Antibacterial hydrogel coating by electrophoretic co-deposition of chitosan/alkynyl chitosan

Ding, Fuyuan; Nie, Zhen; Deng, Hongbing; Xiao, Ling; Du, Yumin; Shi, Xiaowen

doi:10.1016/j.carbpol.2013.07.042

Cited by 79 publications

(37 citation statements)

References 37 publications

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“…274 As for the polymers composed mainly of CS, semi-interpenetrating CMCh/poly(acrylonitrile) hydrogels were reported to have clearly better antibacterial activity with more CMCh, and hydrogel coating by electrophoretic co-deposition of CS/alkynyl CS exhibited better antibacterial activities than pure CS hydrogel. 19,275 In the study by Straccia et al, 276 alginate hydrogels coated with CS hydrochloride showed intrinsic antimicrobial activity against E. coli. Quaternary ammonium CS/PVA/polyethylene oxide (PEO) hydrogels were reported to exhibit a pronounced inhibitory effect against S. aureus and E. coli.…”

Section: Antimicrobial Polysaccharidesmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

303

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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Section: Antimicrobial Polysaccharidesmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

303

230

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“…However, given that Ag ions have been proven to be highly toxic, wound healing is often delayed. Thus, modified chitosan or chitosan derivatives and new alginate‐based antibacterial hydrogels dressings have attracted increased research attention …”

Section: Methodsmentioning

confidence: 99%

“…Thus, modified chitosan or chitosan derivatives and new alginate-based antibacterial hydrogels dressings have attracted increased research attention. [9][10][11][12][13] Despite the advancements and the wide range of dressings available, wound management remains extremely challenging because of the susceptibility of a wound to bacterial infection. [14] Especially, diagnosis of bacterial infection is not straightforward and speed of detection is essential in clinical conditions.…”

mentioning

confidence: 99%

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

et al. 2020

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Antibacterial photodynamic therapy (APDT) is an encouraging therapy modality for bacterial infection. In this work, trithiophene aldehyde (3T‐CHO) as a new photosensitizers was isolated from Herba Ecliptae, and tryptophan (Trp) modified 3T‐CHO improve water solubility and reduced phototoxicity. The photosensitizer‐loaded vesicles were incorporated into a gel scaffold to obtain a wound dressing with detection and antibacterial function. Detection of the presence of pathogenic bacteria, such as Pseudomonas aeruginosa, based on the fluorescence signals was highly efficient and sensitive. The cytotoxin produced by the pathogenic bacteria to induce vesicle lysis, thereby the photosensitive antibacterial agent was released from the vesicle to realize the simultaneous intelligent detection and treatment of pathogenic bacteria. Compared with traditional dressings coated with antibiotics, the synthesized dressing avoids the drawback of pathogenic bacteria developing drug resistance. The proposed microbiologically responsive wound dressing could be used as a general methodology for the design and fabrication of bacterium‐responsive functional biomaterials.

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“…In the last decade, polymer coatings with antibacterial activities have attracted great interest in the biomedical field due to their ability to reduce implant-associated infections [16]. Chitosan, in particular, is one of the most promising natural biopolymers for tissue engineering [17].…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition and Characterisation of Chitosan Coatings on Near-Β Titanium Alloy

Jugowiec¹,

Kot²,

Moskalewicz³

2016

Archives of Metallurgy and Materials

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In this study, chitosan coatings were electrophoretically deposited (EPD) on near-β Ti-13Nb-13Zr alloy. The influence of colloidal solution composition and EPD parameters on the quality of chitosan coatings was investigated. It was established that the uniformity of as-deposited chitosan coatings is highly dependent on the chemical composition of the solution used for EPD, the pH, electrophoretic mobility and zeta potential of chitosan colloidal molecules, as well as EPD parameters, such as potential difference value and deposition time. The microstructure of the coatings was investigated using electron microscopy and X-ray diffractometry. The coatings 350 nm thick were homogeneous and exhibited an amorphous structure. The coatings had low hardness and Young’s modulus. The effect of surface of the substrate preparation prior to coating deposition on the adhesion of chitosan coatings to the Ti-13Nb-13Zr alloy was also investigated. The coatings exhibited good adhesion to the non-acid-etched surface of the titanium alloy.

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Antibacterial hydrogel coating by electrophoretic co-deposition of chitosan/alkynyl chitosan

Cited by 79 publications

References 37 publications

Antimicrobial hydrogels: promising materials for medical application

Antimicrobial hydrogels: promising materials for medical application

Development of an Intelligent Photosensitive Antibacterial Wound Dressing: Simultaneous Detection and Treatment of Bacterial Infection for Accelerated Wound Healing

Electrophoretic Deposition and Characterisation of Chitosan Coatings on Near-Β Titanium Alloy

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