Antibacterial efficacy from NO-releasing MOF–polymer films

Duncan, Morven J.; Wheatley, Paul; Coghill, Emma M; Vornholt, Simon M.; Warrender, Stewart J.; Megson, Ian L.; Morris, Russell E.

doi:10.1039/d0ma00650e

Cited by 19 publications

(35 citation statements)

References 54 publications

(52 reference statements)

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“…Despite the NO release differences, all materials display significant, high NO release levels that are suitable to trigger a biological response (pM–μM) [22,42] . While MOFs have been discussed as NO carriers for medical applications, [22,23,60] a mechanistic study of NO adsorption onto CPO‐27‐Ni framework has not yet been reported. In this study we performed in situ gas cell experiments on vi using synchrotron radiation.…”

Section: Resultsmentioning

confidence: 99%

“…Despite its toxicity, NO has gained much attention in recent years as a potential therapeutic agent, which can display potent antimicrobial, [23,24] vasodilatory, [22,40,41] and wound healing effects when administered within an appropriately low concentration threshold [22,40,41] . The ability to harness the beneficial effects of NO rely on local administration in controlled concentration thresholds; however, due to its gaseous nature and reactivity with oxygen this has proved difficult [16,22,23,42] . MOFs have been investigated as NO delivery agents due to their ability of controlled gas storage and release, [42,43] however in order to fully understand this process, a mechanistic study is needed.…”

Section: Introductionmentioning

confidence: 99%

“…The almost infinite combination of various linkers and metal clusters unlocks a range of functionalities in these frameworks. Porosity paired with functionality opens a wide field of potential applications for MOFs, including battery materials, [3–5] catalysis, [6–9] gas separation [10–14] and storage, [15–19] as well as biomedical applications [20–24] . The majority of these applications rely on guest‐host interactions.…”

Section: Introductionmentioning

confidence: 99%

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Controlled Synthesis of Large Single Crystals of Metal‐Organic Framework CPO‐27‐Ni Prepared by a Modulation Approach: In situ Single‐Crystal X‐ray Diffraction Studies

Vornholt

Elliott

Rice

et al. 2021

Chemistry A European J

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The size of single crystals of the metal‐organic framework CPO‐27‐Ni was incrementally increased through a series of modulated syntheses. A novel linker modulated synthesis using 2,5‐dihydroxyterephthalic acid and the isomeric ligand 4,6‐dihydroxyisophthalic acid yielded large single crystals of CPO‐27‐Ni (∼70 μm). All materials were shown to have high crystallinity and phase purity through powder X‐ray diffraction, electron microscopy methods, thermogravimetry, and compositional analysis. For the first time single‐crystal structure analyses were carried out on CPO‐27‐Ni. High BET surface areas and nitric oxide (NO) release efficiencies were recorded for all materials. Large single crystals of CPO‐27‐Ni showed a prolonged NO release and proved suitable for in situ single‐crystal diffraction experiments to follow the NO adsorption. An efficient activation protocol was developed, leading to a dehydrated structure after just 4 h, which subsequently was NO‐loaded, leading to a first NO loaded single‐crystal structural model of CPO‐27‐Ni.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Controlled Synthesis of Large Single Crystals of Metal‐Organic Framework CPO‐27‐Ni Prepared by a Modulation Approach: In situ Single‐Crystal X‐ray Diffraction Studies

Vornholt

Elliott

Rice

et al. 2021

Chemistry A European J

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“…In particular, combating MDR bacteria such as methicillinresistant Staphylococcus aureus (S. aureus) (MRSA) has drawn wide attention and efforts [2,3]. Non-antibiotic antimicrobial agents such as AMPs [4][5][6], silver nanoparticles (AgNPs) [7][8][9], metal oxides [10][11][12], antimicrobial peptoids [13,14] and polymers [15][16][17][18] are alternatives for treating infectious diseases that kill bacteria in a physical manner and avoid the generation of drug resistance. For instance, cationic compounds including AMPs, antimicrobial peptoids and polymers, as well as their corresponding nanostructures, strongly interacted with the negatively charged cell membrane of bacteria, resulting in the disruption of the cell membrane and outflow of the content of bacteria [19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Metal (oxide) nanoparticles such as widely studied AgNPs kill bacteria via heavy metal ions induced by the denaturation of proteins or genetic materials, while ZnO and TiO 2 nanoparticles eliminate bacteria by reacting with reactive oxygen species (ROS) generated from photocatalytic process [12,21]. Moreover, emerging antimicrobial agents including gases, photothermal sensitizers and carbon materials were also developed to combat bacterial infections [17,[22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

Yin

Sun

2021

Pharmaceutics

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Bacterial infections have threatened the lives of human beings for thousands of years either as major diseases or complications. The elimination of bacterial infections has always occupied a pivotal position in our history. For a long period of time, people were devoted to finding natural antimicrobial agents such as antimicrobial peptides (AMPs), antibiotics and silver ions or synthetic active antimicrobial substances including antimicrobial peptoids, metal oxides and polymers to combat bacterial infections. However, with the emergence of multidrug resistance (MDR), bacterial infection has become one of the most urgent problems worldwide. The efficient delivery of antimicrobial agents to the site of infection precisely is a promising strategy for reducing bacterial resistance. Polymeric nanomaterials have been widely studied as carriers for constructing antimicrobial agent delivery systems and have shown advantages including high biocompatibility, sustained release, targeting and improved bioavailability. In this review, we will highlight recent advances in highly efficient delivery of antimicrobial agents by polymeric nanomaterials such as micelles, vesicles, dendrimers, nanogels, nanofibers and so forth. The biomedical applications of polymeric nanomaterial-based delivery systems in combating MDR bacteria, anti-biofilms, wound healing, tissue engineering and anticancer are demonstrated. Moreover, conclusions and future perspectives are also proposed.

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Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Wang,

Walden,

Ettlinger

et al. 2023

Adv Funct Materials

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Metal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural and compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity to retain organic (drug) molecules, metals, and gases, to effectively channel electrons and photons, to survive harsh physiological conditions such as low pH, and even to protect sensitive biomolecules. Extensive preclinical research has been carried out with MOFs to treat several pathologies and, recently, their integration with other biomedical materials such as stents and implants has demonstrated promising performance in regenerative medicine. However, there remains a significant gap between MOF preclinical research and translation into clinically and societally relevant medicinal products. Here, the intrinsic features of MOFs are outlined and their suitability to specific biomedical applications such as detoxification, drug and gas delivery, or as (combination) therapy platforms is discussed. Furthermore, relevant examples of how MOFs have been engineered and evaluated in different medical indications, including cancer, microbial, and inflammatory diseases is described. Finally, the challenges facing their translation into the clinic are critically examined, with the goal of establishing promising research directions and more realistic approaches that can bridge the translational gap of MOFs and MOF‐containing (nano)materials.

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Antibacterial efficacy from NO-releasing MOF–polymer films

Abstract: Sufficient concentration of nitric oxide is released from metal organic framework loaded polymer films to impart antibacterial efficacy.

Cited by 19 publications

References 54 publications

Controlled Synthesis of Large Single Crystals of Metal‐Organic Framework CPO‐27‐Ni Prepared by a Modulation Approach: In situ Single‐Crystal X‐ray Diffraction Studies

Controlled Synthesis of Large Single Crystals of Metal‐Organic Framework CPO‐27‐Ni Prepared by a Modulation Approach: In situ Single‐Crystal X‐ray Diffraction Studies

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

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