Antibacterial Fluorinated Silica Colloid Superhydrophobic Surfaces

Privett, Benjamin J.; Youn, Jonghae; Hong, Sung A; Lee, Jiyeon; Han, Junhee; Shin, Jae Ho; Schoenfisch, Mark H.

doi:10.1021/la201801e

Cited by 295 publications

(202 citation statements)

References 26 publications

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“…另一方面, 细菌在表面形成生物膜时都先通过范德华力、静电作用力或酸碱反应等粘附在表面, 再分泌基质并生长分化 [15] . 超疏水表面由于粗糙凹槽内存在截留空气, 可以减少细菌与表面的接触面积, 有望阻止细菌在表面第一步的粘附, 从而在一定程度上抑制生物膜的形成 [16] . 尼龙(聚酰胺)具有很好的强度和韧性, 是一类重要的商业化合成高分子.…”

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Superhydrophobic and Highly Oleophobic Nylon Surface

Wei¹,

Zhengzhong²

2014

Acta Chim. Sinica

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Superhydrophobic and superoleophobic surfaces are desirable for many practical applications. Creating a rough structure on polymer surface then modified by materials with low surface free energy can broaden the potential applications of polymers. In this research, we used three different methods to modify nylon 6 surface, then compared their effect on preparing nylon 6 surface roughness. Activation of amides by chemical reduction with borane-THF complex resulted in secondary amine groups, which could absorb silica spheres with different sizes driven by electrostatic attraction. On the other side, alkylation with (3-glycidoxypropyl) triethoxysilane (GPTES) was utilized to introduce silica-like reactivity to the surface, while plasma-treatment could import hydroxyl groups on nylon 6 surface. Then silica layer was generated and covalently bonded to the nylon 6 in situ. After treated with 3-aminopropyl-triethoxysiloxane (APS), silica spheres could be introduced to the sample more evenly than the first method, and then reacted with silicon tetrachloride to enhance mechanical robustness. Plasma-treatment was more fast and clean in preparing the stable roughness, which made this modification a favorable method. Different size silica spheres were used to construct roughness on nylon textile. After being modified with a perfluoroalkyl silane, the surface with all roughness had superhydrophobic property, while the wettability of low-energy liquid on the surface was depending on the micro structure size. Silica spheres with size between 500 nm and 900 nm were propitious to achieve stable Cassie state, which could cause high contact angles (about 140°) and low roll-off angles (about 20°) for 3 μL hexadecane droplets. On the other hand, for the samples adsorbed silica spheres with size between 20 nm and 200 nm, the contact angles and roll-off angles for 3 μL hexadecane were about 125° and 40°, respectively. Because of the air trapped between the roughnesses, the obtained superhydrophobic and highly oleophobic nylon textile also show high resistance to bacterial contamination. This may broaden the application of nylon.

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Superhydrophobic and Highly Oleophobic Nylon Surface

Wei¹,

Zhengzhong²

2014

Acta Chim. Sinica

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“…However, long-term usage of antibiotics risks selecting for resistance among pathogens (41,52). Other materials that also demonstrated antibiofilm function when used to coat biomaterial surfaces include heavy metal ions (48,85), furanone (6,43), hydrophilic polyethylene glycol (PEG) derivatives (38), zwitterionic polymers (15), superhydrophobic coatings synthesized from a mixture of nanostructured silica colloids and a low-surface-energy fluorinated silane xerogel (71), and antimicrobial quaternary ammonium groups fixed to solid surfaces by silane coupling agents (103). Covalently coupled quaternary ammonium silane coatings on silicone rubber yielded a positively charged, highly adhesive surface with antimicrobial effects on adherent Gram-positive and Gram-negative bacteria (33).…”

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confidence: 99%

Inhibition of Staphylococcus epidermidis Biofilm by Trimethylsilane Plasma Coating

Chen

Jones

et al. 2012

Antimicrob Agents Chemother

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c Biofilm formation on implantable medical devices is a major impediment to the treatment of nosocomial infections and promotes local progressive tissue destruction. Staphylococcus epidermidis infections are the leading cause of biofilm formation on indwelling devices. Bacteria in biofilms are highly resistant to antibiotic treatment, which in combination with the increasing prevalence of antibiotic resistance among human pathogens further complicates treatment of biofilm-related device infections. We have developed a novel plasma coating technology. Trimethylsilane (TMS) was used as a monomer to coat the surfaces of 316L stainless steel and grade 5 titanium alloy, which are widely used in implantable medical devices. The results of biofilm assays demonstrated that this TMS coating markedly decreased S. epidermidis biofilm formation by inhibiting the attachment of bacterial cells to the TMS-coated surfaces during the early phase of biofilm development. We also discovered that bacterial cells on the TMS-coated surfaces were more susceptible to antibiotic treatment than their counterparts in biofilms on uncoated surfaces. These findings suggested that TMS coating could result in a surface that is resistant to biofilm development and also in a bacterial community that is more sensitive to antibiotic therapy than typical biofilms.

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“…Schoenfisch 等 [98] 合成了无毒的、有利于环保的超疏水性凝胶涂层, 并证明了该涂层很大程度上降低了金黄色葡萄球菌和绿脓杆菌的粘附. 虽然一些文献已经实现了超疏水性表面的抗菌能力, 但是由于这种表面主要通过降低细菌粘附来实现抗菌, 从而导致其抗菌性能差强人意.…”

Section: 提高血液相容性unclassified