Antibacterial effects of natural compounds on biofilm formation of Streptococcus mutans

Abstract

Streptococcus mutans is the main cariogenic pathogen in the oral cavity, considered to contribute toward oral diseases. S. mutans is predominantly entrapped in plaque biofilms. Objectives In this study, we surveyed the antibacterial activity of natural compounds in terms of the biofilm production of S. mutans. Material and Methods We extracted the studies related to natural compounds affected on S. mutans biofilm from different databases. Results Disruption of S. mutans viability in biofilms by a potent new pharmacological factor could inhibit and remove cavities. Various antibacterial agents are needed to destroy biofilms that remove both pathogens and commensal bacteria, and also exert inhibitory effects on many bacterial species. Conclusions An effective therapeutic agent for dental caries has to be capable of removing pathogens and their biofilms. Specific virulence attributes of S. mutans exist; hence, natural compounds that have excellent properties to combat such pathogens need to be selected.

Mechanochemical Properties of Mucoadhesive Tablets Based on PVP/HPβCD Electrospun Nanofibers as Local Delivery of Polygoni cuspidati Extract for Treating Oral Infections

“…P. cuspidati extracts exhibited activity against all studied bacteria. Resveratrol, one of the main ingredients, has been shown to reduce oral S. mutans biofilm formation, leading to a reduction in dental caries [19,20], which may also explain the activity of the entire extract. Microbial growth has been observed for polydatin because, as a glycoside, it is a carbon source for microorganisms.…”

Alterations and correlations in dental plaque microbial communities and metabolome characteristics in patients with caries, periodontitis, and comorbid diseases

“…Sphingolipid metabolism was altered in patients with cariescomplemented periodontitis. Sphingolipids can destroy biofilms containing Streptococcus mutans [26], the main microbes that cause dental caries [27]. Photosynthesis is an important metabolic pathway in Cyanobacteria, and its metabolites include potent toxins [28].…”

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects

“…Resveratrol, also known as trans-3,4,5-trihydroxystilbene, is a naturally derived polyphenolic compound and phytoalexin. It is synthesized in response to various stressors, including plant damage or microbial infections caused by bacteria or fungi (95). Resveratrol is commonly found in a variety of dietary substances, such as grapes, berries (cranberries), red wine, nuts (peanuts) and other foods (96)(97)(98).…”