Antibacterial honey for the prevention of peritoneal-dialysis-related infections (HONEYPOT): a randomised trial

Johnson, David W.; Badve, Sunil V.; Pascoe, Elaine M.; Beller, Elaine; Cass, Alan; Clark, Carolyn; Zoysa, Janak de; Isbel, Nicole M.; McTaggart, Steven; Morrish, Alicia T.; Playford, E Geoffrey; Scaria, Anish; Snelling, Paul; Vergara, Liza A.; Hawley, Carmel M.

doi:10.1016/s1473-3099(13)70258-5

Cited by 78 publications

(58 citation statements)

References 28 publications

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“…161,[180][181][182][183][184][185] Although this reduction has been most apparent for Grampositive infections, significant reductions have also been reported for Gram-negative peritonitis. [194][195][196][197][198][199] Despite these improvements, there remains a wide and unacceptable variation in reported rates from different countries, ranging from 0.06 episodes/ year in Taiwan to 1.66 episodes/year in Israel. 180,[186][187][188][189][190][191][192][193] Within Australia, country-wide PD-related peritonitis rates fell significantly by 37% over a 5-year period from 0.62 episodes per patient-year in 2008 to 0.39 episodes per patient-year in 2013 after a concerted, multidisciplinary and multipronged national peritonitis reduction campaign involving quarterly audit and feedback of individual unit peritonitis rates, prioritization of peritonitis prevention trials by the Australasian Kidney Trials Network, updating national clinical practice guidelines on peritonitis, launching peritonitis guideline implementation projects, publishing of a call to action paper, establishment of a PD Academy to provide PD training to junior nephrologists and nursing staff, and development of a Home Dialysis Network to support home dialysis patients (http:// homedialysis.org.au/).…”

Section: Peritonitismentioning

confidence: 99%

The Current State of Peritoneal Dialysis

Mehrotra

Devuyst

Davies

et al. 2016

JASN

401

344

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Technical innovations in peritoneal dialysis (PD), now used widely for the long-term treatment of ESRD, have significantly reduced therapy-related complications, allowing patients to be maintained on PD for longer periods. Indeed, the survival rate for patients treated with PD is now equivalent to that with in-center hemodialysis. In parallel, changes in public policy have spurred an unprecedented expansion in the use of PD in many parts of the world. Meanwhile, our improved understanding of the molecular mechanisms involved in solute and water transport across the peritoneum and of the pathobiology of structural and functional changes in the peritoneum with long-term PD has provided new targets for improving efficiency and for intervention. As with hemodialysis, almost half of all deaths on PD occur because of cardiovascular events, and there is great interest in identifying modality-specific factors contributing to these events. Notably, tremendous progress has been made in developing interventions that substantially reduce the risk of PD-related peritonitis. Yet the gains have been unequal among individual centers, primarily because of unequal clinical application of knowledge gained from research. The work to date has further highlighted the areas in need of innovation as we continue to strive to improve the health and outcomes of patients treated with PD.

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Section: Peritonitismentioning

confidence: 99%

The Current State of Peritoneal Dialysis

Mehrotra

Devuyst

Davies

et al. 2016

JASN

401

344

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“…Adaptive, Sequential, Multiple Assignment, Randomized Trials, and enriched trial designs may reduce the number of patients required for an individual study. These designs have been reviewed in recent publications (21)(22)(23)(24).…”

Section: Study Design and Proceduresmentioning

confidence: 99%

Optimizing Enrollment of Patients into Nephrology Research Studies

Selewski

Herreshoff

Gipson

2016

Clinical Journal of the American Society of Nephrology

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Advances in medical care and biomedical research depend on the participation of human subjects. Poor patient enrollment in research has limited past clinical and translational research endeavors in nephrology. Simultaneously, patients and their caregivers are seeking better diagnostic, monitoring, and therapeutic approaches to improve or restore kidney and overall health. This manuscript will discuss a framework and strategies to optimize patient enrollment within nephrology research and provide examples of success from existing nephrology research programs.

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“…Por ser tan multifactorial, se han planteado múltiples estrategias preventivas como soporte principal al desarrollo de los episodios de peritonitis [37][38][39][40][41][42][43][44][45] .…”

Section: Introductionunclassified

Microbiological evaluation safety cap in peritoneal dialysis

García¹,

Silva²,

Herrera³

et al. 2015

Rev. Colomb. Nefrol.

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ResumenEn los pacientes con enfermedad renal crónica terminal, que reciben terapia dialítica bajo la modalidad de diálisis peritoneal, se ha descrito que las complicaciones infecciosas como la peritonitis, permanecen como la principal causa de pérdida de la terapia, aún después de lograr disminuir las tasas de presentación de esta complicación. Los factores etiológicos asociados son múltiples y van desde la condición clínica del paciente, su adherencia al protocolo de realización de la terapia, su estado socioeconómico y el sistema utilizado para el aporte de los líquidos al peritoneo. Tomando como objetivo estos factores, decidimos estudiar la adherencia al protocolo de conexión de diálisis,el comportamiento microbiológico y su asociación altapón de seguridad del cambio anterior del sistema de diálisis peritoneal BenY®, en pacientes previamente clasificados según su adherencia al protocolo de conexión a diálisis. Se evaluó la técnica del paciente para la conexión a su terapia según la escala de 9 pasos fundamentales y puntos adicionales, y se tomaron cultivos de dispositivos nuevos y usados por los pacientes. En nuestro estudio no se evidenció asociación clínicamente significativa del dispositivo evaluado en el desarrollo de peritonitis, comparado con otros existentes para la misma finalidad. Palabras clave: Diálisis peritoneal, peritonitis, tapón de seguridad del cambio anterior (fuente DeCS). Microbiological evaluation safety cap in peritoneal dialysis AbstractIn patients with end stage renal disease treated with peritoneal dialysis, peritonitis remain as a principal cause of complications and loss patient for this therapy, instead of the decrease in peritonitis rate. Etiology has been related to multiple factors included clinical conditions of patient, follow of a clinical protocol for connection to dialysis, its socioeconomic status and the used system to deliver fluid to peritoneal cavity. Considering that, in this study we evaluated the microbiological behavior of "Sistema de diálisis peritoneal BenY´s® "Safety Lock", and its contribution to peritonitis develop, in evaluated patient for adherence to the clinical protocol for connection to peritoneal dialysis. Patient connection technique, was assessed by nine key steps, and then took cultures of new and used devices by patients. In our study there is no evidence of a clinical correlation of evaluated device with infectious episodes.

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Antibacterial honey for the prevention of peritoneal-dialysis-related infections (HONEYPOT): a randomised trial

Cited by 78 publications

References 28 publications

The Current State of Peritoneal Dialysis

The Current State of Peritoneal Dialysis

Optimizing Enrollment of Patients into Nephrology Research Studies

Microbiological evaluation safety cap in peritoneal dialysis

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