Antibacterial hyaluronic acid/chitosan multilayers onto smooth and micropatterned titanium surfaces

Valverde, Ainara; Pérez‐Álvarez, Leyre; Ruiz‐Rubio, Leire; Olivenza, Miguel Angel Pacha; García-Blanco, María Belén; Díaz-Fuentes, M.; Vilas, José Luis

doi:10.1016/j.carbpol.2018.12.039

Cited by 65 publications

(40 citation statements)

References 41 publications

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“…For that purpose, the coatings can be created using hydrogels or ceramics, which possess a larger pore size and specific morphological structures, or employ nanostructured polymeric systems such as, polyelectrolyte multilayers (PEM). These last can be built in a simple, versatile and low-cost way, growing alternating layers of opposite charges by dip-coating [90,91] or spray-coating, [92] based on the LbL technique. The most widely used released-based antibacterial surfaces and their examples are explained in Table 2.…”

Section: Release-based Antibacterial Surfacesmentioning

confidence: 99%

“…Triclosan Cyclodextrin [103] Hyaluronic acid and chitosan [90] Poly(ethylene terephthalate) [104] Polyacrilonitrile [105] Chlorhexidrine Acrylic bone cements [106] Furanones Polyethylene, polypropylene [107] Nitrogen oxide Silica nanoparticles [108] Vancomyzin Poly(ethylene glycol) (PEG)-acrylate [109] Tobramycin Hydroxyapatite [110] Tetracycline hydrochloride Hydroxyapatite and polycaprolactone [111] Octenidine Poly(L-lactide) [112] Cationic surfactants Poly(methyl methacrylate) [113] Acylase enzyme Polydimethyl/vinylmethyl-siloxane [114] Lysozyme enzyme Cellulose [115] Halogens Titanium [116] Antibiotics Penicillins Quinilones Aminoglycosides [117] Apart from laboratory-scale products, there are commercially available products in the medical field based on antibacterial coatings with release capacity. For instance, Innovotech ® developed novel antibacterial medical devices called InnovoSIL TM Antimicrobial Products incorporating innovative and effective antimicrobial agents in them.…”

Section: Released Antimicrobial Substance Release Systems Referencesmentioning

confidence: 99%

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Antibacterial Coatings for Improving the Performance of Biomaterials

et al. 2020

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Biomedical devices have become essential in the health care. Every day, an enormous number of these devices are used or implanted in humans. In this context, the bacterial contamination that could be developed in implanted devices is critical since it is estimated that infections kill more people than other medical causes. Commonly, these infections are treated with antibiotics, but the biofilm formation on implant surfaces could significantly reduce the effectiveness of these antibiotics since bacteria inside the biofilm is protected from the drug. In some cases, a complete removal of the implant is necessary in order to overcome the infection. In this context, antibacterial coatings are considered an excellent strategy to avoid biofilm formation and, therefore, mitigate the derived complications. In this review, the main biomaterials used in biomedical devices, the mechanism of biofilm formation, and the main strategies for the development of antibacterial coatings, are reviewed. Finally, the main polymer-based strategies to develop antibacterial coatings are summarized, with the aim of these coatings being to avoid the bacteria proliferation by controlling the antibacterial mechanisms involved and enhancing long-term stability.

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Section: Release-based Antibacterial Surfacesmentioning

confidence: 99%

Section: Released Antimicrobial Substance Release Systems Referencesmentioning

confidence: 99%

Antibacterial Coatings for Improving the Performance of Biomaterials

et al. 2020

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“…Hyaluronic acid and chitosan can form nanoparticles, hydrogels, microspheres, sponges, and films, all with a wide range of biomedical applications. In the scientific literature, there are several papers regarding an investigation of interactions between chitosan and HA [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Blends Of Hyaluronic Acid and Chitosanmentioning

confidence: 99%

“…It was stated that the carboxyl group in hyaluronic acid can form the hydrogen bonds with the protonated amine in chitosan, which promotes the increase in mechanical strength of the hydrogels and depresses the initial burst release of drugs from the hydrogel. Hyaluronic acid/chitosan polyelectrolyte multilayers were used for surface modification of titanium alloys for biomedical applications [ 52 ]. Hyaluronic acid and chitosan-based materials can also be used as a new dressing generation for wound care [ 53 ].…”

Section: Blends Of Hyaluronic Acid and Chitosanmentioning

confidence: 99%

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

et al. 2020

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In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

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“…Palla-Rubio et al incorporated silica-chitosan hybrid materials onto titanium implants to improve the antibacterial activity and found that the suitable concentration of 5%-10% for contained chitosan showed antibacterial properties [170]. Also, the antibacterial properties of hyaluronic acid/chitosan polyelectrolyte multilayers against Staphylococcus aureus were approved [171].…”

Section: Polysaccharide Antibacterial Coatingsmentioning

confidence: 99%

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

et al. 2020

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Dental implants are widely used in the field of oral restoration, but there are still problems leading to implant failures in clinical application, such as failed osseointegration, marginal bone resorption, and peri-implantitis, which restrict the success rate of dental implants and patient satisfaction. Poor osseointegration and bacterial infection are the most essential reasons resulting in implant failure. To improve the clinical outcomes of implants, many scholars devoted to modifying the surface of implants, especially to preparing different physical and chemical modifications to improve the osseointegration between alveolar bone and implant surface. Besides, the bioactive-coatings to promote the adhesion and colonization of ossteointegration-related proteins and cells also aim to improve the osseointegration. Meanwhile, improving the anti-bacterial performance of the implant surface can obstruct the adhesion and activity of bacteria, avoiding the occurrence of inflammation related to implants. Therefore, this review comprehensively investigates and summarizes the modifying or coating methods of implant surfaces, and analyzes the ossteointegration ability and anti-bacterial characteristics of emerging functional coatings in published references.

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Antibacterial hyaluronic acid/chitosan multilayers onto smooth and micropatterned titanium surfaces

Cited by 65 publications

References 41 publications

Antibacterial Coatings for Improving the Performance of Biomaterials

Antibacterial Coatings for Improving the Performance of Biomaterials

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

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