIF-8) exhibited the rhombic dodecahedron morphology with the AgCl and AgBr particles evenly distributed around it. The composite photocatalyst AgBr/AgCl@ZIF-8 showed good photocatalytic degradation and antibacterial properties. The degradation rate of RhB solution was 98%, with 60 min of irradiation of visible light, and almost all P. aeruginosaudomonas aeruginosa (P.aeruginosa), Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli) were inactivated under the irradiation of 90 min. In addition, the prepared catalyst had excellent stability and reusability. Based on the free radical capture experiment, ·O2- and h+ were believed to be the main active substances, and possible photocatalytic degradation and sterilization mechanisms of AgBr/AgCl@ZIF-8 were proposed.

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“…[ 20 ] Compared with traditional large‐scale materials, nanomaterials have unique physical properties (e.g., optical, mechanical, thermal, and electromagnetic) because of their special size, high specific surface area, and biofunctionality (e.g., blood retention, tissue permeability, and bacteria targeting) after modification. [ 21 ] These unique characteristics of nanomaterials greatly reinforce their efficacy and extend the application range of physical antimicrobial approaches, especially in the biomedical field. Moreover, by adjusting its composition and structure, one nanomaterial can respond to a variety of physical stimuli, thus acting as an excellent toolbox to combine and exploit the complementary advantages of multiple physical antimicrobial modalities, enabling better treatment of bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Jia

Wang

et al. 2022

Advanced Science

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The emergence of bacterial resistance due to the evolution of microbes under antibiotic selection pressure, and their ability to form biofilm, has necessitated the development of alternative antimicrobial therapeutics. Physical stimulation, as a powerful antimicrobial method to disrupt microbial structure, has been widely used in food and industrial sterilization. With advances in nanotechnology, nanophysical antimicrobial strategies (NPAS) have provided unprecedented opportunities to treat antibiotic-resistant infections, via a combination of nanomaterials and physical stimulations. In this review, NPAS are categorized according to the modes of their physical stimulation, which include mechanical, optical, magnetic, acoustic, and electrical signals. The biomedical applications of NPAS in combating bacterial infections are systematically introduced, with a focus on their design and antimicrobial mechanisms. Current challenges and further perspectives of NPAS in the clinical treatment of bacterial infections are also summarized and discussed to highlight their potential use in clinical settings. The authors hope that this review will attract more researchers to further advance the promising field of NPAS, and provide new insights for designing powerful strategies to combat bacterial resistance.

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Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials

Cited by 142 publications

References 154 publications

Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties

Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties

Novel MOF-Based Photocatalyst AgBr/AgCl@ZIF-8 with Enhanced Photocatalytic Degradation and Antibacterial Properties

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

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