Antibacterial features of material surface: strong enough to serve as antibiotics?

Abstract

Bacteria are small but need big efforts to control. The use of antibiotics not only produces superbugs that are increasingly difficult to inactivate, but also raises environmental concerns with the...

Effect of soft denture liners on complete denture treatments: A systematic review

“…Microbial contamination of denture relines is affected by the following factors: denture material and surface properties [78][79][80][81], properties of relining materials [14,17,20], adhesion of relining materials to the denture base [14], denture cleaning conditions [82], and subject-dependent factors [83]. The surface of the SDR material deteriorates over time, and the silicone-based SDR material delaminates from the adhesive bond with the denture base resin.…”

Virus-like particles nanoreactors: from catalysis towards bio-applications

“…106 VLPs can enrich substrates within the cavity, restrain the random diffusion of intermediates, and reduce unnecessary interference from the bulk solution, resulting in enhanced intermolecular communication. 29 In addition, the enclosed enzymes benefit from better stability due to the constrained environment with reduced denaturation entropy. 115,118 The challenges of replicating the intracellular multienzyme cascade pathway in confined VLPs include colocalizing of distinct enzymes with designed stoichiometry and co-assembling diverse enzymes at specific distances to regulate the diffusion kinetics between active sites.…”

“…120 However, it is important to note that merely colocalization of multiple heterologous enzymes does not This journal is © The Royal Society of Chemistry 2023 guarantee an increase in catalytic activity; instead, it is essential to ensure sufficient substrate channeling to boost the overall catalytic rate. 29 Moreover, excessive enzyme packing within the capsid could lead to overcrowding, potentially causing a decline in catalytic activity. For instance, McNeale et al constructed a tunable strategy for in vivo co-localization of enzymes within P22 VLPs with stoichiometric control.…”

“…For other protein cage-based nanoreactors, 14,15 such as ferritin, [16][17][18][19] Lumazine synthetase (AaLS), [20][21][22] Encapsulins, 23,24 and de novo protein designs et al, 25 we direct readers to recently reported review articles. [26][27][28][29] Over the decades, VLPs-based nanoreactors have undergone significant advancements. VLPs are now recognized as versatile platforms that not only protect catalysts but also enable selective catalysis.…”

Reengineering of an artificial protein cage for efficient packaging of active enzymes

“…[2] These naturally occurring protein cages have inspired the design of smart nanocarriers and nanoreactors with prospective applications in molecular delivery and catalysis. [3]…”