Antibacterial effects of silver-doped hydroxyapatite thin films sputter deposited on titanium

Strontium-substituted hydroxyapatite coatings deposited via a co-deposition sputter technique

“…In addition to this trace amounts of elements such as strontium, barium, copper, zinc, and iron are commonly associated with biological apatite and may be seen as substituents in the apatite structure [2]. Therefore, one approach to control the osteoblastic response of HA coatings, both in vitro and in vivo, could involve the use of substituted HA, incorporating different ions, such as silicon (Si) [3], lithium (Li) [4] magnesium (Mg) [5], carbonate (CO 3 ) [6], zinc (Zn) [7], silver (Ag) [8], fluoride, (F) [9], chloride (Cl) [10], potassium (K) [11], copper (Cu) [12], sulphate (SO 4 ) [13], tantalum (Ta) [14], cerium [15] or strontium (Sr) [16] into the HA lattice, in order to mirror the complex chemistry of human bone. Many reports of the use of these substituted materials can be found in the literature, both as bone substitute materials and as coatings [17][18][19].…”

Development of plasma electrolytic oxidation for improved Ti6Al4V biomaterial surface properties

“…The abovementioned nano-and micro-surface layers obtained by the EP, MEP, HDEP, and PEO (MAO) treatments are often formed on biomaterials for their improved biocompatibility [19]. In addition, in some of the operations of PEO/MAO, a special effort is taken for the surface layers to be enriched in the chemical elements like silver and/or copper, which are bactericidal [20][21][22][23][24].…”

Surface Treatments to Modulate Bioadhesion: A Critical Review

“…Ion beam technology has also been employed to produce various topographies and surface chemistries, mainly through the use of ion beam sputtering [173][174][175] but ion beam etching has also been effectively employed [176]. Trujillo et al [173] have shown that ion beam sputtered silver-doped hydroxyapatite on titanium can have the advantage of hindering Staphylococcus epidermis and Pseudomonas aeruginosa growth. Having said this, they also correctly state that these surfaces are not fully stable and as a result require further investigation.…”