Antibacterial gauze based on the synergistic antibacterial mechanism of antimicrobial peptides and silver nanoparticles

Chen, Li; Ai, Jianyang; Cai, Haihua; Chen, Xiang; Liu, Zulan; Li, Zhi; Dai, Fangyin

doi:10.1007/s10965-020-02363-3

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…Various combinations of cationic AMPs with other peptides and conventional antibiotics allow broadening of bacteriostatic and bactericidal performance of traditional antimicrobials and simultaneously lower the possibility of resistance genesis. Reduced cytotoxicity of inorganic phase and enhanced performance against both Gm+ and Gm− germs make these composite potential candidates in practical application, like wound healing and wound care [ 251 , 252 , 253 ]. Engineering of AgNPs-based composites with AMPs has been reported by several groups within the last decades.…”

Section: Silver-based Composites With Synergistic Antimicrobial Activity: Organic Parts Of the Composite With Intrinsic Am Actionmentioning

confidence: 99%

Ag-Based Synergistic Antimicrobial Composites. A Critical Review

et al. 2021

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The emerging problem of the antibiotic resistance development and the consequences that the health, food and other sectors face stimulate researchers to find safe and effective alternative methods to fight antimicrobial resistance (AMR) and biofilm formation. One of the most promising and efficient groups of materials known for robust antimicrobial performance is noble metal nanoparticles. Notably, silver nanoparticles (AgNPs) have been already widely investigated and applied as antimicrobial agents. However, it has been proposed to create synergistic composites, because pathogens can find their way to develop resistance against metal nanophases; therefore, it could be important to strengthen and secure their antipathogen potency. These complex materials are comprised of individual components with intrinsic antimicrobial action against a wide range of pathogens. One part consists of inorganic AgNPs, and the other, of active organic molecules with pronounced germicidal effects: both phases complement each other, and the effect might just be the sum of the individual effects, or it can be reinforced by the simultaneous application. Many organic molecules have been proposed as potential candidates and successfully united with inorganic counterparts: polysaccharides, with chitosan being the most used component; phenols and organic acids; and peptides and other agents of animal and synthetic origin. In this review, we overview the available literature and critically discuss the findings, including the mechanisms of action, efficacy and application of the silver-based synergistic antimicrobial composites. Hence, we provide a structured summary of the current state of the research direction and give an opinion on perspectives on the development of hybrid Ag-based nanoantimicrobials (NAMs).

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Section: Silver-based Composites With Synergistic Antimicrobial Activity: Organic Parts Of the Composite With Intrinsic Am Actionmentioning

confidence: 99%

Ag-Based Synergistic Antimicrobial Composites. A Critical Review

et al. 2021

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“…In our daily life, how to effectively combat skin wound infection is a problem that we often face. The antimicrobial components that are commonly used in anti-wound skin infection strategies include antibiotics [ 1 ], antimicrobial peptides [ 2 , 3 ], and silver-containing compound nanomaterials [ 4 , 5 , 6 , 7 ]. The long-term use of these drugs, especially antibiotics, easily causes bacterial resistance.…”

Section: Introductionmentioning

confidence: 99%

Construction and Activity Study of a Natural Antibacterial Patch Based on Natural Active Substance-Green Porous Structures

Gao

Zhou

et al. 2023

Molecules

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Bacterial infections are a serious threat to human health, and the rapid emergence of bacterial resistance caused by the abuse of antibiotics exacerbates the seriousness of this problem. Effectively utilizing natural products to construct new antimicrobial strategies is regarded as a promising way to suppress the rapid development of bacterial resistance. In this paper, we fabricated a new type of natural antibacterial patch by using a natural active substance (allicin) as an antibacterial agent and the porous structure of the white pulp of pomelo peel as a scaffold. The antibacterial activity and mechanisms were systematically investigated by using various technologies, including the bacteriostatic circle, plate counting, fluorescence staining, and a scanning electron microscope. Both gram-positive and negative bacteria can be effectively killed by this patch. Moreover, this natural antibacterial patch also showed significant anti-skin infection activity. This study provides a green approach for constructing efficient antibacterial patches.

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“…Unfortunately, without injectability, insufficient coating may occur on the irregular shaped wounds with NexoBrid®. Besides, gauze ( Fang et al, 2021 ; Chen et al, 2021a ; Said et al, 2021 ), electrospun nanofiber ( Lutfi et al, 2021 ; Shahrousvand et al, 2021 ; Zhu et al, 2021 ), porous foam ( Wang et al, 2008 ; Staruch et al, 2017 ), biocompatible membrane ( Huang et al, 2021 ), microfibers ( Zhao et al, 2015 ; Yu et al, 2017 ), and hydrogels ( Soriano et al, 2020 ; Yuan et al, 2021 ; Kopecki, 2021 ) can be used as burn wound dressings today. However, most of them cannot display critical properties such as exudates which are absorbing and moisture-maintaining at the same time compared with hydrogel dressings ( Gou and Ma, 2018 ; Zhao et al, 2018 ; Gobhril and Grinstaff, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

A Sequential Therapeutic Hydrogel With Injectability and Antibacterial Activity for Deep Burn Wounds’ Cleaning and Healing

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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As a severe clinical challenge, escharotomy and infection are always the core concerns of deep burn injuries. However, a usual dressing without multifunctionality leads to intractable treatment on deep burn wounds. Herein, we fabricated a sequential therapeutic hydrogel to solve this problem. Cross-linked by modified polyvinyl alcohol (PVA-SH/ε-PL) and benzaldehyde-terminated F127 triblock copolymers (PF127-CHO), the hydrogel demonstrated excellent mechanical properties, injectability, tissue adhesiveness, antibacterial activity, biocompatibility, and satisfactory wound cleaning through both in vitro and in vivo assays. Additionally, based on the conception of “sequential therapy,” we proposed for the first time to load bromelain and EGF into the same hydrogel in stages for wound cleaning and healing. This work provides a strategy to fabricate a promising wound dressing for the treatment of deep burn wounds with injectability and improved patients’ compliance as it simplified the process of treatment due to its “three in one” characteristic (antibacterial activity, wound cleaning, and healing effects); therefore, it has great potential in wound dressing development and clinical application.

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Antibacterial gauze based on the synergistic antibacterial mechanism of antimicrobial peptides and silver nanoparticles

Cited by 9 publications

References 18 publications

Ag-Based Synergistic Antimicrobial Composites. A Critical Review

Ag-Based Synergistic Antimicrobial Composites. A Critical Review

Construction and Activity Study of a Natural Antibacterial Patch Based on Natural Active Substance-Green Porous Structures

A Sequential Therapeutic Hydrogel With Injectability and Antibacterial Activity for Deep Burn Wounds’ Cleaning and Healing

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